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Composition containing pinoresinol diglucoside and genipin and application thereof

A technology of pinoresinol diglucoside and composition, which is applied in the field of traditional Chinese medicine preparation, can solve the problems of increased types and contents, increased drug costs, and kidney side effects, and achieve the goals of promoting extraction, increasing medicinal value, and increasing the content of active ingredients Effect

Active Publication Date: 2021-09-07
JIANGXI POZIN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Although the above prior art can play a certain therapeutic effect on hypertensive nephropathy, due to the large number of raw materials of traditional Chinese medicine, the types and contents of other harmful substances will also increase, and long-term use will have certain side effects for the kidneys. There are many types, and the cost of drugs is bound to increase

Method used

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  • Composition containing pinoresinol diglucoside and genipin and application thereof
  • Composition containing pinoresinol diglucoside and genipin and application thereof

Examples

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Effect test

Embodiment 1

[0043] A composition containing pinoresinol diglucoside and genipin, in parts by weight, the composition comprises the following components: 13 parts of pinoresinol diglucoside, 12 parts of genipin, 5 parts of nicotinamide, 3 parts of quercetin, 5 parts of Achyranthes knuckle extract, 4 parts of tartronic acid, 2 parts of citric acid.

[0044] Wherein, the preparation method of the Achyranthes Radix extract comprises the following steps:

[0045] (1) Take Achyranthes bidentata and add distilled water to extract at 70°C for 50 minutes, boil and extract for 1.5 hours, filter to obtain water extract and residue;

[0046] (2) Take the residue and extract it for 1.5h in 40% ethanol aqueous solution by mass fraction first, then make the primary extract and filter residue, take the filter residue and extract it in 70% ethanol aqueous solution for 1.5h, and obtain the secondary Extracting solution, after extraction, merging primary extracting solution and secondary extracting solutio...

Embodiment 2

[0051] A composition containing pinoresinol diglucoside and genipin, in parts by weight, the composition comprises the following components: 10 parts of pinoresinol diglucoside, 10 parts of genipin, 1 part of nicotinamide, 1 part quercetin, 1 part achyranthes extract, 1 part tartronic acid, 1 part citric acid.

[0052]Wherein, the preparation method of the Achyranthes Radix extract comprises the following steps:

[0053] (1) Take Achyranthes bidentata and add distilled water to extract at 60°C for 30 minutes, boil and extract for 1 hour, filter to obtain water extract and residue;

[0054] (2) Take the residue and extract it for 2 hours in the ethanol aqueous solution of 30% mass fraction, then make the primary extract and filter residue, take the filter residue and extract it in the ethanol aqueous solution of 60% mass fraction for 2 hours, and make the secondary extract After the extraction, the primary extract and the secondary extract are combined to obtain an alcohol ext...

Embodiment 3

[0059] A composition containing pinoresinol diglucoside and genipin, in parts by weight, the composition comprises the following components: 30 parts of pinoresinol diglucoside, 20 parts of genipin, 10 parts of nicotinamide, 5 parts of quercetin, 10 parts of achyranthes extract, 8 parts of tartronic acid, and 5 parts of citric acid.

[0060] Wherein, the preparation method of the Achyranthes Radix extract comprises the following steps:

[0061] (1) Take Achyranthes bidentata and add distilled water to extract at 80°C for 60 minutes, boil and extract for 2 hours, filter to obtain water extract and residue;

[0062] (2) Take the residue and extract it for 1 hour in 45% ethanol water solution by mass fraction, then make a primary extraction solution and filter residue, take the filter residue and extract it in 75% mass fraction ethanol solution solution for 1 hour to make a secondary extract solution After the extraction, the primary extract and the secondary extract are combine...

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Abstract

The invention belongs to the technical field of traditional Chinese medicine preparation, and particularly relates to a composition containing pinoresinol diglucoside and genipin and application thereof. The composition containing pinoresinol diglucoside and genipin is prepared from the following components: pinoresinol diglucoside, genipin, nicotinamide, quercetin, a radix achyranthis bidentatae extract, tartronic acid and citric acid. The composition is simple in preparation method, can be used for treating hypertensive nephropathy, has a good curative effect, and can reduce side effects and reduce cost.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine preparation, and in particular relates to a composition containing pinoresinol diglucoside and genipin and an application thereof. Background technique [0002] Hypertensive nephropathy is the structural and functional damage of the kidneys caused by essential hypertension, which can be divided into benign hypertensive nephrosclerosis and malignant hypertensive nephrosclerosis. The former is caused by benign hypertension (≥140 / 90 mmHg) acting on the kidneys for a long time, while the latter refers to the development of malignant hypertension (diastolic blood pressure>130 mmHg) on ​​the basis of essential hypertension. Kidney damage. If hypertension and kidney damage exist at the same time, they will cause each other and aggravate each other. [0003] There are many methods for treating hypertensive nephropathy in the prior art, such as Chinese patent application CN1047845...

Claims

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Application Information

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IPC IPC(8): A61K36/21A61K31/7048A61K31/352A61P9/12A61P13/12A61K31/455A61K31/194
CPCA61K31/7048A61K31/352A61K31/455A61K36/21A61K31/194A61P9/12A61P13/12A61K2236/331A61K2236/333A61K2236/39A61K2236/55A61K2300/00
Inventor 肖军平陈梁李小锋刘厚权张梅红胡吉忠夏淑英毛金娣林飞英
Owner JIANGXI POZIN PHARMA
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