Percutaneous bilirubin detection method and device

Abstract

The invention discloses a percutaneous bilirubin detection method and device; the method comprises the steps: building a data model through the correlation between the concentration of bilirubin and the absorptivity of a detection spectrum, and predicting the concentration of the percutaneous bilirubin through collecting the absorptivity of optical radiation energy with different wavelengths according to the built data model. In the method, a reference wavelength which does not change along with the concentration of bilirubin is obtained by using a floating reference method measurement theory; wherein in the data model, the absorptivity of the reference wavelength and the absorptivity at other wavelengths set by the data model are used for making a difference, a percutaneous bilirubin concentration prediction value eliminating the influence of the human body state change is obtained, and the influence of hemoglobin on a percutaneous bilirubin test is eliminated through the radiation absorptivity of a 550nm wave band test; thus, the influence of melanin on the percutaneous bilirubin test is eliminated through the radiation absorptivity tested at the wave bands of 660nm and 740nm, so that the concentration of the percutaneous bilirubin of the human body can be conveniently, quickly and accurately tested.

Description

technical field [0001] The invention relates to the field of medical detection, in particular to a method and device for percutaneous bilirubin detection. Background technique [0002] Bilirubin (BR for short) is an intermediate or product of the catabolism of hemoglobin and other compounds in animals, and generally only exists in the blood. It is not only an endogenous toxin, but also an endogenous antioxidant. Cells have a protective function. Abnormal metabolism of bilirubin can cause a series of diseases, such as jaundice, coronary heart disease, cerebrovascular disease and pigmented gallstones, so people take the determination of serum bilirubin concentration as one of the daily liver and gallbladder function tests It is an important test item, which makes the detection of bilirubin clinically significant. The normal content range of bilirubin in the human body is 0.2-1.0 mg / dl, and the detection range is 0-20 mg / dl. In addition, jaundice, as one of the most typical d...

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Problems solved by technology

[0003] At present, there are two types of transdermal bilirubin detection products on the market, one adopts the dual-wavelength method, and the other uses the absorption value of two wavelengths to make a difference to remove the interference of hemoglobin on the detection of bilirubin. The obtained result is called Transcutaneous bilirubin value, the measurement accuracy of this method is poor; multi-wavelength method, using multi-wavelength spectral detection method, using the linear correlation between bilirubin concentration and detection spectral data to establish a correlation model, and use this model to predict human bilirubin concentration

However, because the bilirubin concentration in the human body is relatively low and there are many factors that affect the non-invasive optical detection of bilirubin, the bilirubin concentration information is submerged in various noises and other information, so its accuracy is relatively invasive. It is also not ideal. At the same time, the use of multiple incident wavelengths will inevitably increase the cost of the instrument and increase the complexity of the data processing algorithm, which will affect the popularization and application of the instrument.

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