Application of Houttuynia cordata Thunb. polysaccharide in preparation of medicine for preventing and treating inflammatory bowel disease

A technology of inflammatory bowel disease and Houttuynia cordata, which is applied in the field of Houttuynia cordata polysaccharides in the preparation of drugs for the prevention and treatment of inflammatory bowel disease, and can solve the problems of the efficacy of Houttuynia cordata inflammatory bowel disease and drug research reports that have not been seen.
CN113940945APending Publication Date: 2022-01-18FUDAN UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
FUDAN UNIV
Publication Date
2022-01-18

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Abstract

The invention belongs to the technical field of traditional Chinese medicines, and relates to a novel pharmaceutical application of Houttuynia cordata Thunb. polysaccharide, in particular to the application of the Houttuynia cordata Thunb. polysaccharide in preparation of a medicine for preventing and treating inflammatory bowel disease (IBD). A total polysaccharide extract is separated and extracted from the traditional Chinese medicine Houttuynia cordata Thunb., the average product yield is 3.65%, and the polysaccharide content exceeds 70%. An integral experiment proves that the total polysaccharide extract of the Houttuynia cordata Thunb. has a remarkable treatment effect on mouse colonic injury induced by 2.5% DSS. The Houttuynia cordata Thunb. polysaccharide may inhibit infiltration of inflammatory cells, reduce secretion of inflammatory cytokines and inhibit expression of an inflammatory transcription factor NF [kappa] B through an anti-inflammatory mechanism of the Houttuynia cordata Thunb. polysaccharide, so that intestinal injury is reduced, intestinal mucosa is protected, and colon shortening and weight loss are relieved. The Houttuynia cordata Thunb. polysaccharide can be used for preparing medicines for preventing and treating ulcerative colitis.
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Description

technical field

[0001] The invention belongs to the technical field of traditional Chinese medicine, and relates to the new pharmaceutical application of Houttuynia cordata polysaccharide, in particular to the application of Houttuynia cordata polysaccharide in preparing medicines for preventing and treating inflammatory bowel disease (IBD). Background technique

[0002] The prior art discloses that inflammatory bowel disease is caused by various reasons such as genes, environment, and immunity. The common types of inflammatory bowel disease include ulcerative colitis (ucerative colitis, UC) and Crohn's disease (CD); wherein, ulcerative colitis mainly occurs in the mucosal layer of the rectum and colon, with ulcers, erosions Mainly, often involving the entire colon, showing continuous large-scale lesions[1], the clinical manifestations of UC are recurrent diarrhea, abdominal pain, nausea, vomiting, bloody stool, fever and malnutrition, which may be accompanied by skin, mucou...

Claims

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