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Polyvinyl alcohol sponge with ordered porous structure prepared on basis of 3D printing template and application thereof

A technology of polyvinyl alcohol sponge and porous structure, applied in medical science, absorbent pads, pharmaceutical formulations, etc., to achieve excellent blood compatibility, excellent biocompatibility, eliminate biological safety and side effects

Pending Publication Date: 2021-12-24
WENZHOU INST UNIV OF CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these hemostatic agents have certain limitations in the face of incompressible penetrating injuries

Method used

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  • Polyvinyl alcohol sponge with ordered porous structure prepared on basis of 3D printing template and application thereof
  • Polyvinyl alcohol sponge with ordered porous structure prepared on basis of 3D printing template and application thereof
  • Polyvinyl alcohol sponge with ordered porous structure prepared on basis of 3D printing template and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] A polyvinyl alcohol sponge with an ordered porous structure prepared based on a 3D printing template is prepared by the following steps:

[0044] (1) Obtain a 3D printed sacrificial template by photolithography. Use liquid photosensitive resin as 3D printing material. First, a 3D hollow cube was designed on the SolidWorks 2019 software, and 49 cone structures with a taper of 0 were set inside. Import it into the printing software CHITUBOX as an STL format, and set the printing parameters. Finally, import the program into the 3D printer for printing.

[0045] (2) Dissolve polyvinyl alcohol in ultrapure water, prepare a polyvinyl alcohol suspension with a mass concentration of 5%-15%, and raise the temperature to 95°C. Add 1%-5% sodium alginate to it and cool to room temperature.

[0046] (3) Add 0.1%-0.5% foaming agent to (2), stir vigorously at 1500rmp for foaming, then add 0.25%-5% HCl (1mol / l).

[0047] (4) Add 0.025%-0.05% cross-linking agent to (2) and cross-...

Embodiment 2

[0050] (1) Obtain a 3D printed sacrificial template by photolithography. Use liquid photosensitive resin as 3D printing material. First, a 3D hollow cube was designed on the SolidWorks 2019 software, and 49 cone structures with a taper of 1 / 2 were set inside. Import it into the printing software CHITUBOX as an STL format, and set the printing parameters. Finally, import the program into the 3D printer for printing.

[0051] (2) Dissolve polyvinyl alcohol in ultrapure water, prepare a polyvinyl alcohol suspension with a mass concentration of 5%-15%, and raise the temperature to 95°C. Add 1%-5% sodium alginate to it and cool to room temperature.

[0052] (3) Add 0.1%-0.5% foaming agent to (2), stir vigorously at 1500rmp for foaming, then add 0.25%-5% HCl (1mol / l).

[0053] (4) Add 0.025%-0.05% cross-linking agent to (2) and cross-link at 1000rmp for half an hour, and pour the cross-linked solution into the mold prepared in (1) and place it at 70° C oven for 4 hours to mak...

Embodiment 3

[0056] (1) Obtain a 3D printed sacrificial template by photolithography. Use liquid photosensitive resin as 3D printing material. First, a 3D hollow cube was designed on the SolidWorks 2019 software, and 49 cone structures with a taper of 2 / 3 were set inside. Import it into the printing software CHITUBOX as an STL format, and set the printing parameters. Finally, import the program into the 3D printer for printing.

[0057] (2) Dissolve polyvinyl alcohol in ultrapure water, prepare a polyvinyl alcohol suspension with a mass concentration of 5%-15%, and raise the temperature to 95°C. Add 1%-5% sodium alginate to it and cool to room temperature.

[0058] (3) Add 0.1%-0.5% foaming agent to (2), stir vigorously at 1500rmp for foaming, then add 0.25%-5% HCl (1mol / l).

[0059] (4) Add 0.025%-0.05% cross-linking agent to (2) and cross-link at 1000rmp for half an hour, and pour the cross-linked solution into the mold prepared in (1) and place it at 70° C oven for 4 hours to mak...

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Abstract

The invention provides a polyvinyl alcohol sponge with an ordered porous structure prepared on the basis of a 3D printing template and an application thereof. When the sponge with ordered micro-channels makes contact with blood, the sponge can rapidly guide and absorb the blood, and a large number of regularly-arranged red blood cells are gathered in the micro-porous structure at the bottom of the sponge. The sponge prepared by combining structured ordered micro-channels and disordered holes greatly shortens the blood coagulation time and improves the hemostasis efficiency. The used raw materials have excellent biocompatibility, and potential biological safety and side effects are eliminated in the clinical use process. The used raw materials have excellent blood compatibility, do not cause hemolytic reaction and do not affect endogenous and exogenous blood coagulation pathways.

Description

technical field [0001] The invention relates to the technical field of hemostatic materials, in particular to a polyvinyl alcohol sponge with an ordered porous structure prepared based on a 3D printing template and its application. Background technique [0002] Accidental trauma is an inevitable problem, and physiological hemostasis can alleviate the damage caused by accidental trauma to a certain extent. First, small blood vessels near the damaged vessel constrict, reducing local blood flow. Then locally damaged red blood cells release ADP and thrombin generated during local coagulation can activate platelets to release endogenous ADP and TXA2, thereby activating and recruiting more platelets, forming a platelet hemostatic plug to block the wound, and achieving preliminary hemostasis. Finally, coagulation factors are activated in a certain order to generate thrombin, which finally converts soluble fibrinogen in plasma into insoluble fibrin, and interweaves them into a netw...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08L29/04C08L5/04C08J9/04C08J9/28A61L15/24A61L15/42A61L15/44
CPCC08J9/04C08J9/0061C08J9/28A61L15/425A61L15/24A61L15/42A61L15/44C08J2329/04C08J2405/04C08J2201/0484A61L2400/04A61L2300/418C08L29/04
Inventor 石长灿李鹏鹏杨啸曹丽娜桑峰陈叶祎季志孝潘璐琪
Owner WENZHOU INST UNIV OF CHINESE ACAD OF SCI
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