Manganese-heme coordination polymer nano-particle and preparation method and application thereof

A technology of coordination polymers and nanoparticles, which is applied in the field of tumor diagnosis and treatment, can solve the problems of limited application, low spatial resolution, and limited penetration depth, and achieve broad application range, enhanced ferroptosis treatment effect, and good biological safety and the effect of relaxation properties

Active Publication Date: 2021-10-01
INNOVATION ACAD FOR PRECISION MEASUREMENT SCI & TECH CAS
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  • Abstract
  • Description
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  • Application Information

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Problems solved by technology

[0004] Although optical imaging technology has high sensitivity, its spatial resolution is usually low due to the scattering of light waves by biological tissues, and the penetration depth of light in biological tissues is limited, which greatly limits its application.

Method used

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  • Manganese-heme coordination polymer nano-particle and preparation method and application thereof
  • Manganese-heme coordination polymer nano-particle and preparation method and application thereof
  • Manganese-heme coordination polymer nano-particle and preparation method and application thereof

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Embodiment 1

[0039] 1. Weigh 160mg NaOH in 40ml ultrapure water, stir to dissolve, and prepare 0.1M NaOH solution;

[0040] 2. Weigh 8.2mg of hemin, add it to 25ml of 0.1M NaOH solution, sonicate until it is completely dissolved, adjust the pH of the system to 7, and obtain a 0.5mM hemin solution;

[0041] 3. Weigh 395.8mg MnCl 2 .4H 2 O was dissolved in 50ml ultrapure water and stirred to prepare 0.04M MnCl 2 solution;

[0042] 4. Mix 50ml 0.04M MnCl 2 The solution was slowly added dropwise to 25ml of hemin solution at a rotation speed of 1500rpm. After the addition was completed, the pH of the system was adjusted to 7, and then stirred at room temperature and at a rotation speed of 1500rpm for 1 hour to obtain a mixed solution;

[0043] 5. Transfer the mixed solution to a 100ml high-pressure reactor, heat it to 120°C, and conduct a hydrothermal reaction at 120°C for 3 hours. After the reaction, cool it down to room temperature naturally to obtain a mixed product;

[0044] 6. Centrif...

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Abstract

The invention discloses a manganese-heme coordination polymer nano-particle and a preparation method and application thereof, the nano-particle is formed by manganese ions and two specific carboxyl groups in heme through coordination polymerization, the nano-particle is of a cubic structure, and the average side length is about 20 nm. The preparation method comprises the following steps: in a NaOH solution with the pH value of 7, carrying out hydrothermal synthesis reaction on a manganese source and heme at 120 DEG C for 3 hours; the nano-particle is formed by self-assembly of manganese ions and heme, due to existence of iron and manganese elements, the nano-particle can be used for 1H-MRI imaging of tumors, meanwhile, the nano-particle has excellent photo-thermal conversion performance and can be used for photo-thermal therapy and photo-acoustic imaging of the tumors. Moreover, the nano-particle has nano-enzyme catalytic activity, H2O2 can be efficiently catalyzed through Fenton reaction to generate highly toxic. OH, lipid peroxidation in cells is caused, apoptosis or necrosis of the cells is promoted through a ferroptosis pathway, and then the nano-particles can be applied to CDT and Fe death treatment of tumors.

Description

technical field [0001] The invention belongs to the technical field of tumor diagnosis and treatment, and in particular relates to a manganese-heme coordination polymer nanoparticle and its preparation method and application. Background technique [0002] According to the 2020 global new cancer burden data recently released by the International Agency for Research on Cancer (IARC) of the World Health Organization, there will be 19.29 million new cancer cases and 9.96 million global cancer deaths in 2020. Cancer is still a threat to human health and The "number one enemy" of life. In the past, lung cancer has always been the cancer with the highest incidence rate in the world. The latest data in 2020 shows that the number of new breast cancers is 2.26 million, which is 2.2 million more than the number of new lung cancers. It surpasses lung cancer for the first time and ranks first in the incidence of cancer. However, in the statistics of global cancer deaths in 2020, the num...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/10A61K49/18A61K49/22A61K41/00A61K47/22A61P35/00
CPCA61K49/106A61K49/1833A61K49/225A61K49/221A61K41/0052A61K47/22A61P35/00
Inventor 周欣隋美菊陈世桢孙献平
Owner INNOVATION ACAD FOR PRECISION MEASUREMENT SCI & TECH CAS
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