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A method for early warning of ischemic stroke

An ischemic stroke, serum technology, applied in the medical field, can solve the problems of unwarranted complications and other problems

Active Publication Date: 2022-08-09
TIANJIN UNIV OF TRADITIONAL CHINESE MEDICINE +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Atherosclerosis is the cause of stroke. The occurrence and development of atherosclerosis is a slow and gradual process, but its complications are usually without warning

Method used

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  • A method for early warning of ischemic stroke
  • A method for early warning of ischemic stroke
  • A method for early warning of ischemic stroke

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Experimental program
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Embodiment 1

[0032] Example 1 A method for early warning of ischemic stroke

[0033] 1. Materials and methods

[0034] 1. Experimental instruments and reagents

[0035] Distilled water (Guangzhou Watsons Food & Beverage Co., Ltd.), chromatographically pure acetonitrile (Oceanpak Company, Sweden), chromatographically pure formic acid (ROE Company, USA) low-temperature high-speed centrifuge (Changsha Xiangyi Centrifuge Instrument Co., Ltd.), JKYMEN ultrasonic cleaner, small Oscillating vortex (Haimen Qilin Bell Instrument Manufacturing Co., Ltd.), Waters Acquity UPLC liquid chromatograph (Waters, USA), Waters Xevo G2S Q-TOF mass spectrometer (Waters, USA), ACQUITYUPLC BEH C18 chromatographic column (2.1×100 mm, 1.7 μm, Waters Corporation, USA).

[0036] 2. Experimental method

[0037] (1) Experimental grouping

[0038] In the experiment, a total of 400 subjects participated, including atherosclerosis index 4 (G), ischemic stroke atherosclerosis index 4 (SG) four groups. Serum samples we...

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Abstract

The invention discloses an ischemic stroke early warning method, which belongs to the field of medicine. The present invention analyzes serum samples based on UPLC‑Q / TOF‑MS technology and metabolomics method, screens out candidate biomarkers for atherosclerosis-induced ischemic stroke, and combines the candidate markers with atherosclerosis Sclerosis-like index for early warning of ischemic stroke. The present invention determines five potential biomarkers in the serum of atherosclerosis-induced ischemic stroke through multivariate statistical analysis, and realizes the potential biomarkers combined with atherosclerosis index into the diagnosis and treatment of ischemic stroke. Treatment provides an early warning effect.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a method for early warning of ischemic stroke, in particular to a method for early warning of ischemic stroke by atherosclerosis index combined with serum metabolites. Background technique [0002] Stroke, also known as cerebral stroke, cerebrovascular accident, is an acute cerebral blood circulation disorder caused by stenosis, occlusion or rupture of intracerebral arteries caused by various predisposing factors. Stroke is currently one of the major diseases threatening global human health, and has become the second leading cause of death in the world. Stroke is divided into ischemic stroke (IS) and hemorrhagic stroke, and ischemic stroke is the main one. Ischemic stroke refers to ischemic necrosis or encephalomalacia of limited brain tissue caused by cerebral blood supply disorder, ischemia and hypoxia. Ischemic stroke mainly originates from atherosclerosis, which leads to a series of...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/88
CPCG01N30/88G01N2030/8822
Inventor 李遇伯杨珅珅孙桂江
Owner TIANJIN UNIV OF TRADITIONAL CHINESE MEDICINE