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High-purity hemodialysis concentrated solution and preparation process thereof

A technology of hemodialysis and preparation process, which is applied in the field of high-purity hemodialysis concentrate preparation process, hemodialysis concentrate preparation process, and high-purity hemodialysis concentrate, which can solve the problem of low efficiency, affecting blood calcium, and the inability to adjust the pH balance. issues such as getting the right adjustments

Inactive Publication Date: 2021-10-01
JIANGSU NAHAI BIOLOGICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The hemodialysis solution in the prior art cannot be properly adjusted for the pH balance when it is given to the patient, and the existing adjustment solution such as bicarbonate mainly causes relatively large damage to the human body. Moreover, it also affects blood calcium. In addition, the existing storage of hemodialysate is stored in a concentrated manner, and the process used in the concentration process is time-consuming and laborious, and the efficiency is relatively low. Therefore, a high-purity liquid is designed for this purpose. Hemodialysis concentrate and preparation process improve the above problems

Method used

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  • High-purity hemodialysis concentrated solution and preparation process thereof

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Effect test

Embodiment 1

[0029] In the present embodiment, the raw material, the concentration of each component is: calcium chlorate 5g / L, citric acid 30g / L, heparin 5g / L, calcium chloride 10g / L, potassium chloride 10g / L, magnesium chloride 5g / L, sodium chloride 50g / L, glucose 5-10 g / l, iron citrate 450 mg / L, sodium gluconate iron 1500 mg / L and osmotic pressure regulating electrolyte.

[0030] Based on the above raw material concentration, a high-purity hemodialysis concentrate is prepared, including the following steps:

[0031] Step 1: Take the calcium chlorate 10g / L, citric acid 60 g / L, heparin 25 g / L, calcium chloride 20g / L, potassium chloride, 10 g / L, sodium chloride 10g / L, sodium chloride, 100g / L, glucose 10g / L, iron citrate 950mg / l and sodium gluconate 3000mg / L;

[0032] Step 2: Put the individual components of the quantity into the purified box and placed in the purified box;

[0033] Step 3: Perform high temperature continuous heating 2-4H temperature main...

Embodiment 2

[0040] In the present embodiment, the raw material is taken: the concentration of each component is: calcium chlorate 10g / L, citric acid 60 g / L, heparin 25 g / L, calcium chloride 20g / L, potassium chloride 20g / L, magnesium chloride 10g / L, sodium chloride 100g / L, glucose 10g / L, citrate 950 mg / L, sodium gluconate 3000 mg / L and osmotic pressure regulating electrolyte.

[0041] Based on the above raw materials, the production step of hemodialysis concentrate is the same as that of the examples, and will not be explained herein.

Embodiment 3

[0043] In the present embodiment, the raw material: the concentration of each component is: calcium chlorate 7.5 g / L, citric acid 45 g / L, heparin 15g / L, calcium chloride 15g / L, magnesium chloride, magnesium chloride, magnesium chloride, magnesium chloride, magnesium chloride 7.5 g / L, sodium chloride 75 g / L, glucose 7.5 g / L, citrate 700 mg / L, gluconate 2250 mg / L and osmotic pressure regulated electrolyte.

[0044] Based on the above raw materials, the production step of hemodialysis concentrate is the same as that of the examples, and will not be explained herein.

[0045] Comparative Examples 1, II, two, from the preparation of high purity hemodialysis concentrate, the effect of the secondary hydrogen carbonate hemodialysis is the most reasonable, so the content of the blood dialysate is the most reasonable. Calcium glorate 10g / L, citric acid 60g / L, heparin 25g / L, calcium chloride 20g / L, potassium chloride 20g / L, sodium chloride 100g / L, glucose 10g / ...

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Abstract

The invention discloses a high-purity hemodialysis concentrated solution and a preparation technology, and belongs to the technical field of hemodialysis concentrated solutions. The technological process is carried out in a separated concentration mode, so that the concentrated solution can be separately stored after being concentrated, and the concentrated solution can also be mixed according to steps, stored and diluted during use; the effect of separated concentration is more accurate than that of mixed concentration on the concentration proportion of each part, so that the mixed concentrated solution in the following step is better and more accurate in proportion when being used and diluted; blood dialysate containing 10 g / L of calcium chlorate, 60 g / L of citric acid, 25 g / L of heparin, 20 g / L of calcium chloride, 20 g / L of potassium chloride, 10 g / L of magnesium chloride, 100 g / L of sodium chloride, 10 g / L of glucose, 950 mg / L of ferric citrate, 3000 mg / L of sodium iron gluconate and osmotic pressure adjusting electrolyte are adopted, so that the blood calcium content and the iron supplementing function can be better maintained, and osmotic pressure can be adjusted.

Description

Technical field [0001] The present invention relates to a blood dialysis concentrate, and more particularly to a high-purity hemodialysis concentrate, and the present invention also relates to a preparation process of hemodialysis concentrate, and more particularly to a high-purity hemodialysis concentrate prepared, which belongs to blood. Dialysis of the technical field of concentrate. Background technique [0002] The dialysate is a solution containing a plurality of ions and nonionic substances having a certain osmotic pressure, rendering, intraperitoneal or in vitro dialysis. [0003] The blood dialysate in the prior art cannot be adjusted for the regulation of the acid alkalinity equilibrium when administered to the patient, and the conventional regulating liquid such as bicarbonate is mainly harmful to the human body. And it also affects blood calcium, and existing existing storage of hemodialysis is stored in a concentrated manner, while the process flow used in the concen...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/26A61P7/08A61K31/194A61K31/7004A61K31/727A61K33/00A61K33/06A61K33/14
CPCA61K31/194A61K31/727A61K33/14A61K33/06A61K31/7004A61K33/26A61K33/00A61P7/08A61K2300/00
Inventor 钟禄丰
Owner JIANGSU NAHAI BIOLOGICAL TECH CO LTD
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