Hydrogel for in-vivo release of medication

A hydrogel and drug technology, applied in the direction of drug combination, drug delivery, prosthesis, etc.

Pending Publication Date: 2022-01-14
UMC UTRECHT HLDG BV +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] Furthermore, few hydrogels meet the stringent requirements for clinical translation in terms of hydrogel preparation, application, mechanical properties, and biocompatibility.

Method used

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  • Hydrogel for in-vivo release of medication
  • Hydrogel for in-vivo release of medication
  • Hydrogel for in-vivo release of medication

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0072] Use the method described in the instructions.

[0073] Material:

[0074] Gelatin (porcine skin, type A, 300 g gel strength), 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide (EDC), N-hydroxysuccinimide (NHS), Tyramine hydrochloride, 2-morpholineethanesulfonic acid monohydrate (MES), sodium persulfate (SPS), sodium bicarbonate (NaHCO 3 ), sodium periodate, β-cyclodextrin, glycerol, phosphate buffered saline (PBS), riboflavin (RB) and ethylene glycol were purchased from Sigma Aldrich. Cellulose Dialysis Membrane (Spectrum / Por TM , 0,5 kDa; 12 kDa molecular weight cut-off) was purchased from Spectrum Laboratories. Bupivacaine was obtained from Siegfried, Switzerland.

[0075] Synthesis of gelatin-tyramide (GTA):

[0076] Type A gelatin was dissolved in MES buffer at 50°C, then tyramide, EDC and NHS were added. The reaction mixture was stirred overnight. The mixture was then dialyzed against water and the product was obtained by lyophilization.

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Abstract

The present invention relates to a hydrogel for in-vivo release of medication comprising at least one medication, wherein the hydrogel comprises (i) a protein-based biopolymer functionalized with a functionalisation agent that is able to form guest-host interactions with oxidized beta-cyclodextrin, preferably a primary aminoalkylphenol, more preferably gelatin functionalized with tyramine (GTA) and (ii) oxidized beta-cyclodextrin (o[beta]-CD), wherein the hydrogel is cross-linked via exposure to visible light in presence of a biocompatible photoinitiator, resulting in a degree of swelling in the range of 2-20 calculated as (swollen weight- dry weight) / dry weight. It further relates to a method for its preparation, as well as to a medication for treatment of musculoskeletal disorders, preferably for treatment of infection, inflammation, malignant processes, growth disorders, degenerative disorders or treatment of pain arising from (surgical treatment of) these disorders.

Description

technical field [0001] The present application relates to hydrogels for in vivo release of drugs. In particular, the controlled and localized release of drugs such as bupivacaine and / or other local anesthetics is concerned. More particularly, the present invention relates to hydrogels for intimate contact with scaffolding structures. The invention further relates to methods for their in vitro and in vivo preparation. Background technique [0002] Hydrogels are three-dimensional physically or chemically crosslinked networks of water-soluble polymers. Their hydrophilicity, water content and elasticity similar to living tissue make them excellent candidates for biomedical applications. Thus, there is considerable prior art on biodegradable hydrogels designed to release drugs in a sustained manner in vivo (human or animal). [0003] For example, in "J. Adv. Res. 2017, 8, 217-233", E.A. Kamoun et al. conducted a comprehensive review of hydrogels and their medical applications...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K31/445A61K45/00A61K47/40A61K47/42A61L27/34A61L27/52A61L27/54A61P23/02
CPCA61K9/06A61K47/42A61K47/40A61K45/00A61K31/445A61P23/02A61L27/34A61L27/52A61L27/54A61L2300/216A61L2300/402A61L2300/602C08L89/00C08L5/16A61K47/6951A61K47/6903A61K47/61A61P19/00A61K45/06A61K9/0024A61K9/127A61K2300/00A61P31/00A61P29/00A61K47/6915
Inventor 苏珊娜·皮卢索贾斯珀·格拉尔德·斯蒂弗林克约安内斯·雅各布斯·韦尔朗巴斯·耶罗·奥斯特曼
Owner UMC UTRECHT HLDG BV
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