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Application of sesamin in preparation of medicine for treating spermatogenic dysfunction

A technology of dysfunction and sesamin, applied in the field of reproductive system diseases, can solve the problems of high or low risk of birth defects in offspring, pregnancy rate is only 4%-40%, and achieve the effect of improving spermatogenic dysfunction

Pending Publication Date: 2021-10-08
NINGXIA MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although assisted reproductive technology (Assisted Reproductive Technology, ART) provides the possibility of fertility for patients with testicular spermatogenic dysfunction, the success rate of ART technology is still low, the pregnancy rate is only 4%-40%, and the offspring have birth defects higher risk than natural pregnancy

Method used

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  • Application of sesamin in preparation of medicine for treating spermatogenic dysfunction
  • Application of sesamin in preparation of medicine for treating spermatogenic dysfunction
  • Application of sesamin in preparation of medicine for treating spermatogenic dysfunction

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] The use of sesamin in the preparation of medicines for treating spermatogenic dysfunction, wherein the single application dose of sesamin is 50 mg / kg for mice, and the dosage form of the medicine is an oral dosage form.

Embodiment 2

[0036] The application of sesamin in the preparation of medicine for treating spermatogenesis dysfunction, wherein, the single application dose of sesamin is 100 mg / kg for mice, and the dosage form of the medicine is an oral dosage form.

Embodiment 3

[0038] The use of sesamin in the preparation of medicines for treating spermatogenesis dysfunction, wherein the single application dose of sesamin is 200 mg / kg for mice, and the dosage form of the medicine is an oral dosage form.

[0039] The following animal experiment has further illustrated the effect of above-mentioned embodiment 1 to 3:

[0040] 1. Experimental materials

[0041] 1.1 Animal handling

[0042] SPF-grade ICR male adult mice weighing between 23-27g were bred by the Experimental Animal Center of Ningxia Medical University (animal incubation qualified batch number: SCXK (Ning) 2020-0001). Animals were fed according to the experimental animal feeding standards, and the feeding room was artificially controlled to alternate day and night for 12 hours, and the mice drank water freely.

[0043] 1.2 Experimental drugs and instruments

[0044] The main drugs and reagents involved in this experiment include: sesamin (purchased from Shanghai Yuanye Biological Company, ...

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Abstract

The invention provides application of sesamin in preparation of a medicine for treating spermatogenic dysfunction. Experimental results show that sesamin can significantly improve the number and vitality of sperms; the RNF8-ubH2A / ubH2B pathway in the testis can be significantly inhibited, and has a protective effect on mice with spermatogenic dysfunction.

Description

technical field [0001] The application belongs to the field of reproductive system diseases, and specifically, the application provides the use of sesamin in the preparation of medicines for treating spermatogenesis dysfunction. Background technique [0002] Affected by many factors such as genetics and environmental pollution, the incidence of male infertility is gradually increasing, reaching as high as 10% to 15%, becoming the third major factor that endangers human health and social stability after tumors and cardiovascular diseases . Therefore, the reproductive health of infertile people is also regarded as a public health issue that must be paid close attention to worldwide. Male infertility mainly includes spermatogenesis dysfunction, sexual dysfunction, endocrine disorders and testicular tissue damage. Among the clinically infertile patients, most of them showed testicular spermatogenic dysfunction. The etiology of testicular spermatogenesis disorder is complex, a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/36A61P15/08A23L33/00
CPCA61K31/36A61P15/08A23L33/00A23V2002/00A23V2200/30
Inventor 余建强海冬梅杨佳美任家玮池彦南刘宁马琳兰小兵杜娟
Owner NINGXIA MEDICAL UNIV
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