24 results about "DISORDER EYE" patented technology

The present invention belongs to the technical field of polymer compounds, and specifically relates to the use of amphiphilic cationic modified mPEG-PCL nanoparticles in the preparation of drugs for treating retinal diseases. The technical problem to be solved by the present invention is the lack of nanomedicines for the treatment of retinal diseases. The technical solution of the present invention is the use of amphiphilic cationic modified mPEG-PCL nanoparticles in the preparation of drugs for treating eye diseases. The nanoparticles of the present invention have low cytotoxicity; can effectively inhibit the development of choroidal neovascularization; and can also be used as carriers for other eye disease-related drugs, enabling combined drug use and the treatment of various eye diseases.

The invention discloses a retina image processing method, system and device for ophthalmic diseases, and belongs to the technical field of image analysis, and the method comprises the steps: carrying out the quality inspection and preprocessing of an uploaded retina image, and obtaining a to-be-recognized retina image; lesion positioning and refraction problem recognition are carried out on the to-be-recognized retina image, and a lesion thermodynamic diagram and an eye disease recognition result are output; based on a preset ophthalmic disease database, performing confidence calculation on the eye disease recognition result to obtain a corresponding treatment suggestion; and according to the focus thermodynamic diagram, the eye disease identification result and the treatment suggestion, generating a diagnosis and treatment sheet of the retina image. Therefore, by implementing the method and the device, the problems that various retinal diseases and refraction problems cannot be quickly and accurately identified from the provided retinal image and effective clinical diagnosis opinions cannot be provided for the identified ophthalmic diseases in the prior art can be solved.

The present disclosure provides an ophthalmic formulation comprising: one or more pharmaceutically acceptable excipients; a pharmaceutically active compound capable of reducing the amount or deleterious effects of autoantibodies on the ocular surface, such as IgG; in particular, the present disclosure provides an ophthalmic formulation wherein the pharmaceutically active compound is capable of treating a clinical condition selected from the group consisting of inflammatory, infectious and immunological ocular surface or intraocular diseases that can cause symptoms of ocular discomfort, keratitis, dry eye disease, formation of symblepharon, shortening of the anterior chamber depth, lid margin / conjunctival keratinization, subconjunctival fibrosis, retinal gliosis and glaucoma.

Provided herein are methods of treating eye disorders by administering an anti-VEGF antibody and / or conjugate to a subject having an eye disorder. The anti-VEGF antibody of the present disclosure may be an anti-VEGF antibody conjugate that includes a polymeric moiety that extends the half-life / effectiveness / properties of the antibody when administered to a subject. A method of the present disclosure includes administering one or more doses of an anti-VEGF antibody conjugate to a subject (e.g., human or other mammalian patient) in need of treating an eye disorder, where the anti-VEGF antibody conjugate may be administered less frequently than a standard anti-VEGF therapy to treat the eye disorder.

The invention relates to an eye disease and nerve disease integrated diagnosis and treatment system based on visual signal perception, and belongs to the technical field of visual function detection and diagnosis and treatment assistance. The method comprises the following steps: dynamically generating a black and white checkerboard stimulation signal through a visual stimulation generation unit, and triggering an eye and a nervous system to generate an original evoked potential signal; the signal acquisition and transmission unit acquires and sends the signal through an electrode plate and a wireless transmission module; the signal processing and judging unit is used for carrying out superposition processing on the signals, extracting effective waveforms and automatically executing spatial frequency threshold search to determine a minimum checkerboard; and the diagnosis and treatment scheme output unit generates a stimulation program based on the minimum checkerboard and dynamically generates a personalized diagnosis and treatment report. The full-process automation from stimulation generation, signal processing to scheme output is realized, the accuracy of threshold judgment and the personalization of the stimulation scheme are improved, and efficient and reliable technical support is provided for auxiliary diagnosis and curative effect evaluation of eye diseases and nerve diseases.

The present disclosure provides a composition and method for preventing or treating eye diseases. Specifically, a method for preparing mesenchymal stem cell conditioned medium is provided, which includes isolating mesenchymal stem cells from an individual, maintaining the mesenchymal stem cells in a mesenchymal stem cell maintenance medium, collecting the mesenchymal stem cells at passages 2 to 5, culturing the mesenchymal stem cells for several hours in a medium supplemented with fetal bovine serum and a mesenchymal stem cell medium adjuvant to obtain the mesenchymal stem cell conditioned medium, collecting the conditioned medium, and filtering it after centrifugation. The present disclosure also provides a method for preventing or treating an ocular epithelial tissue disorder such as dry eye disease, which includes administering the conditioned medium to the eye of an individual. The present disclosure further provides a pharmaceutical composition comprising the conditioned medium.

The invention relates to the technical field of intraocular lenses, in particular to a multi-focus intraocular lens dynamic tuning system and method for complex eye diseases. The invention relates to a multi-focus intraocular lens dynamic tuning system which integrates multiple functions of eyeball parameter receiving, tuning instruction generation, micro electrode array adjustment, driving loop control, electric control zoom lens dynamic focusing, wireless energy supply and monitoring, eyeball movement monitoring, safety control, data processing and display and the like. The system monitors eyeball movement in real time and dynamically adjusts the shape and the thickness of the crystal, so that accurate focusing is realized, and the visual quality and the adjusting performance are remarkably improved. Meanwhile, energy efficiency is improved through wireless energy supply, and safe operation is ensured through intelligent monitoring. The system breaks through the limitation of the prior art, creates a new intelligent intraocular lens normal form, provides an efficient, safe and intelligent solution for complex eye disease treatment, and has wide application prospects and great clinical value.

The invention belongs to the technical field of visual function inspection devices, and relates to an adjusting amplitude inspection device based on a turnover mirror and a using method thereof.The adjusting amplitude inspection device comprises a fixing support, the turnover mirror and a sighting mark structure, the turnover mirror and the sighting mark structure are arranged at the two ends of the fixing support, and the sighting mark structure is slidably arranged on the fixing support; the sighting mark structure is arranged on the fixing support to be close to or away from the overturning mirror, and a length scale arranged in the sliding direction of the sighting mark structure is arranged on the fixing support. Accuracy and reliability of adjustment amplitude examination are remarkably improved, the method is suitable for groups such as children and patients with special refraction, the clinical operation process is simplified, the application range is expanded, eye diseases such as asthenopia and myopia progress are effectively diagnosed through standardized stimulation and dynamic adjustment, and progress of eye vision light practice is promoted.

The invention relates to an eye-protecting health-care traditional Chinese medicine composition, which is used for relieving eye fatigue, improving vision and preventing or assisting in treating retinopathy and xerophthalmia, and has the comprehensive effects of clearing liver and improving vision, nourishing blood and liver, promoting blood circulation to remove meridian obstruction, nourishing yin and moistening dryness. All the components have a synergistic effect in efficacy, and the effects of eye protection and health care are achieved by regulating the liver function, enhancing eye blood circulation, improving cell metabolism and enhancing the immune function. According to the traditional Chinese medicine composition disclosed by the invention, various medicinal materials have a good synergistic effect, and the multiple effects of clearing liver and improving vision, nourishing blood and liver, promoting blood circulation to remove meridian obstruction, nourishing yin and moistening dryness are comprehensively exerted by regulating liver and kidney functions, improving eye microcirculation, enhancing cell metabolism capability and improving immune level; therefore, eye fatigue is effectively relieved, eyesight is improved, common eye diseases such as retinopathy and xerophthalmia are prevented or treated in an auxiliary manner, and the eye cream is suitable for sub-health people and daily health care requirements.

The invention relates to the field of medicine, in particular to universal antiviral eyedrops and a preparation method thereof. The antiviral eyedrop comprises 5-19% by mass of sodium chloride and 95-81% by mass of pure water, and is a special advanced physiological sodium chloride water-soluble solution prepared by a specific method. The mechanism for preparing the antiviral eyedrops from sodium chloride is as follows: firstly, the content of sodium chloride in a sodium chloride water-soluble liquid is determined to be greater than or equal to 5% for the first time, and the eyedrops have a universal specific medicinal function of resisting eye disease viruses; and secondly, the tolerable safety limit value of the eyes of people to the sodium chloride content of the sodium chloride water-soluble liquid can reach 19% threshold value for the first time. According to the invention, the sodium chloride content ratio threshold value of the 5-19% sodium chloride water-soluble liquid with unified effectiveness and safety is set as a basic technical formula and standard for preparing the novel antiviral eye drops from sodium chloride. Meanwhile, the antiviral eyedrops are designed to be light and thick so as to be suitable for patients in primary clinical treatment.

Provided herein is a method for treating, preventing, or ameliorating one or more symptoms of an inflammatory eye disease, disorder, or condition with a JAK inhibitor, for example, a tricyclic JAK inhibitor of Formula (I). Also provided herein is a stable ophthalmic composition comprising a JAK inhibitor, for example, a tricyclic JAK inhibitor of Formula (I); and a buffering agent, a mucoadhesive agent, a preservative, a solubilizer, a tonicity agent, or water, or a mixture thereof.

The utility model discloses a pair of lesion visual simulation glasses, which comprises a main frame connected with glasses legs or a head-mounted structure; the support is connected with the main frame, and an inserting groove is formed in the support; the vision simulation module is detachably inserted into the slot, and a lesion simulation layer is arranged on the vision simulation module. According to the lesion visual simulation glasses, the lesion simulation layer is arranged on the vision simulation module and used for simulating the visual effect of eye lesion when a normal person wears the glasses, and therefore products suitable for the old can be developed conveniently. The bracket is provided with the slot, and the vision simulation module is detachably inserted into the slot, so that the vision simulation module provided with different lesion simulation layers can be replaced, the vision simulation module is used for simulating a visual effect without eye diseases, and the simulation cost can be reduced.

The utility model discloses a glasses frame capable of adjusting interpupillary distance, which consists of a left sheet frame, a right sheet frame, an upper eyebrow, a left glasses leg and a right glasses leg, the left glasses leg and the right glasses leg are respectively arranged on the left side and the right side of the upper eyebrow, a buckle is arranged on the upper eyebrow corresponding to a nose bridge, and a support rod with a scale is fixed on the buckle. And the left and right lens frames for mounting the lenses are respectively mounted on the left and right sides of the supporting rod in a relative sliding manner. The utility model also discloses a pair of glasses using the glasses frame. The pair of eyeglasses has the advantages of few components, simpler structure and easier assembly, can complete the interpupillary distance adjustment by directly pulling the lens frame to slide on the support rod and stopping pulling when reaching a proper interpupillary distance, is very convenient, rapid and accurate in adjustment operation, is suitable for network sales and purchase, is also suitable for correcting eye diseases such as strabismus with asymmetric left and right interpupillary distances, and is suitable for popularization and application. The auxiliary treatment effect is realized.

This invention relates to a nanoparticle, its preparation method and application, and a drug comprising the nanoparticle for treating eye diseases and its preparation method. The nanoparticle comprises ribonucleic acid (RNA) and thiols, wherein the RNA comprises double-stranded RNA and RNA aptamers.

The invention discloses an on-site operation and maintenance work safety guidance device based on AI glasses, which comprises a safety helmet main body and an AI single lens, the safety helmet main body comprises a brim, a fixed box with an opening at the bottom is fixedly arranged below the brim, and the middle part of the top of the fixed box is provided with a hidden box protruding upwards. A fixed box and a hidden box located above the fixed box are arranged, a belt transmission mechanism is installed in the fixed box, a conveying belt on the belt transmission mechanism passes through the top in the hidden box and is connected with a door-shaped frame through a hanging mechanism, an AI single lens is arranged in the door-shaped frame, and the conveying belt can drive the door-shaped frame to enter and exit from the hidden box through the hanging mechanism during operation. Meanwhile, the door-shaped frame can be driven to move to the position in front of the left eye or the right eye of an executor, so that the left eye and the right eye can watch the AI single lens in turn according to needs, eye fatigue can be effectively relieved, the risk of eye diseases can be reduced, the hidden box has the function of hiding and protecting the AI single lens, and the AI single lens can be effectively prevented from being polluted, collided and damaged.

A device for treating eye disorders, particularly disorders of the internal tissues of the eye, comprises a mask and a plurality of light-emitting diodes (LEDs) arranged on the inner surface of the mask. The plurality of LEDs includes a matrix of at least one LED arranged in a region of the inner surface of the mask that is adapted to face the user's eyeball area when in use, and is configured to emit electromagnetic radiation adapted to stimulate the cellular function of retinal cells.

The invention provides a vehicle-mounted head-up display control method, system and device. The method comprises the steps that the final visual focusing time and the final focusing stabilization time of a driver are collected in real time; evaluating the final visual focusing time and the final focusing stable time based on a preset visual focusing time range and a preset focusing stable time range to obtain a visual focusing time evaluation result and a focusing stable time evaluation result; obtaining a final evaluation result based on the visual focusing time evaluation result and the focusing stabilization time evaluation result; and adjusting the display parameters of the vehicle-mounted head-up display in real time based on the final evaluation result. According to the method provided by the invention, the technical problems that in the vehicle driving process, part of eye disease patients such as presbyopia patients are difficult to quickly and clearly identify near vehicle-mounted head-up display contents due to slow vision focusing speed and inflexible focus switching, the driving experience is poor, and the driving safety is influenced are effectively solved.

In the present invention azidation is used to render a molecule photoactivable and to influence its binding to its cognate specific binding partner in the eye. Thus, the invention relates to a compound for use in a method of treating a subject with an ocular disease said compound comprising - a conjugated electron system - an active agent moiety, - an azide (N3) moiety comprising an azido group, wherein the π electrons of the azido group extend the conjugated electron system to form an extended conjugated electron system, whereby the active agent moiety can be bound to the binding site of the biological target, and the azide moiety can be photoactivated by the light entering via the optical system of the eye, whereby the engineered molecule becomes linked to the biological target via a covalent bond, whereby the compound modulates the said biological target in the eye to provide an improved treatment for said subject.

The invention belongs to the field of animal model construction, and particularly relates to a construction method and application of an early embryonic development cataract eye disease animal model. The invention finds that acute exposure of N-(1, 3-dimethylbutyl)-N '-phenyl-p-phenylenediamine (6PPD) and polystyrene microspheres (PS) in an embryonic development stage can cause eye dysplasia and visual dysfunction in a zebra fish larva stage, and the zebra fish has typical lens opacification-like cataract pathological characteristics; meanwhile, the phenomena of phototactic behavior inhibition, eye cell death increase and the like occur. The 6PPD / PS treatment interferes with visual perception and phototransduction pathways, significantly affects photoreceptor outer segment, ferroptosis, endocytosis, retinoic acid metabolism and other pathways, and can enhance the activation of ferroptosis regulation genes by enhancing oxidative stress and mitochondrial dependent apoptosis of eye tissues, thereby aggravating the cataract process. The invention finds that cataract can be generated through the 6PPD / PS effect in the development process of freshwater fish vertebrates for the first time, and provides model support for research on pathogenesis and intervention strategies of the freshwater fish vertebrates.

The invention relates to the technical field of eye care liquid, and particularly discloses eye care liquid and a preparation method thereof. The eye health-care liquid is prepared from the following raw materials in parts by weight through biological fermentation: 1-6 parts of chrysanthemum, 1-6 parts of semen cassiae, 1-5 parts of ginseng, 1-6 parts of radix zanthoxyli, 1-5 parts of cinnamon, 1-10 parts of red dates, 1-5 parts of cassia twig, 1-6 parts of safflower, 1-8 parts of white poria, 1-4 parts of radix saposhnikoviae, 1-8 parts of angelica sinensis, 1-5 parts of ligusticum wallichii and 1-6 parts of radix paeoniae alba. The traditional Chinese medicine composition has the beneficial effects that the composition is high in synergism, the compatibility of monarch, minister, assistant and guide is rigorous aiming at the core pathogenesis of eye diseases such as deficiency of liver and kidney, deficiency of qi and blood and blood stasis and wind heat, and multi-target comprehensive conditioning is realized. A fermentation process under specific conditions is adopted, compared with traditional water decoction or alcohol extraction, the active ingredients are richer, the molecular weight is smaller, transdermal absorption is easier, the bioavailability is remarkably improved, and damage of high temperature to heat sensitive ingredients is avoided.

The application discloses a compound for eye disease repair and a preparation method of the compound by aging extraction, which is synthesized by extracting effective components of Senecio scandens Buch, astaxanthin, Artemisia capillaris Thunb, Gardenia, Ceti, Cassia seed, and has good therapeutic effect on eye diseases such as myopia, pseudomyopia, cataract, glaucoma, chloasma and the like. By taking the extract, intraocular pressure, optic nerve and intraocular pressure tube are gradually improved, so that the eye axis refraction is basically recovered, and the purpose of basic cure is achieved. The extract is obtained by supercritical extraction of pure plants and traditional Chinese medicines, and the compound Tianmocai compound of Senecio scandens Buch is obtained by using three reaction kettles to induce aging technology, the compound is safe and has no side effect, and is an innovative modern new Chinese medicine technical product.

The invention discloses an eye disease physiotherapy extraction composition for cataract and muscae volitantes, which is prepared from the following raw materials by weight: 25-35g of feather cockscomb seed, 25-35g of cassia seed, 25-35g of motherwort fruit, 15-25g of szechwan chinaberry fruit, 15-25g of antelope horn, 15-25g of pearl, 15-25g of butterflybush flower, 15-25g of safflower, 10-20g of mountain ginseng and 10-20g of musk. The preparation method of the eye disease physiotherapy extraction composition for cataract and muscae volitantes comprises the following steps: weighing and preparing the raw materials according to the proportion, cleaning and putting into a marmite; and boiling with big fire, turning to medium fire for 1-2 hours, then turning to small fire, decocting for 10-14 hours until the paste is thick and dark red, and cooling to obtain the traditional Chinese medicine composition. The thunder-fire ointment is prepared by decocting and refining 10 traditional Chinese medicinal materials, takes effect after fire moxibustion treatment for 10 seconds, and can be used for effectively treating cataract, muscae volitantes and glaucoma.

The embodiment of the invention relates to nanoparticles, a preparation method and application thereof, a medicine comprising the nanoparticles and used for treating eye diseases and a preparation method of the medicine. The nanoparticles comprise ribonucleic acid and thiol, and the ribonucleic acid comprises double-stranded ribonucleic acid and a ribonucleic acid aptamer.