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Application of cca-cd co-assembly in the preparation of macromolecular toxin detoxification drugs

A technology of co-assembly and supramolecular assembly, applied in the direction of drug combination, nano-drugs, anti-toxic agents, etc., to achieve high chemical and thermal stability, clear chemical structure, and good biocompatibility

Active Publication Date: 2022-07-19
NANKAI CANGZHOU BOHAI NEW AREA GREENING CHEM RES CO LTD
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] The purpose of the present invention is to solve the specific and strong bonding of macromolecular toxins, thereby effectively alleviating their toxicity

Method used

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  • Application of cca-cd co-assembly in the preparation of macromolecular toxin detoxification drugs
  • Application of cca-cd co-assembly in the preparation of macromolecular toxin detoxification drugs
  • Application of cca-cd co-assembly in the preparation of macromolecular toxin detoxification drugs

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Embodiment Construction

[0031] The present invention will be further described in detail below through specific examples. The following examples are only descriptive, not restrictive, and cannot limit the protection scope of the present invention.

[0032] A co-assembly CCA-CD capable of heteropolyvalent recognition has the potential to treat macromolecular toxin poisoning such as melittin. The carboxyl-modified amphiphilic calixarene CCA and amphiphilic cyclodextrin CD are used as the building blocks of the heteropolyvalent recognition platform.

[0033] Among them, the chemical formula of CCA is C 100 H 150 O 15 , the chemical formula of CD is C 182 H 350 O 56 S 7 , the molar ratio of the two substances is 1:1, the construction of supramolecular assemblies is through weak π-π interaction and hydrophobic interaction, and its scale is nanoscale and the shape is spherical vesicles. The structural formulas of CCA and CD are as follows:

[0034]

[0035] The preparation steps are as follows: ...

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Abstract

The invention relates to the application of a CCA-CD co-assembly in the preparation of macromolecular toxin detoxification drugs. The co-assembly CCA‑CD can effectively complex melittin, spider venom and snake venom to alleviate their cytotoxicity, and has the potential to treat the poisoning of these toxic macromolecules. Each component of CCA-CD has a clear chemical structure and good batch reproducibility. CCA-CD has high chemical stability and thermal stability, and does not affect the activity of important proteins in organisms, and has good biocompatibility.

Description

technical field [0001] The invention belongs to the technical field of nano-supramolecular materials, and relates to a supramolecular co-assembly, in particular to a nano-supramolecular co-assembly using an amphiphilic calixarene CCA and an amphiphilic cyclodextrin CD through heteropolyvalent action, and an alkaline-rich co-assembly. The macromolecular toxins of amino acids and hydrophobic amino acids achieve strong bonding and can be used for the detoxification of such macromolecular toxins. Background technique [0002] Poisoning is one of the main causes of emergency and intensive care units. For severe poisoning, the current treatment methods mainly include gastric lavage, enema, dialysis, etc., see: 1) Megarbane, B.; Oberlin, M.; Alvarez, J.C.; et al. Ann. Intensive Care 2020, 10, 157. 2) Mokhlesi, B.; Leiken, J. B.; Murray, P.; et al. Chest 2003, 123, 577-592. biological activity of the substance. This method has less requirements for toxins (such as the distribution...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/795A61P39/02C08G83/00C08B37/16B82Y5/00
CPCA61K31/795A61P39/02C08G83/008C08B37/0012B82Y5/00
Inventor 郭东升潘雨辰岳宇昕李华斌
Owner NANKAI CANGZHOU BOHAI NEW AREA GREENING CHEM RES CO LTD
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