Special-appearance gel with whitening effect and preparation method of special-appearance gel
A special appearance technology, applied in medical preparations containing active ingredients, skin care preparations, pharmaceutical formulations, etc., can solve the problems of temperature sensitivity, unable to maintain aurora appearance for a long time, unable to achieve deep whitening, and not suitable for fragile skin, etc. To achieve the effect of improving moisturizing effect, reducing ROS content and enhancing skin penetration ability
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[0040] Prepare embodiment according to following table 1, carry out following test, preparation method is as follows:
[0041] (1) Add deionized water, moisturizer, and skin conditioning agent into the manufacturing pot and stir evenly, heat up to 70-75°C, homogenize at 3000 rpm and stir for three minutes, keep warm for later use;
[0042] (2) Reduce the temperature of the manufacturing pot to 60-65°C, add nicotinamide, homogenize at 3000 rpm, and stir evenly;
[0043] (3) Put thickener into the manufacturing pot and stir evenly;
[0044] (4) Cool the manufacturing pot to 40-45°C, put in antibacterial agent, stir evenly, cool down to 30-35°C, put in hollyhock flower extract, Norway spruce leaf extract, nicotinamide, and cosmetic accessories and stir evenly;
[0045] (5) Put the emollient into the homogeneous material body in step (4), and stir evenly to obtain a special-looking jelly with whitening effect.
[0046] The preparation method of the hollyhock flower extract used ...
experiment example 1
[0066] Experimental Example 1: Stability Test
[0067] Put test samples Examples 1-10, Comparative Examples 1-4 and a commercially available jelly product with an aurora appearance at different temperatures (-18, -7, 4, 25, 37, 45, 50°C, light) Store in a constant temperature box for one month. When the sample returns to room temperature, observe whether there will be changes in stability factors such as appearance and fragrance, and judge the stability of the gel. The degree of change is scored from 0 to 3 points, 0 is no obvious change in color, appearance and smell, 1 is acceptable slight change (such as slight color change or taste change), 2 is unacceptable obvious change (such as special appearance of Aurora jelly 3 means serious changes (such as the disappearance of the aurora jelly with special appearance, and the layering of the material body). The stability observation results are shown in Table 4.
[0068] Table 4: Stability of Examples 1-11, Comparative Examples 1...
experiment example 2
[0072] Experimental example 2: Moisture improvement of stratum corneum
[0073] Select the subject's forearm curved side skin 2*2cm 2 Test area, use embodiment 1-10, comparative example 1-4 1ml after artificially inducing damaged skin barrier (20%wt sodium lauryl sulfate patch ten minutes, carry out three times) to be applied to test site, use Cornemerter CM825 (CK, Germany) measured the moisture content of the stratum corneum of the skin before application, after artificially induced barrier damage, and after application of the product.
[0074] The increase or decrease rate of the moisture content of the cuticle = [(the moisture content of the cuticle during the test - the moisture content of the cuticle before use) / the moisture content of the cuticle before use]*100%
[0075] The test results are shown in Table 5.
[0076] table 5
[0077]
[0078] The experimental results show:
[0079] (1) Comparing Examples 1-10 and Comparative Examples 1-4, when the product conta...
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