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Application of phosphatidylcholine in preparation of medicine for treating ulcerative colitis

A technology of ulcerative colitis and phosphatidylcholine, which is applied in the field of medicine, can solve the problems of unclear etiology of inflammatory bowel disease and difficulties in disease diagnosis and treatment, and achieve good therapeutic activity, relieve colon shortening, and relieve inflammatory infiltration

Active Publication Date: 2021-09-10
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Moreover, the etiology of inflammatory bowel disease is still unclear, which brings difficulties to the diagnosis and treatment of the disease

Method used

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  • Application of phosphatidylcholine in preparation of medicine for treating ulcerative colitis
  • Application of phosphatidylcholine in preparation of medicine for treating ulcerative colitis
  • Application of phosphatidylcholine in preparation of medicine for treating ulcerative colitis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Example 1: Application research of PC (18:1 / 16:0) in treating ulcerative colitis induced by sodium dextran sulfate

[0016] Step 1: Experimental grouping (8-week-old C57 male mice, n=6)

[0017] i) Control group: After the modeling started, normal saline (0.2 mL / 20 g) was injected intraperitoneally every day, and they were allowed to eat and drink freely.

[0018] ii) Modeling group: free to eat and drink 2.5% dextran sodium sulfate aqueous solution. After the modeling started, an equal volume of normal saline (0.2 mL / 20 g) was injected intraperitoneally every day.

[0019] iii) Treatment group: free to eat and drink 2.5% dextran sodium sulfate aqueous solution. After molding, intraperitoneally inject 2mg / kg PC (18:1 / 16:0) suspension every day.

[0020] iii) Positive drug group: free to eat and drink 2.5% dextran sodium sulfate aqueous solution. After molding, 100 mg / kg sulfasalazine (SASP) suspension was administered intragastrically every day.

[0021] Step 2: Es...

Embodiment 2

[0027] Example 2: Pharmacological study of PC (18:1 / 16:0) in treating ulcerative colitis induced by sodium dextran sulfate

[0028] Step 1: Experimental grouping (8-week-old C57 male mice, n=6)

[0029] i) Control group: After the modeling started, normal saline (0.2 mL / 20 g) was injected intraperitoneally every day, and they were allowed to eat and drink freely.

[0030] ii) Modeling group: free to eat and drink 2.5% dextran sodium sulfate aqueous solution. After the modeling started, normal saline (0.2 mL / 20 g) was injected intraperitoneally every day.

[0031] iii) Treatment group: free to eat and drink 2.5% dextran sodium sulfate aqueous solution. After molding, intraperitoneally inject 2mg / kg PC (18:1 / 16:0) suspension every day.

[0032] iii) Positive drug group: free to eat and drink 2.5% dextran sodium sulfate aqueous solution. After molding, 100 mg / kg sulfasalazine (SASP) suspension was administered intragastrically every day.

[0033] Step 2: Establish a model of...

Embodiment 3

[0047] Example 3: Study on the mechanism of PC (18:1 / 16:0) in treating ulcerative colitis induced by sodium dextran sulfate

[0048] Step 1: Experimental grouping (8-week-old C57 male mice, n=6)

[0049] i) Control group: After the modeling started, normal saline (0.2 mL / 20 g) was injected intraperitoneally every day, and they were allowed to eat and drink freely.

[0050] ii) Modeling group: free to eat and drink 2.5% dextran sodium sulfate aqueous solution. After the modeling started, an equal volume of normal saline (0.2 mL / 20 g) was injected intraperitoneally every day.

[0051] iii) Treatment group: free to eat and drink 2.5% dextran sodium sulfate aqueous solution. After molding, intraperitoneally inject 2mg / kg PC (18:1 / 16:0) suspension every day.

[0052] iii) Positive drug group: free to eat and drink 2.5% dextran sodium sulfate aqueous solution. After molding, 100 mg / kg sulfasalazine (SASP) suspension was administered intragastrically every day.

[0053] Step 2: Es...

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Abstract

The invention discloses application of phosphatidylcholine in preparation of a medicine for treating ulcerative colitis, and belongs to the field of pharmacy. By providing a mouse colitis model orally taking 2.5% dextran sodium sulfate, the research finds that the PC 18: 1 / 16: 0 has good treatment activity; and experiments prove that the PC 18: 1 / 16: 0 can effectively relieve weight loss and colon shortening caused by ulcerative colitis, maintain colon epithelial cell and goblet cell morphology and relieve inflammatory infiltration. In addition, the PC 18: 1 / 16: 0 can significantly reduce the expression of inflammatory factors, thereby relieving the lesion of ulcerative colitis. The potential pharmaceutical application prospect is realized.

Description

technical field [0001] The invention belongs to the technical field of medicine, in particular to the application of phosphatidylcholine in the preparation of medicine for treating ulcerative colitis. Background technique [0002] Ulcerative colitis (Ulcerative Colitis, UC) is a chronic inflammatory disease, and its lesions mostly start in the rectum, usually involving part or even the entire colon, and some patients with proctitis and sigmoiditis may also have inflammation in the cecum. Bloody diarrhea is the most typical symptom of the disease, the course of the disease is long and indeterminate, and often recurs. Moreover, the etiology of inflammatory bowel disease is still unclear, which brings difficulties to the diagnosis and treatment of the disease. Phosphatidylcholine (Phosphatidylcholine, PC) is a kind of phospholipid, which is an important part of cell membrane and organelle membrane. Phosphatidylcholine consists of a choline-containing hydrophilic head and two ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/685A61K9/10A61P1/00A61P1/04
CPCA61K31/685A61K9/10A61K9/0019A61P1/00A61P1/04
Inventor 梁艳王广基李昌键
Owner CHINA PHARM UNIV
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