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Preparation method for converting hydroxyapatite nanospheres into microrods

A technology of hydroxyapatite and nanospheres, which is applied in the direction of nanotechnology, chemical instruments and methods, phosphorus compounds, etc., can solve the problems of low output and complicated preparation methods of HA ceramic powder, achieve low cost, and promote the commercialization process , good stability

Pending Publication Date: 2021-10-22
XIAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The preparation methods of the HA ceramic powder prepared above are too complicated, and the output of the preparation is also low.

Method used

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  • Preparation method for converting hydroxyapatite nanospheres into microrods
  • Preparation method for converting hydroxyapatite nanospheres into microrods
  • Preparation method for converting hydroxyapatite nanospheres into microrods

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preparation example Construction

[0025] A preparation method for transforming hydroxyapatite nanospheres into microrods provided by the invention, such as figure 1 As shown in the process flow chart, the specific operation steps are as follows:

[0026] Step 1, prepare calcium salt solution: weigh 28.036g CaCl 2 In a beaker, add 100mL deionized water and stir for 10-30min with a magnetic stirrer to obtain a calcium salt solution;

[0027] Step 2, prepare oxalic acid solution: weigh 6.335g C 2 h 2 o 4 2H 2 0 and add 70mL deionized water, use a magnetic stirrer to stir for 5-15min to obtain a colorless and transparent oxalic acid solution;

[0028] Step 3, prepare mixed solution: weigh 20.009g (NH 4 ) 2 HPO 4 Add it to the oxalic acid solution obtained in step 2, and use a magnetic stirrer to stir for 10-30 minutes until it is completely dissolved to obtain a mixed solution;

[0029] Step 4, preparing an alkaline solution: Weigh 20.833g of NaOH powder, add the weighed NaOH powder into 50mL deionized wa...

Embodiment 1

[0034] Step 1, prepare calcium salt solution: weigh 28.036g CaCl 2 In a beaker, add 100mL deionized water and stir for 10min with a magnetic stirrer to obtain a calcium salt solution;

[0035] Step 2, prepare oxalic acid solution: weigh 6.335g C 2 h 2 o 4 2H 2 0 and add 70mL deionized water, use a magnetic stirrer to stir for 5min to obtain a colorless and transparent oxalic acid solution;

[0036] Step 3, prepare mixed solution: weigh 20.009g (NH 4 ) 2 HPO 4 Add to the oxalic acid solution obtained in step 2, and stir for 10 minutes using a magnetic stirrer to obtain a mixed solution;

[0037] Step 4, preparing an alkaline solution: Weigh 20.833g of NaOH powder, add the weighed NaOH powder to 50mL deionized water in 5 times, and stir for 20min with a magnetic stirrer to obtain an alkaline solution;

[0038] Step 5, add the mixed solution obtained in step 3 to the calcium salt solution obtained in step 1, stir with a magnetic stirrer for 10 minutes, then add the alkali...

Embodiment 2

[0042] Step 1, prepare calcium salt solution: weigh 28.036g CaCl 2 In a beaker, add 100mL deionized water and stir for 15min with a magnetic stirrer to obtain a calcium salt solution;

[0043] Step 2, prepare oxalic acid solution: weigh 6.335g C 2 h 2 o 4 2H 2 0 and add 70mL deionized water, use a magnetic stirrer to stir for 10min to obtain a colorless and transparent oxalic acid solution;

[0044] Step 3, prepare mixed solution: weigh 20.009g (NH 4 ) 2 HPO 4 Add to the oxalic acid solution obtained in step 2, and stir for 15 minutes using a magnetic stirrer to obtain a mixed solution;

[0045] Step 4, prepare alkaline solution: weigh 20.833g NaOH powder, add the weighed NaOH powder into 50mL deionized water in 6 times, and stir for 25min with a magnetic stirrer to obtain an alkaline solution;

[0046] Step 5, add the mixed solution obtained in step 3 to the calcium salt solution obtained in step 1, stir with a magnetic stirrer for 15 minutes, then add the alkaline so...

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Abstract

The invention relates to a preparation method for converting hydroxyapatite nanospheres into microrods, and belongs to the technical field of biological ceramic materials. According to the method, calcium chloride (CaCl2) is adopted as a calcium salt, diammonium hydrogen phosphate ((NH4)2HPO4) is adopted as a phosphate, oxalic acid (C2H2O4.2H2O) is added, an HA precursor solution is obtained through a rotary evaporation reaction under a high-concentration alkaline condition, the precursor powder is washed with water and alcohol, vacuum drying is performed, and then high-temperature calcination is performed to successfully prepare hydroxyapatite with different morphologies. In the synthesis process, common inorganic salts and simple reagents are mainly used, so that the method is low in cost, simple and feasible, good in repeatability, high in synthesis performance, good in stability, suitable for large-scale production and capable of promoting the commercialization process of biological ceramic materials.

Description

technical field [0001] The invention belongs to the technical field of bioceramic materials, and in particular relates to a preparation method for transforming hydroxyapatite nanospheres into microrods. Background technique [0002] Hydroxyapatite (Ca 10 (PO 4 ) 6 (OH) 2 , HA) is an inorganic component of human bones and teeth, has good biocompatibility and biological activity, and has been clinically used in the repair of bone defects. It can form osseointegration with human living tissue through bone conduction mechanism. In addition, HA is also of great interest in other non-biological fields, such as catalysis and water treatment. The application of hydroxyapatite material mainly depends on its structure, size and morphology. At present, people have prepared HA with different morphologies for different application fields. For example, Chinese patent CN100441503C discloses a preparation method of ionothermal synthesis of nano-HA. First, choose calcium nitrate and ...

Claims

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Application Information

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IPC IPC(8): C01B25/32B82Y40/00C04B35/447C04B35/626
CPCC01B25/325B82Y40/00C04B35/447C04B35/626C01P2004/10C01P2004/61C01P2004/32C01P2004/64C04B2235/3208
Inventor 焦华周雪蕊赵康汤玉斐靳洁晨张鑫媛
Owner XIAN UNIV OF TECH
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