Pharmaceutical composition and preparation method thereof
A composition and drug technology, applied in the field of medicine, can solve the problem of failing to find and prevent glaucoma, and achieve the effects of good batch-to-batch viscosity uniformity, good stability, and good bacteriostatic effect.
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Embodiment 1
[0109] The consumption of each raw material of the dorzolamide hydrochloride eye drops of the present embodiment is as follows:
[0110] Dorzolamide hydrochloride 111.3g, sodium citrate dihydrate 14.7g, mannitol 80g, hydroxypropyl cellulose 16.67g, povidone 6.67g, propylene glycol alginate 1.66g, benzalkonium chloride 0.025g, after preparation Add water for injection to make up to 5000mL.
[0111] The preparation method of the dorzolamide hydrochloride eye drops of the present embodiment may further comprise the steps:
[0112] 1) Take water for injection with a total volume of 30%, heat it to keep the water temperature at 80°C, add 16.67g hydroxypropyl cellulose and 6.67g povidone under stirring, and continue stirring for 30min; Sodium citrate hydrate, 80g mannitol, 0.025g benzalkonium chloride, keep the water temperature at 60°C, stir for 20-30min, under stirring, sterilize at 121°C for 15min, cool the liquid to 30°C, then filter and collect filtrate;
[0113] 2) Take wat...
Embodiment 2
[0119] The consumption of each raw material of the dorzolamide hydrochloride eye drops of the present embodiment is as follows:
[0120] Dorzolamide hydrochloride 111.3g, sodium citrate dihydrate 14.7g, mannitol 80g, hydroxypropyl cellulose 12.5g, povidone 10.7g, propylene glycol alginate 1.78g, benzalkonium chloride 0.005g, after preparation Add water for injection to make up to 5000mL.
[0121] The preparation method of the dorzolamide hydrochloride eye drops of the present embodiment may further comprise the steps:
[0122]1) Take water for injection with a total volume of 30%, heat it to keep the water temperature at 80°C, add 12.5g of hydroxypropyl cellulose, 10.7g of povidone, and 0.89g of propylene glycol alginate under stirring, continue stirring for 30min, and then In the state, add 14.7g sodium citrate dihydrate, 80g mannitol, 0.005g benzalkonium chloride, keep the water temperature at 60°C, stir for 20-30min, and sterilize at 121°C for 15min while stirring, and coo...
Embodiment 3
[0129] The consumption of each raw material of the dorzolamide hydrochloride eye drops of the present embodiment is as follows:
[0130] Dorzolamide hydrochloride 111.3g, sodium citrate dihydrate 14.7g, mannitol 80g, hydroxypropyl cellulose 21.44g, povidone 1.78g, propylene glycol alginate 1.78g, benzalkonium chloride 0.05g, after preparation Add water for injection to make up to 5000mL.
[0131] The preparation method of the dorzolamide hydrochloride eye drops of the present embodiment may further comprise the steps:
[0132] 1) Take water for injection with a total volume of 30%, heat it to keep the water temperature at 80°C, add 21.44g hydroxypropyl cellulose, 1.78g povidone, and 0.78g propylene glycol alginate under stirring, and continue stirring for 30 minutes; In the state, add 14.7g sodium citrate dihydrate, 80g mannitol, 0.05g benzalkonium chloride, keep the water temperature at 60°C, stir for 20-30min, sterilize at 121°C for 15min, cool the liquid to 30°C, and then ...
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