Coordination compound as well as preparation method and application thereof

Abstract

The invention belongs to the technical field of medical materials, and discloses a coordination compound as well as a preparation method and application thereof. The coordination compound is prepared from anthocyanin and metal ions; the anthocyanin has very high oxidation resistance and good antibacterial performance, and phenolic hydroxyl groups in the anthocyanin structure can be chelated with the metal ions, and can also chemically react with amino, sulfydryl, hydroxyl or carboxyl and the like on the surface of biological tissue under a mild condition to generate covalent bonds; and wound skin tissue is chemically anchored, and strong adhesive force is provided by forming the covalent bonds, so that wound adhesion and tissue repair in a wet state are realized, namely, a metal-polyphenol coordination polymerization principle is adopted for preparing the anthocyanin-metal ion coordination compound. According to the invention, a stent material is prepared by using an electrostatic spinning technology, a multifunctional electrospun fiber dressing capable of realizing in-situ monitoring and treating of bacterial infection is prepared by loading the anthocyanin-metal ion coordination compound, and the application prospect is wide.

Description

technical field [0001] The invention belongs to the technical field of medical materials, and in particular relates to a coordination compound and its preparation method and application. Background technique [0002] The skin is the body's natural barrier, protecting the body's internal tissues and organs from the outside world, while sensing and regulating body temperature. When the skin is subjected to some inevitable physical, chemical and biological damages such as burns, surgical wounds, war wounds, bacterial infection and foot ulcers, etc., it will cause skin wounds, and once the skin wounds are formed, the human body loses the first natural protection The barrier, bacteria and other pathogenic microorganisms will colonize, multiply and infiltrate the wound surface, often causing wound infection. Wound infection often leads to delayed wound healing. Severe wound infection may cause immune dysfunction, systemic infection, sepsis, septicemia, or cause chronic inflammati...

AI Technical Summary

Problems solved by technology

Moreover, excessive ROS can lead to dysfunction of related cells such as endogenous stem cells, endothelial cells, and macrophages, inhibit angiogenesis, and hinder wound tissue healing.

However, the current wound dressings cover the wound surface, so it is impossible to visually see the healing of the wound surface, and the antibacterial performance is limited, so it cannot meet the actual needs

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