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Degradable polyester biological adhesive for combined use of multi-component block polyester, and preparation method and application of degradable polyester biological adhesive

A bio-adhesive and polyester technology, applied in application, surgical adhesives, medical science, etc., can solve problems such as prolonged operation time, incorrect application methods, and difficulties for surgeons, and achieve the effect of improving usability

Active Publication Date: 2022-01-11
BEIJING DATSING BIO TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The cross-linking chemical bond is stable, but the requirement for the exposed area of ​​the gel is relatively high. In reality, there are certain limitations on the bonding surface.
[0007] In order to perform the curing step, the tissue adhesive precursor in all these examples must be deposited as a liquid on the surgical site, which creates difficulties for the surgeon, especially in minimally invasive procedures that require specialized applicators
Improper application may lead to prolongation of operation time or lead to some unintended complications such as thromboembolism

Method used

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  • Degradable polyester biological adhesive for combined use of multi-component block polyester, and preparation method and application of degradable polyester biological adhesive
  • Degradable polyester biological adhesive for combined use of multi-component block polyester, and preparation method and application of degradable polyester biological adhesive

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] This embodiment provides a method for preparing and using a bioadhesive, the steps are as follows:

[0045] (1) ε-caprolactone and DL-lactide are mixed and fed after purification, and then polymerized. The mass ratio of the two monomers is 1:1.

[0046]The toluene solution of stannous octoate was added in the reaction kettle as a catalyst, and the synthesis reaction was carried out under vacuum reaction conditions. The reaction temperature was 200 ° C, and the reaction time was 48 hours. After the reaction was completed, the product was dissolved in methylene chloride, and the clear solution was added to ethanol to obtain The precipitated insoluble matter was dried to obtain the purified block polyester. After purification, the product block ratio of lactide / caprolactone is 7:3, which can be directly used as a bioadhesive with a molecular weight of 30-60KDa.

[0047] The product is packaged in a sealed container (preferably a syringe), see figure 1 , cryopreserved aft...

Embodiment 2

[0051] The difference between this example and Example 1 is that in step (2), the block polyester with a molecular weight of 30KDa obtained in step (1) is used as component A; the block polyester with a molecular weight of 60KDa obtained in step (1) Polyester is used as B component; A and B components are mixed at a mass ratio of 1:1 to obtain a bioadhesive.

Embodiment 3

[0053] This example is the same as Example 1, except that the mass ratio of the two monomers is 2:1.

[0054] In this example, the products A and B were uniformly mixed at a mass ratio of 2:1 or 1:1, packaged in a syringe, sterilized and stored in a freezer. Thaw before use, squeeze out the adhesive and attach it to the surface of the adhered tissue, press to make the adhesive adhere tightly.

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Abstract

The invention relates to a degradable polyester biological adhesive for combined use of multi-component block polyester, and a preparation method and application of the degradable polyester biological adhesive. The biological adhesive provided by the invention is obtained by mixing two block polyesters with different molecular weights. The invention further provides a degradable pressure-sensitive adhesive sticker, an adhesive spray and other innovative modes, and a new application thought can be developed for the biological adhesive. By use of the preparation method provided by the invention, the biological adhesive suitable for different diseases can be obtained by adjusting the molecular weight of the block polyester and the proportion of the multi-component block polyester according to different clinical application requirements.

Description

technical field [0001] The invention relates to the technical field of polymer organic synthesis, in particular to a degradable polyester bioadhesive used in combination with multi-component block polyesters, a preparation method and application thereof. Background technique [0002] In general surgery, tissue adhesives can reduce tissue damage by noninvasively immobilizing organs or biomedical devices, potentially eliminating the need for sutures or staplers during certain surgical procedures. Medical sealant has been used clinically at present to bond wounds, prevent leakage, prevent adhesion, and fix tissues. It is widely used in soft tissue adhesion: such as general surgery, thoracic surgery, neurosurgery, gynecology, etc. Wait. [0003] The bonding mechanism of the currently marketed medical degradable synthetic adhesives is mainly divided into covalent bond interaction and hydrogen bond interaction. The currently marketed bioadhesive bonding methods are mainly liquid...

Claims

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Application Information

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IPC IPC(8): A61L24/04A61L24/00C08G63/08C08G63/85
CPCA61L24/043A61L24/001A61L24/0042A61L24/0026C08G63/08C08G63/823C08L67/04
Inventor 周天泓牛睿李晓盟李俊昊刘紫薇江艳翟晖代金明
Owner BEIJING DATSING BIO TECH
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