Synthesis and detection method of novel tertiary amine modified antibacterial pit and fissure sealing agent

Abstract

The invention belongs to the technical field of oral clinic, and discloses a synthesis and detection method of a novel tertiary amine modified antibacterial pit and fissure sealing agent. According to the method, a pit and fissure sealing agent is prepared, the dosage relation between DMAEM and Clinpro is screened according to the photocuring depth of a modified resin pit and fissure sealing agent material, and the optimal dosage range is screened through experiments; on the basis, a performance detection sample is selected, and a cytotoxicity experiment, surface roughness detection and microhardness detection are performed; the influence of the DMAEM on the material performance and the anti-caries performance of the pit and fissure sealing agent is investigated by taking a plurality of performances such as cytotoxicity, hardness, surface roughness, antibacterial performance and the like as indexes; and a saliva biofilm is cultured in vitro, the modified resin sealing agent is subjected to biological aging, antibiosis before and after biological aging is detected, and the micro-leakage condition of the pit and fissure sealing agent subjected to biological aging is detected. According to the invention, the sealing agent has a long-acting and sustainable antibacterial effect, and overcomes the defects of the existing pit and fissure sealing agent.

Description

technical field [0001] The invention belongs to the field of oral clinical technology, and in particular relates to a synthesis and detection method of a novel antibacterial pit and fissure sealant modified by a tertiary amine. Background technique [0002] At present, dental caries is a chronic infectious disease that seriously affects the health of human oral cavity and even the whole body. According to the research results of the global burden of disease published by the famous medical authoritative journal "The Lancet", among 328 major diseases, the incidence of dental caries in permanent teeth ranks second, and the incidence of dental caries in deciduous teeth ranks fifth. In my country, children's caries is on the rise. According to the fourth national oral health epidemiological survey, the prevalence rate of permanent tooth caries in 12-year-old children is 34.5%, which is 7.8 percentage points higher than ten years ago. The caries rate of deciduous teeth of 5-year-...

AI Technical Summary

Problems solved by technology

[0007] (1) The current clinical challenge of light-curing composite resin pit and fissure sealant is that it does not have long-term anti-caries ability, and more plaque biofilms may accumulate on its surface, causing caries to occur

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