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Application of pulsatilla saponin B4 in preparation of medicine for preventing or treating non-alcoholic fatty liver disease

A Pulsatilla saponin, non-alcoholic technology, applied in the direction of drug combinations, pharmaceutical formulations, organic active ingredients, etc., can solve the problems of curative effect and safety that need to be further verified

Pending Publication Date: 2021-12-03
SUZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the efficacy and safety of the above new anti-NASH drugs need to be further verified.

Method used

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  • Application of pulsatilla saponin B4 in preparation of medicine for preventing or treating non-alcoholic fatty liver disease
  • Application of pulsatilla saponin B4 in preparation of medicine for preventing or treating non-alcoholic fatty liver disease
  • Application of pulsatilla saponin B4 in preparation of medicine for preventing or treating non-alcoholic fatty liver disease

Examples

Experimental program
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Effect test

Embodiment

[0030] Experimental Example embodiments rats

[0031] Animal grouping and modeling

[0032] After one week acclimation period, all rats were randomly divided into 2 groups modeling: normal fat diet group and model group. Normal group was given normal diet, normal water, high fat diet model group were given high fat diet, normal water, casting 13 weeks.

[0033] After 13 weeks, the body weight of normal group were randomly divided into two groups, normal control group (N), normal + Pulsatilla saponin B45mg / kg intraperitoneal injection group (N + B4 5mg / kg), the rats were randomly divided fat six groups, i.e. model group (M), positive drug fenofibrate 20 mg / kg orally group, Pulsatilla saponin B4 5mg / kg intraperitoneal injection of the high dose group (B4H ip), Pulsatilla saponin B4 2.5mg / kg intraperitoneal injection of low dose group (B4L ip), Pulsatilla saponin B4 25mg / kg high dose group gavage (B4H ig) and Pulsatilla saponin B4 12.5mg / kg orally low dose group (B4L ig...

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Abstract

The invention discloses an application of pulsatilla saponin B4 in preparation of a medicine for treating non-alcoholic fatty liver disease. As the cell and molecular mechanism of the liver injury of the non-alcoholic fatty liver disease is not very clear yet, and an effective drug treatment method for the non-alcoholic fatty liver disease is lacked, so that positive exploration of safe and effective drug treatment is a current research hotspot. The curative effect and the safety of the existing medicine need to be further improved or verified. The invention discloses a novel medicine for treating non-alcoholic fatty liver disease, the active ingredient is pulsatilla saponin B4, experiments prove that the pulsatilla saponin B4 can effectively reduce lipid accumulation of rat liver caused by high fat diet, the curative effect is equivalent to that of a positive control medicine, the side effect of hepatotoxicity caused by fenofibrate can be avoided, and therefore, the pulsatilla saponin B4 can be used for preventing and treating non-alcoholic fatty liver disease (NAFLD).

Description

Technical field [0001] The present invention belongs to the pharmaceutical technology, particularly relates to a pharmaceutical preparation Pulsatilla saponin B4 in the treatment of non-alcoholic fatty liver in. Background technique [0002] Non-alcoholic fatty liver disease (NAFLD) is a metabolic stress-induced liver injury is closely associated with insulin resistance and genetic susceptibility, the pathological changes and alcoholic liver disease (ALD) is similar, but patients with no history of excessive alcohol consumption, with the course of progress in turn divided into nonalcoholic fatty liver (NAFL), non-alcoholic steatohepatitis (NASH), cirrhosis and hepatocellular carcinoma (HCC). [0003] Recent studies showed that metabolic syndrome (MetS) is NAFLD, NASH occurrence of the strongest risk factors for metabolic syndrome including waist circumference (such as obesity), high blood sugar, high cholesterol, high blood pressure. The association between MetS and NAFLD may be ...

Claims

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Application Information

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IPC IPC(8): A61K31/704A61P1/16A61P3/06
CPCA61K31/704A61P1/16A61P3/06
Inventor 刘艳丽许琼明肖明粤
Owner SUZHOU UNIV
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