Anti-protein adsorbing coating modified base material and preparation method thereof
An anti-protein adsorption and substrate technology, applied in coating, metal material coating process, polyether coating, etc., can solve problems such as difficulty in maintaining service life, pollution, and reduced analysis ability
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[0032] During specific implementation, the preparation method of the anti-protein adsorption coating modified substrate of the present invention comprises:
[0033] The first step is to clean and dry the target substrate; use chemical vapor deposition to deposit 3-aminopropyltrimethylaminosilane on the surface of the target substrate as a base layer, and obtain a primary modified substrate.
[0034] Wherein, the material of the target substrate is a polymer material or a metal material. When cleaning, put the target substrate into water or ethanol solution and use ultrasonic cleaning, and use nitrogen to protect the target substrate during drying; the processing temperature of chemical vapor deposition method is 50°C-70°C, and the processing time is 0.5-12h; the target After the substrate is treated by chemical vapor deposition, it is dried overnight at 70°C±5°C to obtain the primary modified substrate.
[0035] In the second step, the oligoperoxide is dissolved in dioxane to...
Embodiment 1
[0046] In this example, samples are prepared according to the above-mentioned preparation method embodied in the present invention.
[0047] (1) The concrete preparation process of oligoperoxide is:
[0048] 4.6g (0.014mol) pyromellitic acid solution was dissolved in 15ml of anhydrous dichloroethane, placed in a three-necked flask, stirred and mixed, and 1.26g (0.014mol) tert-butyl hydroperoxide was added to form a mixture. The above mixture was cooled to 5°C. 1.1 g (0.014 mol) of pyridine was dissolved in 10 ml of anhydrous dichloroethane, and added dropwise to the above mixture at 5°C, and mixed for 1 h. Then 5.6 g (0.014 mol) of PEG-9 was added and a pyridine solution (2.2 g of pyridine + 10 ml of anhydrous dichloroethane) was added dropwise. After stirring for 3 h, the temperature gradually increased to ambient temperature (ie room temperature). The solution was filtered and dried under vacuum at 40°C for 3h to obtain 8.2g of oligoperoxides.
[0049] (2) The concrete p...
Embodiment 2
[0054] This example is a comparative experiment of protein adsorption test.
[0055] Samples to be tested: the oligo-OEGMA-PU sheet prepared in Example 1, a clean PU sheet, and an OEGMA-PU sheet.
[0056] The preparation process of the clean PU sheet is as follows: the PU sheet is ultrasonically cleaned in ethanol solution (99%) for 20 minutes, and then dried under nitrogen protection.
[0057] The preparation process of OEGMA-PU sheet is:
[0058] i) The PU sheet is ultrasonically cleaned in ethanol solution (99%) for 20 min, and dried under nitrogen protection for later use.
[0059] ii) Dissolve OEGMA monomer (19.08ml) in a solution of water and methanol (12ml, 1:4), and stir for at least 45min under nitrogen protection.
[0060] iii) Put the PU sheet obtained in i) into the above solution, and place it at room temperature under the protection of nitrogen for 0.5-12h. The PU sheet was taken out from the solution, rinsed with alcohol and deionized water respectively, and ...
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