Microcapsule decoction tables for embedding components for preventing and improving Alzheimer's disease and dementia and preparation method of microcapsule decoction tables

A technology for Alzheimer's disease and dementia, applied in the field of drug preparation, can solve the problem of low therapeutic effect, achieve good sustained release effect, increase stability, prevent and improve the effect of Alzheimer's disease and dementia

Pending Publication Date: 2021-12-03
QUFU NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Treatment for this condition is curren...

Method used

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  • Microcapsule decoction tables for embedding components for preventing and improving Alzheimer's disease and dementia and preparation method of microcapsule decoction tables
  • Microcapsule decoction tables for embedding components for preventing and improving Alzheimer's disease and dementia and preparation method of microcapsule decoction tables
  • Microcapsule decoction tables for embedding components for preventing and improving Alzheimer's disease and dementia and preparation method of microcapsule decoction tables

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] (1) Mix various Chinese medicine ingredients according to the proportion and grind them into powder to obtain the mixed powder, and the proportion is as shown in Table 1;

[0029] Table 1

[0030]

[0031] (2) Due to the poor solubility of some Chinese medicines, the mixed powder of Chinese medicines was dissolved in absolute ethanol to obtain a Chinese medicine solution with a concentration of 0.5 mg / mL;

[0032] (3) dissolving chitosan in 1% acetic acid solution to obtain a chitosan solution with a concentration of 2%, then adding the mixed Chinese medicine solution to the chitosan solution, stirring, and 150W ultrasonic 10min;

[0033] (4) adding toluene to the solution in step (3) according to the volume ratio is 1:1 to carry out chemical cross-linking, carry out ultrasonication, centrifugation, obtain the chitosan microspheres of wrapping traditional Chinese medicine after resuspending in ultrapure water;

[0034] (5) adding poly-gamma-glutamic acid to water to...

Embodiment 2

[0037] (1) Mix various Chinese medicine ingredients according to the proportion and grind them into powder to obtain the mixed powder, the proportion is as in Example 1;

[0038] (2) Due to the poor solubility of some Chinese medicines, the mixed powder of Chinese medicines was dissolved in absolute ethanol to obtain a Chinese medicine solution with a concentration of 0.5 mg / mL;

[0039] (3) dissolving chitosan in 1% acetic acid solution to obtain a chitosan solution with a concentration of 3%, then adding the mixed Chinese medicine solution to the chitosan acetic acid solution, stirring, and 150W ultrasonic 10min;

[0040] (4) adding toluene to the solution in step (3) according to the volume ratio is 1:1 to carry out chemical cross-linking, carry out ultrasonication, centrifugation, obtain the chitosan microspheres of wrapping traditional Chinese medicine after resuspending in ultrapure water;

[0041] (5) adding poly-gamma-glutamic acid to water to configure a poly-gamma-gl...

Embodiment 3

[0044] (1) Mix various Chinese medicine ingredients according to the proportion and grind them into powder to obtain the mixed powder, the proportion is as in Example 1;

[0045] (2) Due to the poor solubility of some Chinese medicines, the mixed powder of Chinese medicines was dissolved in absolute ethanol to obtain a Chinese medicine solution with a concentration of 1 mg / mL;

[0046](3) dissolving chitosan in 1% acetic acid solution to obtain a chitosan solution with a concentration of 3%, then adding the mixed Chinese medicine solution to the chitosan solution, stirring, and 150W ultrasonic 10min;

[0047] (4) adding toluene to the solution in step (3) according to the volume ratio is 1:1 to carry out chemical cross-linking, carry out ultrasonication, centrifugation, obtain the chitosan microspheres of wrapping traditional Chinese medicine after resuspending in ultrapure water;

[0048] (5) adding poly-gamma-glutamic acid to water to configure a poly-gamma-glutamic acid sol...

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Abstract

The invention belongs to the technical field of medicine preparation, and particularly relates to microcapsule decoction tables for embedding components for preventing and improving Alzheimer's disease and dementia and a preparation method of the microcapsule decoction tables. The microcapsule decoction tables are prepared by taking poly gamma-glutamic acid/chitosan as a carrier and loading a traditional Chinese medicine extract, wherein the traditional Chinese medicine extract comprises the following raw materials: radix ginseng, radix salviae miltiorrhizae roots, herba epimedii, rhizoma curcumae longae dried rhizomes, coffee beans, broccoli buds, acorn and bolete. The gamma-PGA-CS micro-capsule decoction tables prepared by the preparation method disclosed by the invention have a good slow-release effect on embedded traditional Chinese medicine components, and the preparation method is simple and low in raw material cost. The microcapsule decoction tables provided by the invention are high in medicine loading capacity, capable of embedding multiple medicines at the same time, high in bioavailability and capable of reducing side effects to the maximum extent so as to achieve the effects of preventing and improving Alzheimer's disease and dementia and the like.

Description

technical field [0001] The invention belongs to the technical field of medicine preparation and relates to a novel composite carrier material, in particular to a microcapsule decoction piece capable of embedding components for preventing and improving Alzheimer's disease and dementia and a preparation method thereof. Background technique [0002] In today's life, with the advent of the aging era, Alzheimer's disease has become a burden worldwide. Alzheimer's disease (AD) is not equal to dementia, or it is just one of its branches. AD is an insidious progressive neurodegenerative disease. Clinically, it is characterized by comprehensive dementia such as memory impairment, aphasia, apraxia, agnosia, impairment of visuospatial skills, executive dysfunction, and personality and behavior changes. The etiology is still unknown. It may be due to the fact that when certain proteins accumulate too much in and out of brain cells, it is difficult for brain cells to maintain healthy a...

Claims

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Application Information

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IPC IPC(8): A61K47/34A61K47/36A61K36/9066A61K9/00A61K9/52A61P25/28
CPCA61K47/34A61K47/36A61K36/258A61K36/537A61K36/296A61K36/9066A61K36/74A61K36/31A61K36/49A61K36/07A61K9/0095A61K9/5031A61K9/5036A61P25/28A61K2300/00
Inventor 杨革梁兆仪车程川刘金锋巩志金
Owner QUFU NORMAL UNIV
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