A kind of preparation method of anisotropic hydrogel
An anisotropic, hydrogel technology, applied in the field of multifunctional hydrogel preparation, can solve the problems of lack of ordered structure and limited application of hydrogel, and achieve the effect of good biocompatibility, high strength and toughness
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Image
Examples
preparation example Construction
[0024] The present invention is an anisotropic hydrogel preparation method, specifically implemented in accordance with the following steps:
[0025] Step 1, mix gelatin with deionized water, put into a thermostatic shaker for reaction, make it fully dissolved, and obtain gelatin solution;
[0026] The mass ratio of gelatin to deionized water is 0.1-4:2-5;
[0027] The reaction temperature is 30-100 °C, and the reaction time is 10-120min;
[0028] Step 2, dissolve the photoinitiator in deionized water to obtain a photoinitiator solution;
[0029] The photoinitiators are bP, 4-diethylthioanthrasterone, or 2-hydroxy-4'-(2-hydroxyethoxy)-2-methylpropiophenone;
[0030] The mass ratio of photoinitiator to deionized water is 0.0001-1:1-10;
[0031] Step 3, the N-isopropyl methacrylamide monomer is mixed with deionized water, placed in the ultrasonic oscillator to shake and dissolve, after dissolution, crosslinking agent N, N-methylene bisacrylamide is added, and finally the photoinitia...
Embodiment 1
[0039] The present invention is an anisotropic hydrogel preparation method, specifically implemented in accordance with the following steps:
[0040] Preliminary preparation: Weigh 1.5g gelatin in a beaker, take 3.5mL of deionized water and dissolve it at 40 °C for 30 minutes. Then take 10mL of deionized water and stir 0.005g of photoinitiator in a glass to dissolve and set aside.
[0041] Material treatment: Accurately weigh the monomer NIPMAM 0.2g, add 3mL deionized water, placed in the ultrasonic shaker to dissolve for 20min, after dissolution, add the crosslinking agent MBAA 0.0243g, and finally add 1mL photoinitiator solution, mix evenly; pour the polymer mixing solution into the gelatin solution, slowly stir for 3min to make it mix thoroughly.
[0042] Lithography reaction: Finally weigh 0.0075g TG enzyme using 1mL deionized water to dissolve, dropwise add enzyme solution to the mixture, until the mixture is completely dissolved and basically no more bubbles after pouring in...
Embodiment 2
[0044] The present invention is an anisotropic hydrogel preparation method, specifically implemented in accordance with the following steps:
[0045] Preliminary preparation: Weigh 2g gelatin in a beaker and take 4mL of deionized water to dissolve at 45 °C for 35 min. Then take 10mL of deionized water and stir 0.01g of photoinitiator in a glass to dissolve.
[0046] Material treatment: accurately weigh the monomer NIPMAM 0.1g, add 3mL deionized water, placed in the ultrasonic shaker to dissolve for 40min, after dissolution added crosslinker MBAA 0.028g, and finally add 1mL photoinitiator solution, mix evenly; pour the polymer mixing solution into the gelatin solution, slowly stir for 5min to make it mix thoroughly.
[0047] Lithography reaction: Finally weigh 0.01g TG enzyme using 1mL deionized water to dissolve, dropwise add enzyme solution to the mixture, until the mixture is completely dissolved and basically no more bubbles after pouring into the mold, and then clamped at both e...
PUM
| Property | Measurement | Unit |
|---|---|---|
| modulus | aaaaa | aaaaa |
| tensile stress | aaaaa | aaaaa |
| tensile stress | aaaaa | aaaaa |
Abstract
Description
Claims
Application Information
Login to View More 
PatSnap Eureka turns technology decisions into work you can execute. Powered by our Innovation Knowledge Graph, it runs expert workflows across engineering, life sciences, materials and intellectual property. Get your review-ready output in minutes.
