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Drug screening device based on in-vivo visible light imaging of living animals

A screening device and visible light technology, which is applied in medical science, sensors, diagnostic recording/measurement, etc., can solve the problems of unable to stably measure the luminous value of living animals, long time, large error in measurement results, etc., to improve sensitivity and depth , convenient drug injection, and accurate optical detection results

Inactive Publication Date: 2021-11-05
SUZHOU HEALTH COLLEGE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For example, some antimicrobial drug screening systems can discriminate the efficacy of drugs by detecting the luminescent signals of animals to realize drug screening. However, due to the long time required for exposure and imaging, animals need to be anesthetized during imaging detection, and animals before and after anesthesia The luminescence intensity has a great influence, resulting in large errors in measurement results; and these systems cannot stably determine the luminescence value of the entire living animal and accurately determine the local luminescence value of the animal

Method used

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  • Drug screening device based on in-vivo visible light imaging of living animals
  • Drug screening device based on in-vivo visible light imaging of living animals
  • Drug screening device based on in-vivo visible light imaging of living animals

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Experimental program
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Effect test

Embodiment 1

[0073] Such as Figure 1-3 As shown, a drug screening device based on visible light imaging in living animals in this embodiment includes: an equipment box 1, a dark box 2, an electron multiplying CCD 10 arranged in the equipment box 1, and an excitation light source 24 arranged in the dark box 2 , PMT detector 25, detection lens 26, camera 27, detection lens 26 is connected with electron multiplying CCD10, further, this drug screening device also includes the animal fixing assembly 3 that is rotatably arranged in the dark box 2, is used to drive the animal fixing assembly 3. The first rotary drive mechanism 4 rotating around the Y axis, the temperature control component 5 used to provide air heating for the living animal fixed on the animal fixing component 3, and the three-dimensional displacement mechanism 6 arranged in the dark box 2;

[0074] The field of view of the detection lens 26 covers the entire living animal on the animal fixing assembly 3, so as to perform overal...

Embodiment 2

[0088] refer to Figure 4-10 , the animal fixing assembly 3 is used to fix the living small animal for optical detection, and can realize the rotation of the living small animal, and can be easily disassembled and taken off the small animal to meet the operational requirements in the detection process.

[0089] As a further improvement on the basis of Embodiment 1, in this embodiment, the animal fixation assembly 3 includes a support rod 30 connected to the bottom surface of the top plate 21 of the dark box 2, and a rotating rod 30 rotatably connected to the inner wall of the side plate 20 of the dark box 2. Seat 31 and one end of which is rotatably connected to support rod 30 and the other end of which is drivingly connected to rotating seat 31. The first rotating drive mechanism 4 drives rotating seat 31 to rotate to drive animal fixing frame 32 to rotate; in this embodiment, A flange 313 is fixedly connected to the inner wall of the side plate 20 of the camera obscura 2 , a...

Embodiment 3

[0105] During the detection process, it is necessary to provide a constant temperature environment close to its body temperature for small living animals to maintain their normal physiological state and reduce the influence of temperature factors on the measurement results. In the prior art, live small animals are usually fixed on a constant temperature platform, and heating plates or heating sheets are used to contact the living small animals for heating, which has defects such as uneven heating, mildness, and easy scalding of small animals; in addition, due to The mechanism for fixing small animals in the present invention also needs to provide a rotation function, and the solution in the prior art is also prone to the problem of wire winding due to rotation, so the constant temperature control solution in the prior art is difficult to meet the demand. The present invention provides a constant temperature environment through the structures of the following examples.

[0106]...

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Abstract

The invention discloses a drug screening device based on in-vivo visible light imaging of living animals, which comprises an equipment box, a camera obscura, an electron multiplication CCD arranged in the equipment box, and an exciting light source, a PMT detector, a detection lens and a camera which are arranged in the camera obscura, the medicine screening device further comprises an animal fixing assembly rotationally arranged in the camera obscura, a first rotation driving mechanism used for driving the animal fixing assembly to rotate around the Y axis, a temperature control assembly used for providing air heating for living animals fixed to the animal fixing assembly and a three-dimensional displacement mechanism arranged in the camera obscura. Automatic movement of the probe of the PMT detector is achieved through the three-dimensional displacement mechanism, a fixed living animal can be rotated through the first rotation driving mechanism and the animal fixing assembly, on one hand, optical detection of the whole animal is conveniently achieved, on the other hand, local detection is conveniently conducted through cooperation with the three-dimensional displacement mechanism, the operation in the detection process is simpler, more convenient and quicker.

Description

technical field [0001] The invention relates to the technical field of drug screening, in particular to a drug screening device based on visible light imaging in living animals. Background technique [0002] At present, as the problem of drug resistance becomes more and more serious, the development of new antibacterial drugs and anti-tumor drugs to treat microbial infection-related diseases and tumors has become an urgent problem to be solved. [0003] Drug screening is an important step in the modern drug development process, which is used to select products with certain medicinal effects from a large number of compounds or new compounds through standardized experimental methods. At present, the more commonly used drug screening process is multiple steps such as animal infection or inoculation of transplanted tumors, drug administration, animal sacrifice, organ grinding, and counting of viable bacteria. This method has many disadvantages, such as cumbersome operation and l...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B5/00
CPCA61B5/4848
Inventor 刘松柏
Owner SUZHOU HEALTH COLLEGE
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