A method for preparing patch-like anisotropic spherical micelles based on non-covalent post-modification of small molecules

Abstract

The invention belongs to the field of polymer nanomaterials, and specifically discloses a method for preparing patch-shaped anisotropic spherical micelles based on non-covalent post-modification of small molecules. Diblock copolymers self-assemble in solution to form core-shell structured spherical micelles. A small aromatic molecule containing a single amino group is added to the micellar solution, and the micelle The surface is post-modified, and at the same time, small molecules are induced to migrate and phase-separate inside the micelle shell through the π-π stacking effect between the modified small molecules, forming patchy anisotropic spherical micelles. Starting from only one diblock copolymer, the method can realize the preparation of patchy micelles with controllable number, size and distribution of patches through simple mixing of small molecules and polymer micelle solution. The universality is strong, the system is simple and stable, the assembly conditions are mild, and the energy consumption is low. The obtained patchy micelles have potential application value in the fields of chemistry, biology, medicine, etc., and are easy to promote.

Description

technical field [0001] The invention belongs to the field of macromolecular nanomaterials, in particular to a method for preparing patch-shaped anisotropic spherical micelles based on non-covalent post-modification of small molecules. Background technique [0002] Patch-like micelles are a kind of multi-chambered micelles, and patch-like micelles with different structures show great application value in the fields of multiple drug controlled release, heterogeneous catalytic reaction carriers, and the construction of integrated reactors. Since the concept of multi-chambered micelles was proposed by Ringsdorf et al. in the mid-1990s, patch-like micelles with various structural parameters have been prepared by self-assembly of block copolymers in solution. [0003] Crystallization-induced self-assembly or phase separation of heteroshell micellar shells are typical methods to prepare patch-like micelles. However, in crystallization-induced self-assembly, the chemical compositio...

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Problems solved by technology

However, in crystallization-induced self-assembly, the chemical composition and structural parameters of the polymer are high, and it is difficult to promote on a large scale; the preparation of heteroshell micelles relies on triblock copolymers with definite structural parameters, and the patchy micelles The structural parameters are determined by the volume ratio of each block in the tri-block copolymer. Although it is no longer difficult to synthesize multi-block copolymers with the development of controllable polymerization technology, it is not easy to precisely control the volume ratio of each block. And many multi-block copolymers that have been commercialized are often more expensive

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