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A method for preparing janus particles and a method for controlling their morphology

A particle and morphology technology, which is applied in the field of preparation of Janus particles, simple synthesis of Janus particles without organic solvents, and new ideas for morphology control of Janus particles, which can solve complex equipment, large organic solvents, difficult to control morphology, etc. problems, to achieve the effect of simple preparation method, no need for complex equipment, and easy operation

Active Publication Date: 2022-04-01
HUAZHONG UNIV OF SCI & TECH
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

[0005] The problem to be solved by the present invention is to overcome the technical problems such as the consumption of a large amount of organic solvents, difficulty in controlling the morphology, and complicated equipment in the prior art for synthetic Janus particles. The purpose of the present invention is to provide a simple, effective and environmentally friendly all-water system Janus The preparation method of particles, and the geometry of Janus particles can be further controlled, so as to prepare Janus hydrogel particles with biocompatibility, green environmental protection and adjustable morphology to meet various design requirements

Method used

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  • A method for preparing janus particles and a method for controlling their morphology
  • A method for preparing janus particles and a method for controlling their morphology
  • A method for preparing janus particles and a method for controlling their morphology

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preparation example Construction

[0047] According to the purpose of the present invention, a kind of simple and easy synthetic method of Janus particle is provided, and the concrete steps of this method comprise:

[0048] (1) First, a certain volume of PEG solution added with NIPAm monomer, BIS co-crosslinking agent and photoinitiator is injected with a syringe on the surface of the superamphiphobic substrate prepared with soot. The contact angle is very large, so the PEG solution on the substrate appears as a sphere.

[0049] (2) Use a syringe to inject a certain volume of DEX solution added with NIPAm monomer, BIS co-crosslinking agent and photoinitiator onto the PEG droplet on the substrate. At this time, the PEG solution / DEX solution will form a full water system , we can use phase separation to form spherical Janus droplets, where the upper phase is a PEG-rich phase and the lower phase is a DEX-rich phase.

[0050] (3) Then the Janus droplets will aggregate into hydrogel Janus particles under ultraviole...

Embodiment 1

[0068] Take 0.5g of DEX (dextran) in a 25ml glass sample bottle, add 2ml of deionized water to dissolve it, put it into a magnet and stir, and the solution is clear at this time;

[0069] The syringe draws 5wt% PEG (polyethylene glycol) solution, records the syringe scale, and constantly injects the PEG solution until the solution is turbid (the concentration of the mixed two-phase solution is just on the coexistence curve at this time), records the syringe scale, and can obtain a Set the volume of PEG solution consumed to allow the two-phase solution to become turbid from clarification;

[0070]Then add an appropriate amount of deionized water until the solution is clear, and then continue to inject the PEG solution until the solution is turbid, record the syringe scale, and then get a set of PEG solution volumes consumed to make the two-phase solution from clear to turbid; repeat the operation, Record the experimental data, and you can get multiple groups of PEG solution vol...

Embodiment 2、3、4、5、6 and 7

[0074] Repeat the experimental operation of Example 1 with 0.5g DEX and 10wt%, 0.5g DEX and 20wt% PEG solution and 0.1g DEX and 15wt%, 30wt%, 40wt% PEG solution respectively, can obtain image 3 , Figure 4 , Figure 5 , Figure 6 , Figure 7 These six critical mass concentration data points.

[0075] in, image 3 and Figure 4 In the coexistence curve, the mass concentration of DEX is in the high concentration area, and the mass concentration of PEG is in the low concentration area. Figure 5 , Figure 6 , Figure 7 In the coexistence curve, the DEX mass concentration is located in the low concentration area, and the PEG mass concentration is located in the high concentration area. Integrating the data points in the low concentration area of ​​DEX with the data in the high concentration area of ​​DEX, a complete coexistence curve in the phase diagram of the PEG / DEX system can be obtained, as shown in Figure 8 shown.

[0076] The position and shape of the coexistenc...

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Abstract

The invention discloses a method for preparing Janus particles and a shape control method, belonging to the technical field of polymer composite materials. The first polymer solution containing monomer, co-crosslinking agent and photoinitiator is added dropwise to the surface of the superhydrophobic substrate to form droplets. Since the droplets will present a large contact angle on the surface of the superhydrophobic substrate, the The droplet is spherical; then the second polymer solution containing monomer, co-crosslinking agent and photoinitiator is added dropwise to the surface of the droplet to form a mixed droplet, and the mixed droplet undergoes phase separation to form a spherical Janus droplet; Under light, Janus droplets will aggregate into hydrogel Janus particles. The invention effectively solves the problems that the synthetic Janus particles need to consume a large amount of organic solvents, it is difficult to control the shape and the equipment is complex, and can be used to synthesize Janus particles with complex shapes that meet the needs of users.

Description

technical field [0001] The present invention relates to the technical field of polymer composite materials, more specifically, to a method for preparing Janus particles and a method for controlling their morphology, in particular to a simple synthesis method of Janus particles without organic solvents that can be applied in the field of drug delivery and to A new idea of ​​Janus particles for morphology control. Background technique [0002] Janus particle is a partition colloid with two or more different chemical properties or compositions. Due to the asymmetric structure of Janus particles, which can integrate different functional properties and perform more synergistic functions at the same time, it has a wide range of application prospects, and can be applied to environment-responsive carriers, self-assembly, microrheological probes, solid surface active medicines and other fields. At the same time, due to the difference in perception and response ability of Janus part...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01J2/06B01J13/00
CPCB01J2/06B01J13/0065
Inventor 黄才利陈静怡程泉勇朱天任余祥
Owner HUAZHONG UNIV OF SCI & TECH
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