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Charge-guided micro/nano adhesive hydrogel as well as preparation method and application thereof

A technology of hydrogel and hydrogel microspheres, which is applied in the direction of nanotechnology, nanotechnology, nanomedicine, etc., can solve the problems of inability to penetrate cartilage, prolong half-life, and inability to combine with cartilage, so as to improve the utilization rate of drugs, Efficient delivery and improved curative effect

Pending Publication Date: 2022-01-07
上海市伤骨科研究所
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Appropriately sized hydrogel microspheres can minimize clearance by blood vessels or lymphatic vessels, thereby prolonging the half-life; however, micron-sized particle carriers can neither penetrate nor bind to cartilage, which is suspended in synovial fluid, Continuously release drugs into the joint cavity, which is not conducive to the utilization of drugs

Method used

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  • Charge-guided micro/nano adhesive hydrogel as well as preparation method and application thereof
  • Charge-guided micro/nano adhesive hydrogel as well as preparation method and application thereof
  • Charge-guided micro/nano adhesive hydrogel as well as preparation method and application thereof

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Embodiment

[0033] In this example, the overall process of the synthesis of positively charged liposomes and the preparation of PDA@Lipo@HAMA microspheres is as follows: figure 1 shown.

[0034] Raw materials: 4-Hydroxymethylphenylboronic acid pinacol ester (PBAP), formamide, dextran and 4-dimethylaminopyridine (DMAP) from Shanghai McLean Biochemical Technology Co., Ltd.; 1,1'-carbonyldiimidazole (CDI), GA (gallic acid), cholesterol, lecithin (from egg yolk) were from Shenggong Bioengineering (Shanghai) Co., Ltd. Stearylamine (SA) was obtained from Tixiai (Shanghai) Chemical Industry Development Co., Ltd.

[0035] 1.1 Preparation and physical properties of liposomes

[0036] In the present embodiment, the improved film dispersion method is adopted to prepare liposomes, and the method is as follows:

[0037] Synthesis of amphiphilic block copolymer (PHB-dextran): PBAP (5.85 g, 25 mmol) and CDI (8.11 g, 50 mmol) were dissolved in dry dichloromethane (30 mL). After 30 min of reaction, it...

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Abstract

The invention belongs to the technical field of medicinal carriers, and provides a charge-guided micro / nano adhesive hydrogel microsphere and a preparation method and application thereof. The preparation method of the hydrogel microsphere comprises the following steps that 1, reacting boric acid ester and dextran to form an amphiphilic block copolymer, adding octadecylamine to obtain a liposome which is positively charged and takes the amphiphilic block copolymer as a core; (2) synthesizing hydrogel by using hyaluronic acid and methacrylic anhydride, mixing the hydrogel and the liposome by using a microfluidic device to prepare hydrogel microspheres, and performing ultraviolet crosslinking to form crosslinked hydrogel microspheres; and (3) grafting dopamine on the surfaces of the crosslinked hydrogel microspheres to obtain the charge-guided micro / nano adhesive hydrogel microspheres. The invention establishes an efficient drug delivery system with cartilage adhesion, cartilage matrix penetration and cartilage cell targeting, solves the problem that the drug is difficult to permeate the cartilage matrix, and is an efficient cartilage drug delivery material with great potential.

Description

Technical field [0001] The invention belongs to the technical field of pharmaceutical carriers, and specifically relates to a charge-guided micro / nano-adhesive hydrogel microsphere and its preparation method and application. Background technique [0002] As we all know, the use of biomaterials to load drugs and the functionalization of biomaterials are the main ways to improve drug efficacy. Among them, improving drug utilization is one of the most important functions of biological materials. It can reduce the dosage of drugs and reduce the toxic and side effects of drugs. Improving the ability of drugs to penetrate tissue is currently one of the most important methods to improve drug utilization. Conventional biomaterials (such as hydrogels and electrospinning) can effectively penetrate drugs into diseased sites, such as tissues with good permeability (such as skin, mucous membranes, muscles, etc.). However, some tissues or organs (such as tumors and brain) often make dru...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/075C08J3/28C08J3/24C08J7/12C08L5/02C08L51/02C08F251/00C08F220/06A61K9/16A61K9/06A61K47/36A61K31/192A61P19/02A61P19/08B82Y5/00B82Y40/00
CPCA61K9/1652A61K9/06A61K9/0024A61K31/192A61P19/02A61P19/08B82Y5/00B82Y40/00C08J3/075C08J3/28C08J3/24C08J7/12C08F251/00C08J2305/02C08J2451/02C08J2351/02C08J2405/02C08F220/06
Inventor 崔文国林峰
Owner 上海市伤骨科研究所
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