Serratia marcescens HL1 strain for treating Alzheimer's disease and application

A technology of Serratia marcescens and Alzheimer's disease, applied in the field of microorganisms, can solve the problems of difficulty in obtaining pure optically active compounds, high cost, and lack of plant resources, so as to solve the demand for medication and reduce medical expenses , the effect of protecting plant resources

Active Publication Date: 2021-09-03
XIAN MEDICAL UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] The purpose of the present invention is to provide a Serratia marcescens HL1 strain that can be used for the treatment of Alzheimer's disease, to solve the bottleneck of plant resource scarcity in obtaining huperzine A from plant extraction; Difficulty in obtaining purely optically active compounds

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  • Serratia marcescens HL1 strain for treating Alzheimer's disease and application
  • Serratia marcescens HL1 strain for treating Alzheimer's disease and application
  • Serratia marcescens HL1 strain for treating Alzheimer's disease and application

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Embodiment Construction

[0023] The present invention will be described in detail below in conjunction with the accompanying drawings and specific embodiments.

[0024] The present invention is a Serratia marcescens HL1 strain that can be used for treating Alzheimer's disease. Serratia marcescens HL1 strain, the amino sequence of which is shown in SEQ ID NO:1.

[0025] The strain has been preserved in China Ordinary Microorganism Culture Collection Center, a preservation unit designated by the State Intellectual Property Office.

[0026] Biological material deposit information:

[0027] Name: Serratia marcescens (Serratia marcescens) HL1 strain

[0028] Deposit number: CGMCC No.21397

[0029] Deposit unit: General Microbiology Center of China Committee for Microorganism Culture Collection (CGMCC)

[0030] Preservation time: December 18, 2020

[0031] Address: No. 3, Yard No. 1, Beichen West Road, Chaoyang District, Beijing

[0032] (1) the isolation method of the present invention highly express...

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Abstract

The invention discloses a serratia marcescens HL1 strain for treating Alzheimer's disease and an application. The strain is separated from wild huperzia serrata endophytic bacteria and belongs to the serratia marcescens HL1 strain, and the amino sequence of the serratia marcescens HL1 strain is shown as SEQ ID NO: 1. The serratia marcescens HL1 strain is used as a biological strain for treating the Alzheimer's disease, the excellent huperzine A-producing high-efficiency expression gene of the serratia marcescens HL1 strain is transferred into other types of strains, more excellent characters are obtained through gene modification, and in addition, the strain can be further optimized through mutation breeding. Research of the serratia marcescens HL1 strain has great significance in biosynthesis industrial production of huperzine A, protection of plant resources, solving of clinical first-line medication requirements and reduction of medical cost for treating Alzheimer's disease.

Description

technical field [0001] The invention belongs to the technical field of microorganisms, and in particular relates to a Serratia marcescens strain which can be used for treating Alzheimer's disease, and also relates to the application of the bacterial strain. Background technique [0002] Currently, the class of acetylcholinesterase inhibitors dominates the Alzheimer's disease drug market. Huperzine A is a new type of lycopodium monomeric alkaloid isolated from the folk herbal medicine Huperzia serrata. It is a potent and reversible cholinesterase inhibitor with multi-target effects. The inhibitory effect is 3 times that of physostigmine and 30 times that of galantamine, and the peripheral adverse reactions are low. It is one of the clinically preferred drugs for the treatment of Alzheimer's disease. [0003] The development of drugs derived from natural plants has a long history and is full of vitality. Plant extraction to obtain huperzine A is the easiest way, but plant ext...

Claims

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Application Information

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IPC IPC(8): C12N1/20C12P17/12A61P25/28C12R1/43
CPCC12P17/12A61P25/28Y02A50/30
Inventor 韩文霞韩忠文李伟泽王琳张寒孙静李小峰贾敏
Owner XIAN MEDICAL UNIV
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