Plant extract combined dressing based on ginseng extract and preparation method thereof

Abstract

The invention discloses a plant extract combined dressing based on ginseng extract and a preparation method thereof. During preparation, chitosan and polyoxyethylene serve as raw materials, a chitosan film is prepared through electrostatic spinning, the chitosan film serves as a dressing base film, chitosan has the characteristics of no toxicity, broad-spectrum antibacterial property, hemostasis, scar reduction, good biocompatibility and the like, so that chitosan is selected as a main raw material, and plant extracts are introduced; the plant extract is compounded by three combination modes of the ginseng extract and the radix ophiopogonis extract, the ginseng extract and the chrysanthemum extract and the ginseng extract and the artemisia apiacea extract, and matching and selection can be randomly carried out in actual operation. The process is reasonable in design and simple to operate, and the prepared combined dressing not only has excellent antibacterial performance, but also is non-toxic to a human body and good in biocompatibility, can promote healing of wounds on the skin surface during use, and has relatively high practicability.

Description

technical field

[0001] The invention relates to the technical field of dressings, in particular to a ginseng extract-based plant extract combined dressing and a preparation method thereof. Background technique

[0002] Medical dressing is a medical material that is widely used nowadays. It is a medical material that can target the actual situation of the wound and provide special functions for wound healing. As a wound covering, medical dressings can replace damaged skin to act as a temporary barrier during the wound healing process, which can avoid or control wound infection and provide a good healing environment for the wound.

[0003] Because chitosan has excellent non-toxic, antibacterial, and biocompatibility, chitosan film is generally used as dressing base film, and polydopamine layer is coated on the surface of chitosan film to increase the load of subsequent particles. However, the existence of the polydopamine layer will reduce the air permeability of the chitosan...

Examples

Embodiment 1

[0041] A preparation method of a plant extract combination dressing based on ginseng extract, comprising the following steps:

[0042] (1) Take zinc nitrate hexahydrate and ethanol, mix and stir for 20 minutes, add ethyl orthosilicate, stir evenly, and obtain material C;

[0043] Take cetyltrimethylammonium bromide and deionized water, mix and stir for 5 minutes, add ether, ethanol and ammonia water, continue stirring for 30 minutes, slowly add material C and 3-mercaptopropyltrimethoxysilane dropwise, and stir for 4 hours , the product was collected by centrifugation, washed with ethanol and deionized water in sequence, and dried in vacuum at 60°C; after drying, it was transferred to a mixed solution of ethanol and hydrochloric acid, refluxed at 68°C for 24 hours, washed and dried to obtain mesoporous silica.

[0044] Take mesoporous silica and N,N-dimethylformamide, ultrasonically disperse for 10 minutes to obtain material B; take KH-550, succinic anhydride and N,N-dimethylfo...

Embodiment 2

[0053] A preparation method of a plant extract combination dressing based on ginseng extract, comprising the following steps:

[0054] (1) Take zinc nitrate hexahydrate and ethanol, mix and stir for 25 minutes, add ethyl orthosilicate, stir evenly, and obtain material C;

[0055] Take cetyltrimethylammonium bromide and deionized water, mix and stir for 8 minutes, add ether, ethanol and ammonia water, continue stirring for 35 minutes, slowly add material C and 3-mercaptopropyltrimethoxysilane dropwise, and stir for 5 hours , the product was collected by centrifugation, washed with ethanol and deionized water in sequence, and dried in vacuum at 63°C; after drying, it was transferred to a mixed solution of ethanol and hydrochloric acid, refluxed at 69°C for 22 hours, washed and dried to obtain mesoporous silica.

[0056] Take mesoporous silica and N,N-dimethylformamide, ultrasonically disperse for 13 minutes to obtain material B; take KH-550, succinic anhydride and N,N-dimethylfo...

Embodiment 3

[0065] A preparation method of a plant extract combination dressing based on ginseng extract, comprising the following steps:

[0066] (1) Take zinc nitrate hexahydrate and ethanol, mix and stir for 30 minutes, add ethyl orthosilicate, stir evenly, and obtain material C;

[0067] Take cetyltrimethylammonium bromide and deionized water, mix and stir for 10 minutes, add ether, ethanol and ammonia water, continue stirring for 40 minutes, slowly add material C and 3-mercaptopropyltrimethoxysilane dropwise, and stir for 6 hours , the product was collected by centrifugation, washed with ethanol and deionized water in turn, and dried in vacuum at 65°C; after drying, it was transferred to a mixed solution of ethanol and hydrochloric acid, refluxed at 70°C for 20 hours, washed and dried to obtain mesoporous silica.

[0068] Take mesoporous silica and N,N-dimethylformamide, ultrasonically disperse for 15 minutes to obtain material B; take KH-550, succinic anhydride and N,N-dimethylforma...

technical field

[0001] The invention relates to the technical field of dressings, in particular to a ginseng extract-based plant extract combined dressing and a preparation method thereof. Background technique

[0002] Medical dressing is a medical material that is widely used nowadays. It is a medical material that can target the actual situation of the wound and provide special functions for wound healing. As a wound covering, medical dressings can replace damaged skin to act as a temporary barrier during the wound healing process, which can avoid or control wound infection and provide a good healing environment for the wound.

[0003] Because chitosan has excellent non-toxic, antibacterial, and biocompatibility, chitosan film is generally used as dressing base film, and polydopamine layer is coated on the surface of chitosan film to increase the load of subsequent particles. However, the existence of the polydopamine layer will reduce the air permeability of the chitosan...

Examples

Embodiment 1

[0041] A preparation method of a plant extract combination dressing based on ginseng extract, comprising the following steps:

[0042] (1) Take zinc nitrate hexahydrate and ethanol, mix and stir for 20 minutes, add ethyl orthosilicate, stir evenly, and obtain material C;

[0043] Take cetyltrimethylammonium bromide and deionized water, mix and stir for 5 minutes, add ether, ethanol and ammonia water, continue stirring for 30 minutes, slowly add material C and 3-mercaptopropyltrimethoxysilane dropwise, and stir for 4 hours , the product was collected by centrifugation, washed with ethanol and deionized water in sequence, and dried in vacuum at 60°C; after drying, it was transferred to a mixed solution of ethanol and hydrochloric acid, refluxed at 68°C for 24 hours, washed and dried to obtain mesoporous silica.

[0044] Take mesoporous silica and N,N-dimethylformamide, ultrasonically disperse for 10 minutes to obtain material B; take KH-550, succinic anhydride and N,N-dimethylfo...

Embodiment 2

[0053] A preparation method of a plant extract combination dressing based on ginseng extract, comprising the following steps:

[0054] (1) Take zinc nitrate hexahydrate and ethanol, mix and stir for 25 minutes, add ethyl orthosilicate, stir evenly, and obtain material C;

[0055] Take cetyltrimethylammonium bromide and deionized water, mix and stir for 8 minutes, add ether, ethanol and ammonia water, continue stirring for 35 minutes, slowly add material C and 3-mercaptopropyltrimethoxysilane dropwise, and stir for 5 hours , the product was collected by centrifugation, washed with ethanol and deionized water in sequence, and dried in vacuum at 63°C; after drying, it was transferred to a mixed solution of ethanol and hydrochloric acid, refluxed at 69°C for 22 hours, washed and dried to obtain mesoporous silica.

[0056] Take mesoporous silica and N,N-dimethylformamide, ultrasonically disperse for 13 minutes to obtain material B; take KH-550, succinic anhydride and N,N-dimethylfo...

Embodiment 3

[0065] A preparation method of a plant extract combination dressing based on ginseng extract, comprising the following steps:

[0066] (1) Take zinc nitrate hexahydrate and ethanol, mix and stir for 30 minutes, add ethyl orthosilicate, stir evenly, and obtain material C;

[0067] Take cetyltrimethylammonium bromide and deionized water, mix and stir for 10 minutes, add ether, ethanol and ammonia water, continue stirring for 40 minutes, slowly add material C and 3-mercaptopropyltrimethoxysilane dropwise, and stir for 6 hours , the product was collected by centrifugation, washed with ethanol and deionized water in turn, and dried in vacuum at 65°C; after drying, it was transferred to a mixed solution of ethanol and hydrochloric acid, refluxed at 70°C for 20 hours, washed and dried to obtain mesoporous silica.

[0068] Take mesoporous silica and N,N-dimethylformamide, ultrasonically disperse for 15 minutes to obtain material B; take KH-550, succinic anhydride and N,N-dimethylforma...

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