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Research on inhibition effect of gas neuroprotective agent on NLRP3 inflammasome and application of gas neuroprotective agent

A neuroprotective agent and inflammasome technology, applied in the field of biomedicine, can solve the problems of drug dependence, discount of MCC950 treatment effect, inconvenient treatment, etc.

Inactive Publication Date: 2021-09-07
NANTONG UNIVERSITY
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Problems solved by technology

[0006] At present, the therapeutic effect of MCC950 depends on recanalization of blood vessels. If there are patients who cannot undergo recanalization of blood vessels in clinical practice, the therapeutic effect of MCC950 will be greatly reduced.
Furthermore, the administration method of MCC950 depends on injection administration, which is inconvenient to give treatment

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  • Research on inhibition effect of gas neuroprotective agent on NLRP3 inflammasome and application of gas neuroprotective agent
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  • Research on inhibition effect of gas neuroprotective agent on NLRP3 inflammasome and application of gas neuroprotective agent

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Embodiment Construction

[0052] In order to make the technical problems, technical solutions and advantages to be solved by the present invention clearer, the following will describe in detail with reference to the drawings and specific embodiments.

[0053] The invention provides a gas neuroprotective agent as an inhibitor of NLRP3 inflammasome, which is used for the preparation of medicine for preventing or treating acute ischemic stroke, and provides a guiding scheme for its treatment. The gaseous neuroprotectant is an argon-oxygen gas mixture targeting NLRP3 inflammasomes. Through the establishment of animal and cell models of ischemic stroke, the application of behavioral, molecular biology, protein level detection and other means to understand the protective effect of argon intervention on cerebral ischemia-reperfusion injury, and to explore the role of NLRP3 inflammasome in argon Gas regulates the activity of microglial cells to play a participatory role in neuroprotection and the specific mole...

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Abstract

The invention provides a gas neuroprotective agent which is argon-oxygen mixed gas. A research method of the inhibition effect of the gas neuroprotective agent on NLRP3 inflammasome comprises the following steps of: S1, establishing an animal and cell model of cerebral arterial thrombosis; S2, observing the influence of argon on the inflammatory activation of lipopolysaccharide-stimulated primary microglial cells and a molecular mechanism on the cell model; and S3, discussing the effect of regulation of argon on NLRP3 inflammasome in microglial cell activation in neuroprotection of cerebral ischemia-reperfusion injury. The NLRP3 inflammasome inhibitor provided by the invention is a gas inhibitor, is improved aiming at the defects of the existing inhibitor, is easy in administration mode, does not depend on vascular recanalization, and can prolong the treatment time window in the acute attack period; most importantly, as a gas neuroprotective agent, the argon-oxygen mixed gas has a better treatment effect.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and in particular relates to the research and application of a gas neuroprotective agent inhibiting NLRP3 inflammasomes. Background technique [0002] The inflammasome is an important element of innate immunity. It acts as a large multiprotein complex that can recognize host-derived danger signal molecules (DAMPs) and pathogen-encoded pathogen-associated molecular patterns (PAMPs), and can trigger and activate inflammatory astronine Caspase-1 mediates the extracellular release of interleukin 1β (IL-1β) and leukocyte 18 (IL-18), which plays a role in promoting the development of inflammation. At present, inflammasomes are divided into NLRP1, NLRP2, NLRP3, HIN-200 family cytoplasmic DNA sensor melanoma deficiency factor 2 (AIM2) and NLRC4 according to different receptor proteins. The most characteristic of these inflammasomes is NLRP3 inflammasome. [0003] The NLRP3 inflammasome is currently...

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Application Information

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IPC IPC(8): A61K33/00A61P25/00A61P9/10A61P25/28
CPCA61K33/00A61P25/00A61P9/10A61P25/28A61K2300/00
Inventor 李霞薛珂张云峰祁勉折佟平何娟
Owner NANTONG UNIVERSITY
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