Bone repairstentfor directionally inducing bone tissue differentiation

Abstract

The invention belongs to the technical field of biomedical engineering, and particularly relates to a bone repair stent for directionally inducing bone tissue differentiation. The functions of the stent are realized through structural design. The method comprises the following steps: constructing a porous unit cell structure; performing analogue simulation of a compression experiment on the porous unit cell structure through a finite element analysis method to obtain a structure matched with the mechanical properties of the human bone; carrying out cell loading on the obtained porous unit cell structure, and judging the osteogenic ability of cell differentiation and bone tissue differentiation through a computational fluid dynamics method; feeding back a calculation fluid dynamics result to finite element analysis, and carrying out structural modification to obtain a bone repair scaffold porous unit cell model which better conforms to directional induction bone tissue differentiation; and preparing the high-precision bone repair stent by using a 3D printing technology. The bone repair stent provided by the invention has better osteogenesis performance and can be used for accurately repairing bone defect parts.

Description

technical field [0001] The invention belongs to the technical field of biomedical engineering, and in particular relates to a bone repair scaffold for directional induction of bone tissue differentiation. Background technique [0002] The growing demand for bone grafts and the limitations of autografts and allografts have prompted new developments in bone tissue engineering. The use of tissue engineering methods and means to repair tissue defects is a new treatment model with broad application prospects and is a hot spot in current medical research. At the same time, the rise of 3D printing technology has broken the limitations of traditional manufacturing processes and has become an ideal process for preparing bone repair scaffolds. [0003] At present, most bone repair scaffolds are mainly researched and designed for material and mechanical properties, and obtain better osteogenic performance from a macro perspective. Bone repair scaffolds usually have the following attr...

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Problems solved by technology

[0004] The bone repair scaffolds in the prior art can meet the requirements of osteogenesis at the macroscopic level, but ignore the key factor that determines the osteogenic performance---the influence of bone cells

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