Pharmaceutical composition for treating or preventing oral diseases

A composition and drug technology, applied in the directions of drug combination, oral care, pharmaceutical formula, etc., can solve the problems of difficulty in ensuring industrialization, complex preparation process, and numerous flavors of medicinal materials, and achieve good taste, high long-term safety, long-term conform to good effect

Pending Publication Date: 2021-10-26
SICHUAN JISHENGTANG PHARMLS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are often as many as ten or dozens of medicinal materials in the numerous Chinese medicine compositions for preventing or treating oral diseases disclosed at present. A gargle made from 9 herbs such as lotus leaf and coptis, patent application CN101524484A uses knotweed, honeysuckle, burnet, comfrey, hedyotis diffusa, cordyceps, musk, ginkgo, bamboo leaves, black sesame, pure jujube flower peaks An ointment made of 19 medicinal materials such as honey, mint, perilla leaf, mulberry leaf, mulberry bark, chrysanthemum, chrysanthemum, mulberry seed, etc. , Artemisia annua, Rhizoma Imperatae, Eclipta, Fritillaria, Tangerine Peel, Bamboo Leaf, Honeysuckle, Forsythia, Green Fruit, Sophora, Pulsatilla, Golden Buckwheat, Black Tea, Peppermint, Green Tea Extract, Vitamin B 2 Lozenges made of 21 medicinal materials such as 1-3, patent application CN105687906A. , Du Heng, Bamboo Ginseng, Coix Seed, Shui Tuan Hua, Purple Pearl and other 16 herbs. Herbal tea made from 17 medicinal materials including rattan, dandelion, lotus leaf, mulberry leaf, chrysanthemum, licorice, honeysuckle, skullcap, prunella vulgaris, Chuanxiong, and light bamboo leaves are all big prescriptions of traditional Chinese medicine. However, the medicinal materials used have many flavors, the preparation process is complicated, and its quality is difficult to guarantee. Industrialization is difficult. Third, whether there will be adverse reactions after long-term use has not been verified, especially in long-term use of oral care, plant beverages, health products, etc. It is more difficult to carry out commercial development in the field of big health products

Method used

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  • Pharmaceutical composition for treating or preventing oral diseases
  • Pharmaceutical composition for treating or preventing oral diseases
  • Pharmaceutical composition for treating or preventing oral diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0060] Embodiments of the present invention will be described in detail below in conjunction with examples, but those skilled in the art will understand that the following examples are only for illustrating the present invention, and should not limit the scope of the present invention. The Scutellaria baicalensis extract used in the present invention can be extracted through the extraction process described in "Chinese Pharmacopoeia (2015 Edition)" or can be obtained commercially. Those who do not indicate the specific conditions in the examples, continue to twist according to the conventional conditions or the conditions suggested by the manufacturer. All reagents or instruments provided without manufacturer’s indication are commercially available conventional products. Below in conjunction with embodiment the feature of the present invention and performance are described in further detail: Embodiment 1: the preparation technology of light bamboo leaf extract, mulberry leaf e...

Embodiment 2

[0067] Embodiment 2, antibacterial effect and mouthfeel evaluation test

[0068] 1. Antibacterial activity of different ratios of active ingredients of the Chinese medicine composition of the present invention to periodontal pathogenic bacteria anaerobic bacteria

[0069] Anaerobic bacteria selection: Porphyromonas gingivalis (Porphyromonas.gingivalis, Pg) ATCC 33277,

[0070] Preparation of the test sample mother board: the active ingredients of the Chinese medicine composition of the present invention are provided by Sichuan Jishengtang Pharmaceutical Co., Ltd., and the weight percentages of each component are as follows;

[0071]

[0072]

[0073] Prepare test A, B, C with sterile water to make 100mg / ml mother solution, use DMSO to make test D into 400mg / ml mother solution, and make 100mg / ml according to the weight percentage of each component mentioned above. In a 96-deep well plate, use the corresponding solvent of the test product to perform 2-fold gradient diluti...

Embodiment 3

[0103] Preparation of toothpaste:

[0104] Prescription: 56g sorbitol, 10g glycerin, 16g hydrated silica, 2g sodium lauryl sulfate, 1.5g mint essence, 0.9g xanthan gum, 0.24g sodium fluoride, 0.2g sodium benzoate, 0.2g menthone glycerin ketal , Sucralose 0.14g, Scutellaria Baicalensis Extract 0.14g, Mulberry Leaf Extract 0.12g, Lotus Leaf Extract 0.12g, Bamboo Leaf Extract 0.12g, Borneol 0.01g, Menthol 0.01g, Purified Water 12.3g.

[0105] Production Method:

[0106] 1. Take the prescribed amount of sorbitol and vacuum inhale the main pot;

[0107] 2. Premixing: Dissolve the prescribed amount of sodium fluoride, sodium benzoate, baicalin extract, sucralose, light bamboo leaf extract, and lotus leaf extract with the prescribed amount of purified water first, stir the solution until dissolved, and premix for later use Add the prescribed amount of xanthan gum to the prescribed amount of glycerin, stir until it is evenly dispersed, and obtain the premixed second for later use; t...

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Abstract

The invention provides a pharmaceutical composition and application thereof, and an oral care product, a health care product, a medicine and a plant beverage containing the pharmaceutical composition, so as to prevent, improve or treat oral diseases such as periodontitis, dental ulcer, gingival inflammation and bad breath. The pharmaceutical composition contains a lophatherum gracile extract, a mulberry leaf extract, a lotus leaf extract and a radix scutellariae extract. The pharmaceutical composition has prevention, improvement and treatment effects on oral related diseases such as the periodontitis, the dental ulcer, the gingival inflammation and the bad breath, and can be applied to preparation of medicines, health care products, oral care products and plant beverages for treating, preventing or improving the oral diseases such as the gingival inflammation, gingival bleeding, the periodontitis or the dental ulcer.

Description

technical field [0001] The invention relates to the fields of daily chemical products, health care products and medicines, in particular to a pharmaceutical composition for treating or preventing oral diseases and its application. Background technique [0002] Oral health is an important part of general health, directly or indirectly. Common oral diseases in humans include dental caries, periodontal disease, and oral mucosal disease. A large number of studies in the world have shown that the pathogenic bacteria of periodontal disease are strongly correlated with the incidence of coronary heart disease, diabetes and periodontal disease have common risk factors, and they are high risk factors for each other. The bacteria in the oral cavity of patients with oral diseases are continuously transported to the digestive tract, which may cause gastrointestinal diseases, and the secretion of oral bacteria into the lungs may cause aspiration pneumonia. [0003] At present, it is bel...

Claims

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Application Information

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IPC IPC(8): A61K36/899A61P1/02A61K8/9789A61K8/9794A61K8/60A61Q11/00A23L33/105A23L2/38
CPCA61K36/899A61K36/605A61K36/62A61K36/539A61K31/7048A61P1/02A61K8/9789A61K8/9794A61K8/602A61Q11/00A23L33/105A23L2/38A61K2236/331A61K2236/53A61K2236/39A61K2800/805A23V2002/00A61K2300/00A23V2200/312A23V2200/30A23V2250/21A23V2300/14A23V2250/262A23V2250/264Y02A50/30
Inventor 柯潇刘强代军平
Owner SICHUAN JISHENGTANG PHARMLS
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