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Method for realizing sol-gel-sol autonomous transformation based on competitive reaction

A competitive reaction and sol technology, applied in the field of medical polymer materials, can solve the problems of high cost, unfriendliness, high price, etc., and achieve the effects of low cost, efficient reaction and good water solubility

Active Publication Date: 2021-12-21
山东大学深圳研究院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Inspired by the energy dissipation self-assembly system in nature, the researchers first proposed the concept of transient hydrogel in 2010 by Jan H. van Esch. In this system, the researchers selected non-biologically active chemical reagents to realize the system from sol From gel to sol, in order to further simulate the life system, the researchers introduced the biocatalytic reaction network into the hydrogel system, mainly the introduction of various enzymatic reactions, including chymotrypsin, esterase and urease, etc. However, in the research work reported so far, the price of these enzymes is often relatively expensive, which will lead to high costs, or the introduction of urea, a substance unfriendly to living organisms, in the design of the system is not really suitable for tissue engineering, Biomedical field

Method used

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  • Method for realizing sol-gel-sol autonomous transformation based on competitive reaction
  • Method for realizing sol-gel-sol autonomous transformation based on competitive reaction

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] In Example 1, the preparation method of 200mg / mL F-127 solution: In an ice bath environment, add 60mL of deionized water to 20g of F-127, stir evenly, and set the volume to 100mL, store in the refrigerator for later use.

Embodiment 2

[0037] In Example 2, the preparation method of 300mg / mL F-68 solution: In an ice bath environment, add 60mL deionized water to 30g F-68, stir evenly, and set the volume to 100mL, store in the refrigerator for later use.

[0038] Example 1

[0039] A method for realizing sol-gel-sol autonomous transformation based on a competitive reaction, the method is carried out based on a competitive reaction system,

[0040] Configure the competing response system:

[0041] Add 1 mL of deionized water to the centrifuge tube at room temperature, add 100 mg of α-amylase to dissolve completely, add 1 mL of 200 mg / mL F-127 solution, mix well at room temperature, then add 160 mg of α-cyclodextrin to the centrifuge tube and mix well .

[0042] After the above components are mixed evenly, F-127 and cyclodextrin form a gel through supramolecular interaction in about 20 minutes. At the same time, α-amylase in the system is added to hydrolyze the cyclodextrin so that the gel gradually disintegrat...

Embodiment 3

[0055] A method for realizing sol-gel-sol autonomous transformation based on a competitive reaction, the method is carried out based on a competitive reaction system,

[0056] Configure the competing response system:

[0057] Add 1 mL of deionized water to the centrifuge tube at room temperature, add 160 mg of amylase to dissolve completely, add 1 mL of 360 mg / mL F-127 solution, mix well at room temperature, then add 120 mg α-cyclodextrin to the centrifuge tube and mix well.

[0058] After the above components are mixed evenly, F-127 and α-cyclodextrin form a gel through supramolecular interaction in about 20 minutes. At the same time, amylase in the system is added to hydrolyze the cyclodextrin to make the gel gradually disintegrate, and finally, F- 127 mixed with glucose and amylase to complete a complete autonomous transformation process from sol to gel and then to sol.

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Abstract

The invention relates to a method for realizing sol-gel-sol autonomous transformation based on competitive reaction, the method is carried out based on a competitive reaction system, the competitive reaction system comprises biological enzyme and biocompatible materials at the same time, the biocompatible materials mutually form supramolecular interaction to form gel, the gel is disintegrated through enzymatic reaction, and gel forming and gel disintegration are formed in the same system and compete with each other, so that continuous autonomous transformation of the system from sol to gel to sol is realized. According to the conversion method, external stimulation is not needed, a switch for autonomously carrying out sol-gel-sol conversion is arranged in a competitive reaction system, a soft material is endowed with autonomy or self-adaptability, the method is widely applied to the field of biological medicine, and the method is low in cost, non-toxic and harmless.

Description

technical field [0001] The invention relates to a method for realizing sol-gel-sol autonomous transformation based on competitive reactions, and belongs to the field of medical polymer materials. Background technique [0002] Hydrogels have been extensively studied as scaffold materials in tissue engineering. Since the three-dimensional network of the hydrogel is filled with a large amount of water, the material as a whole has a fluid property, which is very similar to a body tissue filled with a large amount of water, which is conducive to the transmission of nutrients and the discharge of cell metabolites, making the hydrogel Has good biocompatibility. Among them, the injectable hydrogel is in a flowing solution state before gelation, and can easily fill the entire irregular defect site. The surgical trauma is very small and easy to operate, and it is most suitable for the construction of soft tissue organs with low mechanical strength. [0003] Supramolecular hydrogel m...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J13/00C12P19/02C12P19/14C12P19/20C12P19/22
CPCB01J13/0004B01J13/0026B01J13/0034B01J13/0065C12P19/22C12P19/14C12P19/20C12P19/02
Inventor 王旭逯浩月
Owner 山东大学深圳研究院
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