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Application of polyketone compound in treatment of metabolic disorder related diseases

A compound and disease technology, applied in the field of medicine, can solve problems such as exacerbating the risk of cardiovascular and cerebrovascular diseases in the liver, and achieve important clinical application value

Pending Publication Date: 2021-11-02
XIAMEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This will further cause or exacerbate the risk of liver and cardiovascular and cerebrovascular diseases

Method used

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  • Application of polyketone compound in treatment of metabolic disorder related diseases
  • Application of polyketone compound in treatment of metabolic disorder related diseases
  • Application of polyketone compound in treatment of metabolic disorder related diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0060] The preparation of embodiment 1 compound

[0061] Those skilled in the art can refer to the following methods to prepare the compounds described in the present application, or refer to the methods in the prior art to obtain the compounds described in the present application, for example, Liu W, Gu Q, Zhu W, Cui C, FanG. Dihydrotrichodimerol and tetrahydrotrichodimerol , two new bisorbicillinoids, from a marine-derived Penicillium terrestre. J Antibiot (Tokyo). 2005; 58 (10): 621-4.

[0062] 1.1 Materials and Instruments

[0063] (1) strain

[0064] Strain MMF4 (Acremonium citrinum), isolated from sea mud (Wenzhou Aojiang Haikou beach).

[0065] (2) Experimental equipment:

[0066]

[0067] (3) Main reagents:

[0068]

[0069]

[0070] (4) culture medium

[0071] Rice medium: 100g rice, 150mL artificial sea water;

[0072] 1.2 Preparation of strain fermentation product

[0073] (1) Prepare 4800g of rice culture medium;

[0074] (2) Culture in a mold incuba...

Embodiment 2

[0089] Activity detection of embodiment 2 compound

[0090] 2.1 Main Instruments

[0091] EchoMRI-100H body composition analyzer, Covaris M220 automatic focusing ultrasonic breaker, BS-240vet automatic biochemical analyzer, LEICA EG1160 paraffin embedding machine, Leica DM4B upright microscope, OHAUS analytical balance, blood glucose meter For the Roche blood glucose meter.

[0092] 2.2 Main materials

[0093] Blood glucose test strips were purchased from Roche; serum total cholesterol, total triglycerides, high-density lipoprotein, and low-density lipoprotein detection kits were purchased from Kuber Company; high-fat feed (TP23400) and low-fat and low-sugar control feed (TP23402) were purchased from Nantong Trophy Co., Ltd.

[0094] 2.3 Animals

[0095] C57BL mice were purchased from the Experimental Animal Center of Xiamen University, which conformed to the ethical standards of experimental animals. After the mice were 3 months old, the control group was given a low-fat...

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Abstract

The invention relates to application of a polyketone compound in treatment of metabolic disorder related diseases, in particular to application of a compound shown as a formula I, a tautomer of the compound and pharmaceutically acceptable salt or ester of the compound in preparation of drugs, and the drugs are used for preventing or treating lipid and / or glucose metabolic disorder related diseases.

Description

technical field [0001] The invention relates to the field of medicine, in particular to the application of polyketide compounds in treating diseases related to metabolic disorders (such as sugar and / or lipid metabolism disorders). Background technique [0002] Metabolic disorder refers to a pathological state in which the body's glucose, lipid and / or protein metabolism is abnormal, resulting in an imbalance between supply and demand. With the change of diet structure and lifestyle, obesity, insulin resistance, hypercholesterolemia, non-alcoholic fatty liver, etc. caused by metabolic disorders have become epidemic diseases worldwide. The important clinical manifestations of this type of disease are increased body weight, increased body fat percentage, increased postprandial blood sugar but difficulty in regulating blood sugar with insulin, increased fat in the liver and abnormal hypertrophy of the liver. This will further cause or aggravate the risk of liver and cardiovascul...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/357A61P3/10A61P3/06A61P3/04A61P3/00A61P1/16A61P9/00A61P9/12A61P9/10A61P5/48
CPCA61K31/357A61P3/10A61P3/06A61P3/04A61P3/00A61P1/16A61P9/00A61P9/12A61P9/10A61P5/48
Inventor 周虎林挺陈永炎陈杰波高硕曾志平刘聪巍
Owner XIAMEN UNIV
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