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Xerophthalmia treatment preparation and preparation method thereof

A dry eye disease and preparation technology, applied in the field of dry eye treatment preparations and their preparation, can solve the problems of poor treatment effect of dry eye disease, inability to completely supplement ocular surface components of patients with dry eye disease, and the like

Pending Publication Date: 2021-09-10
薛安全 +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] The technical problem to be solved by the present invention is that the existing artificial tears cannot fully supplement the ingredients lacking in the ocular surface of patients with dry eye, resulting in poor therapeutic effect of dry eye

Method used

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  • Xerophthalmia treatment preparation and preparation method thereof
  • Xerophthalmia treatment preparation and preparation method thereof
  • Xerophthalmia treatment preparation and preparation method thereof

Examples

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preparation example Construction

[0037] A preparation method for dry eye treatment preparation, comprising the following steps:

[0038] Weigh the mucin and add water for injection to stir and dissolve, filter and sterilize through a 0.22um microporous membrane to obtain a mucin solution;

[0039] Mix sodium hyaluronate, glycerin and oil, shear and emulsify in emulsifier dissolved in water, and then homogenize in a high-pressure homogenizer to obtain an emulsified solution;

[0040] Fusing the emulsified solution with the preparation matrix, adjusting the pH of the solution to between 6.5 and 7.8, and performing high-pressure sterilization to obtain a sterile intermediate product;

[0041] The aseptic intermediate product is mixed with the mucin solution, and packaged under aseptic conditions to obtain the finished preparation.

[0042] In the above scheme, preferably, the shear rate is 500-1000 rpm, and the emulsification time is 10 min.

[0043] In the above solution, preferably, the primary valve pressur...

specific Embodiment 1

[0051]

[0052] Preparation method: a. Weigh the mucin and add 100ml of water for injection, stir and dissolve at a temperature of 30-50°C, filter and sterilize through a 0.22um microporous membrane to obtain a mucin solution;

[0053] b. Mix glycerol, sodium hyaluronate and soybean lecithin, add the aqueous solution of poloxamer 188 emulsifier, and use a high-pressure homogenizer to shear and emulsify, wherein the shear rate is 500-1000rpm, and the emulsification time is 10min ;Adjust the primary valve pressure of the high-pressure homogenizer to 400-800bar, and homogenize for 5-10 minutes to obtain a uniformly dispersed emulsified solution;

[0054] c. After the high-pressure homogenization, adjust the pH of the emulsified solution to 6.5-7.8, and place it at 121°C for 20 minutes for autoclaving;

[0055] d. Evenly disperse the mucin solution into the above solution, dilute to 1000ml with water for injection, and seal under aseptic conditions to obtain a single-dose eye d...

specific Embodiment 2

[0057]

[0058] Preparation method: a. Weigh the mucin and add 100ml of water for injection, stir and dissolve at a temperature of 30-50°C, filter and sterilize through a 0.22um microporous membrane to obtain a mucin solution;

[0059] b. Mix glycerol, sodium hyaluronate and caprylic / capric triglyceride, add the aqueous solution of poloxamer 188 emulsifier, and shear and emulsify for 10 minutes at a shear rate of 500-1000 rpm; The pressure of the primary valve of the quality machine is 400-800bar, homogenize for 5-10 minutes, and obtain a uniformly dispersed emulsified solution;

[0060] c. After the high-pressure homogenization, adjust the pH of the emulsified solution to 6.5-7.8, and place it at 121°C for 20 minutes for autoclaving;

[0061] d. Evenly disperse the mucin solution into the above solution, dilute to 1000ml with water for injection, and seal under aseptic conditions to obtain a single-dose eye drop.

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Abstract

The invention discloses a xerophthalmia treatment preparation and a preparation method thereof. Dosage forms of the preparation comprise eye drops, oculentum, eye gel and the like, and the preparation is prepared from the following components in percentage by mass: 0.0-1.0% of sodium hyaluronate, 1.0-10.0% of mucoprotein, 1.0-2.0% of glycerol, 1.0-10.0% of grease, 0-1.8% of an emulsifier and 42.0-95.0% of a matrix. The xerophthalmia treatment preparation contains water, mucoprotein, lipid and other necessary components for forming a physiological tear film, can sufficiently supply xerophthalmia tear film lacking components, enables the tear film of a patient to recover a normal physiological structure and maintain stability, quickly relieves symptoms such as dryness and stabbing pain, avoids and relieves ocular surface damage, and has the advantages of being small in administration frequency, free of stimulation and good in comfort degree.

Description

technical field [0001] The invention relates to the technical field of dry eye treatment, in particular to a dry eye treatment preparation and a preparation method thereof. Background technique [0002] Dry eye syndrome refers to a tear secretion disorder eye disease caused by a variety of factors, with dry eyes as the main symptom, often accompanied by itching, foreign body sensation, burning sensation in both eyes, or photophobia, blurred vision, and vision fluctuations. . [0003] Dry eye is very common in ophthalmology clinic. In recent years, with the development of the times, due to the proliferation of electronic products, the increase in the use of contact lenses, the increase in unhealthy lifestyles such as staying up late and excessive use of mobile phones and computers, social and environmental factors such as climate warming and low air humidity, dry eye syndrome The incidence of dry eye is increasing year by year, and individual factors such as long-term use o...

Claims

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Application Information

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IPC IPC(8): A61K38/17A61K45/06A61K47/10A61K47/44A61P27/02A61P27/04A61P27/06A61K9/06A61K9/08A61K31/047A61K31/23A61K31/685A61K31/728
CPCA61K38/17A61K31/728A61K31/685A61K31/23A61K31/047A61K45/06A61K9/06A61K47/44A61K47/10A61K9/08A61K9/0048A61P27/04A61P27/06A61P27/02A61K2300/00
Inventor 郁引飞王晓玲薛安全
Owner 薛安全
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