Supercharge Your Innovation With Domain-Expert AI Agents!

Antimicrobial peptide pHTP-1, use thereof and product containing antimicrobial peptide pHTP-1

An antibacterial peptide, phtp-1 technology, applied in the field of polypeptide drugs, can solve the problems of difficult application in the field of dental caries prevention and control, and inapplicable to the elimination of Streptococcus mutans, and achieves the effect of overcoming drug resistance, novel structure, and small side effects

Active Publication Date: 2021-11-30
HUNAN NORMAL UNIVERSITY
View PDF4 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the physical and chemical parameters such as the charge, hydrophobicity, and helicity of the polypeptide Lycosin-I are not suitable for the disinfecting of Streptococcus mutans, and it is difficult to apply to the field of prevention and treatment of dental caries

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Antimicrobial peptide pHTP-1, use thereof and product containing antimicrobial peptide pHTP-1
  • Antimicrobial peptide pHTP-1, use thereof and product containing antimicrobial peptide pHTP-1
  • Antimicrobial peptide pHTP-1, use thereof and product containing antimicrobial peptide pHTP-1

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0025] An antimicrobial peptide pHTP-1, the amino acid sequence of which is shown in SEQ ID NO:1.

[0026] After successfully designing pHTP-1, the designed peptide samples were prepared by solid-phase peptide chemical synthesis. According to the pH difference, with the positive drug CHX as the control, a series of anti-Streptococcus mutans standard strains, clinically isolated Streptococcus mutans and Streptococcus mutans biofilm experiments were carried out. At the same time, the toxic effect of pHTP-1 on normal oral cells was evaluated. Finally, the mechanism of its acid sensitivity was preliminarily analyzed by characterizing its physicochemical parameters.

[0027] The main methods of the specific design method, preparation method and application research in the preparation of dental caries prevention and treatment drugs are as follows:

[0028] 1. Design of pHTP-1

[0029] 1) Streptococcus mutans dominates the formation of dental caries, and the pH of the formed dental...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
Lc50aaaaaaaaaa
Login to View More

Abstract

The invention discloses an antimicrobial peptide pHTP-1. The antimicrobial peptide pHTP-1 has an amino acid sequence as shown in SEQ ID NO: 1. The antimicrobial peptide pHTP-1 has a novel structure, high specificity, rapid and efficient sterilization and extremely low toxic and side effects, overcomes defects that mainstream anti-dental caries drugs in the market are prone to produce drug resistance, have large damage on oral soft tissues and strong damage to oral flora steady states, has high druggability and a short sequence and is easy to prepare. The invention also discloses use of the antimicrobial peptide pHTP-1 in preparing dental caries-preventing drugs , an oral cavity cleaning preparation and a tooth coating and a product. The antimicrobial peptide pHTP-1 has a good effect on preventing dental caries, a small side effect and low cost.

Description

technical field [0001] The invention belongs to the technical field of polypeptide drugs, and in particular relates to an antibacterial peptide pHTP-1 with a new sequence obtained from template peptide Lycosin-I through optimized design and its use in the preparation of dental caries prevention drugs, toothpaste, mouthwash, and tooth paint. application. Background technique [0002] Dental caries (dental caries) is listed by the World Health Organization as one of the three major non-communicable diseases in the world, which has caused a great burden on the public health system. Streptococcus mutans-dominated biofilm formation is an important factor in the formation of dental caries. The mainstream dental caries prevention products on the market have many defects, such as strong side effects, drug resistance, and tooth staining, which affects the appearance of the teeth. Therefore, the development of safe and efficient dental caries prevention products is imminent, with gre...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): C07K14/435A61K38/17A61P1/02A61K8/64A61Q11/00A61P31/04A61K6/20
CPCC07K14/43518A61P1/02A61K8/64A61Q11/00A61P31/04A61K6/20A61K38/00
Inventor 刘中华张鹏李谨婷梁宋平
Owner HUNAN NORMAL UNIVERSITY
Features
  • R&D
  • Intellectual Property
  • Life Sciences
  • Materials
  • Tech Scout
Why Patsnap Eureka
  • Unparalleled Data Quality
  • Higher Quality Content
  • 60% Fewer Hallucinations
Social media
Patsnap Eureka Blog
Learn More

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2025 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com