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Antiviral pharmaceutical composition

A composition and antiviral technology, applied in the directions of drug combinations, antiviral agents, pharmaceutical formulations, etc., can solve the problems of limited application in the field of biomedicine, and the effect is not obvious, and achieve great clinical application value and social benefits, and the effect is remarkable. , the preparation method is simple

Pending Publication Date: 2021-12-24
冒昊天
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, it has been reported in the literature that medicinal and edible plants such as Fritillaria, Imperatae, and Astragalus have multiple functions such as antibacterial, antitumor, and antiviral, but their effects are not obvious when used alone, which limits their use in the field of biomedicine. Applications

Method used

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  • Antiviral pharmaceutical composition
  • Antiviral pharmaceutical composition
  • Antiviral pharmaceutical composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Embodiment 1 Preparation of the pharmaceutical composition of the present invention

[0018] Chuan Fritillaria, Rhizoma Imperatae, Green Fruit, Chicory, Wild Chrysanthemum, Astragalus, Dandelion, and Licorice are all commercially available.

[0019] In a 1000ml flask, add 6g fritillaria, 5g Imperata rhizome, 5g green fruit, 5g chicory, 4g wild chrysanthemum, 3g astragalus, 3g dandelion, 2g licorice, mix with 500ml 10%-90% alcohol aqueous solution, stir well to make it even , heated to reflux for 24 hours, then cooled to 2°C, left to stand for 24 hours, filtered to remove insoluble matter, and the filtrate was concentrated to obtain 10.5 g of syrup. Add 80ml of distilled water to dissolve, cool to 5°C, let stand for 24 hours, filter out the insoluble matter, add distilled water to make the volume to 100ml, and obtain the pharmaceutical composition.

Embodiment 2

[0020] Embodiment 2 Preparation of the pharmaceutical composition of the present invention

[0021] Chuan Fritillaria, Rhizoma Imperatae, Green Fruit, Chicory, Wild Chrysanthemum, Astragalus, Dandelion, and Licorice are all commercially available.

[0022] In a 1000ml flask, add 6g Fritillaria fritillaria, 6g Rhizoma Imperatae, 8g green fruit, 2g chicory, 3g wild chrysanthemum, 3g astragalus, 2g dandelion, mix with 500ml 10%-90% alcohol aqueous solution, stir well to make it even, heat to reflux After 24 hours, it was cooled to 2°C, and after standing for 24 hours, the insoluble matter was removed by filtration, and the filtrate was concentrated to obtain 10.8 g of syrup. Add 80ml of distilled water to dissolve, cool to 5°C, let stand for 24 hours, filter out the insoluble matter, add distilled water to make the volume to 100ml, and obtain the pharmaceutical composition.

Embodiment 3

[0023] The preparation of embodiment 3 pharmaceutical composition of the present invention

[0024] Chuan Fritillaria, Rhizoma Imperatae, Green Fruit, Chicory, Wild Chrysanthemum, Astragalus, Dandelion, and Licorice are all commercially available.

[0025] In a 1000ml flask, add 5g of Fritillaria fritillaria, 3g of Imperata rhizome, 4g of green fruit, 6g of chicory, 2g of wild chrysanthemum, 4g of astragalus, 1g of dandelion, mix with 500ml of 10%-90% alcohol aqueous solution, stir well to make it uniform, and heat to reflux After 24 hours, it was cooled to 2°C, and after standing for 24 hours, the insoluble matter was removed by filtration, and the filtrate was concentrated to obtain 11.0 g of syrup. Add 80ml of distilled water to dissolve, cool to 5°C, let stand for 24 hours, filter out the insoluble matter, add distilled water to make the volume to 100ml, and obtain the pharmaceutical composition.

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Abstract

The invention discloses an antiviral pharmaceutical composition, which is prepared from the following ingredients in percentage by weight: 2 to 10 percent of bulbus fritillariae cirrhosae, 2 to 10 percent of rhizoma imperatae, 2 to 8 percent of fructus canarii, 2 to 8 percent of herba cichorii, 1 to 6 percent of flos chrysanthemi indici, 1 to 5 percent of radix astragali seu hedysari, 1 to 5 percent of herba taraxaci and 1 to 3 percent of radix glycyrrhizae. Results of antiviral experiments of the pharmaceutical composition show that the pharmaceutical composition has significant antiviral activity. The pharmaceutical composition disclosed by the invention has a good antiviral effect, so that the pharmaceutical composition can be used for treating viral pneumonia such as novel coronavirus pneumonia (SARS-CoV-2) and influenza A virus H3N2; and the preparation method is simple, is suitable for industrial production, and has great clinical application value and social benefit.

Description

technical field [0001] The present invention relates to a pharmaceutical composition, in particular to an antiviral pharmaceutical composition, in particular to the treatment of viral pneumonia such as novel coronavirus pneumonia (SARS-CoV-2) and influenza such as H3N2 influenza A virus and the like. Background technique [0002] Novel coronavirus pneumonia (SARS-CoV-2) is a viral pneumonia that broke out in 2019. Viral pneumonia is caused by viral infection of the upper respiratory tract, which spreads downward and causes inflammation of lung tissue. The disease mostly occurs in winter and spring, and can be outbreaks or sporadic epidemics. Common viruses that cause adults include "SARS-CoV-2" new coronavirus, influenza A and B, adenovirus, parainfluenza virus, respiratory syncytial virus, coronavirus, SARS coronavirus and highly pathogenic avian influenza virus, etc. . Viral pneumonia can occur in immunocompetent or suppressed children and adults, but bone marrow or org...

Claims

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Application Information

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IPC IPC(8): A61K36/899A61P11/00A61P31/14A61P31/16
CPCA61K36/8966A61K36/899A61K36/32A61K36/28A61K36/287A61K36/481A61K36/288A61K36/484A61P31/14A61P31/16A61P11/00A61K2300/00
Inventor 不公告发明人
Owner 冒昊天