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Double-layer film agent for treating oral ulcer and preparation method thereof

An oral ulcer and double-layer film technology, applied in the field of pharmaceutical preparation, can solve the problems of inconvenient use of traditional Chinese medicine ulcer powder, affecting the action time of the drug, and the drug being easily taken away by saliva, so as to promote wound healing and improve the comfort of use. , the effect of enhanced curative effect

Pending Publication Date: 2021-11-09
GUANGDONG MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] The purpose of the present invention is to overcome the problems of inconvenient use of the Chinese patent medicine Kuiyang powder, the powder is applied to the affected area, the medicine is easily taken away by saliva, the action time of the medicine is affected, and the taste of the medicine is not good, and a double-layer membrane for treating oral ulcers is provided. Agents and their preparation methods

Method used

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  • Double-layer film agent for treating oral ulcer and preparation method thereof

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Embodiment Construction

[0017] In order to make the technical problems, technical solutions and advantages to be solved by the present invention clearer, the following will describe in detail in conjunction with specific embodiments.

[0018] A preparation method for a double-layer film for the treatment of oral ulcers, comprising the following steps:

[0019] Preparation of inner membrane glue: Weigh each component according to the ratio of 1-60 parts of chitosan, 1-37 parts of sodium alginate, 1-7 parts of polyvinyl alcohol, and 0.1-1 part of flavoring agent, add water to fully dissolve , to obtain the inner membrane glue by filtration;

[0020] Preparation of drug-loaded intima mucilage: Grind the medicine for treating oral ulcer through a 200-mesh sieve, add the intima mucilage, add glycerol and Tween 80 at the same time, stir well, let it stand for defoaming, and homogenize to obtain Drug intima glue;

[0021] Preparation of waterproof outer membrane glue: add absolute ethanol to the polymer w...

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Abstract

The invention discloses a double-layer film agent for treating oral ulcer and a preparation method thereof. The double-layer film agent for treating oral ulcer is a double-layer one-way drug release film agent, and comprises a porous drug-loaded inner film and a waterproof outer film; the drug-loaded inner film comprises 1-60 parts of chitosan, 1-37 parts of sodium alginate and 1-7 parts of polyvinyl alcohol; the waterproof outer film is prepared by dissolving any one or a combination of more of ethyl cellulose, hydroxyethyl methylacrylate, a methyl methacrylate copolymer and hydroxypropyl methylcellulose acetate succinate in absolute ethyl alcohol, and the concentration is 1%-5%. The double-layer film agent solves the problems that OTC (Over The Count) Chinese patent medicine oral ulcer powder is inconvenient to use, drugs are easy to lose, and the action time of one-time medication is short. In addition, the invention further provides a preparation method of the double-layer film agent for treating oral ulcer.

Description

technical field [0001] The invention relates to the technical field of medicine preparation, in particular to a double-layer film preparation for treating oral ulcers and a preparation method thereof. Background technique [0002] Oral ulcers, also known as "oral sores", are a very common oral mucosal disease. [0003] The oral ulcer patch for the treatment of oral ulcers is not a transparent film as we imagined, it is a tiny patch coated with oral ulcer medicine, which can be directly attached to the oral ulcer, so that the medicine can be fully applied to the oral ulcer place. According to the patient's personal situation, different oral ulcer patches can be selected, and their ingredients are not the same, but generally propolis and anesthetics are added to reduce the pain caused by drug stimulation of oral ulcers, and secondly, it can moisturize the area around oral ulcers of the oral mucosa. Therefore, oral ulcer film is a commonly used method to treat oral ulcers. I...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/70A61K36/704A61K36/315A61K36/195A61K47/36A61K47/32A61K47/38A61K47/14A61P1/02A61K31/045A61K33/06
CPCA61K9/7007A61K9/006A61K36/704A61K36/315A61K36/195A61K31/045A61K33/06A61K47/36A61K47/32A61K47/38A61K47/14A61P1/02A61K2300/00
Inventor 何明华刘坚吴子钊罗辉
Owner GUANGDONG MEDICAL UNIV
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