Application of hydrogen molecules in preparation of medicine or food for regulating intestinal flora

A technology for regulating intestinal flora and hydrogen molecules, applied in the field of medicine, can solve problems such as the inability to explain the role of hydrogen prevention and control, and achieve the effect of optimizing the structure of intestinal flora and increasing relative abundance

Pending Publication Date: 2022-02-11
BEIJING UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Although it has been found that hydrogen has anti-oxidation, anti-inflammation and anti-apoptosis effects, and has shown a good effect on the prevention and treatment of many diseases, the specific mechanism of hydrogen in organisms so far is limited to the fact that hydrogen can be selectively removed. Hydroxyl radicals, obviously this does not explain the prevention and treatment effect of hydrogen on various diseases discovered so far

Method used

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  • Application of hydrogen molecules in preparation of medicine or food for regulating intestinal flora
  • Application of hydrogen molecules in preparation of medicine or food for regulating intestinal flora
  • Application of hydrogen molecules in preparation of medicine or food for regulating intestinal flora

Examples

Experimental program
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Effect test

Embodiment 1

[0034] 1. Experimental animals

[0035] In the experiment, 6-week-old male Sprague-Dawley rats (purchased from Vital River Experimental Animal Technology Co., Ltd.) were used to maintain a 12-hour light-dark cycle under standard conditions of 22°C to 25°C, and fed with normal diet. All experimental protocols were approved by the Animal Experiment Committee of the General Hospital of the Chinese People's Liberation Army and implemented in accordance with the Regulations on the Administration of Experimental Animals (China). Before the experiments, the animals acclimated to laboratory conditions for a week.

[0036] The rats were randomly divided into 2 groups, and the experimental period was 6 months:

[0037] (1) Control group (Control): Drink pure water for 1 hour twice a day at 9:00 am and 17:00 pm, and deprive of water for the rest of the time. Rats in the two groups are free to eat and drink, and breathe normal air.

[0038] (2) Drinking hydrogen-rich water group (HRW): ...

Embodiment 2

[0079] 1. Experimental animals

[0080] In the experiment, 6-week-old male Sprague-Dawley rats (purchased from Vital River Experimental Animal Technology Co., Ltd.) were used to maintain a 12-hour light-dark cycle under standard conditions of 22°C to 25°C, and fed with normal diet. All experimental protocols were approved by the Animal Experiment Committee of the General Hospital of the Chinese People's Liberation Army and implemented in accordance with the Regulations on the Administration of Experimental Animals (China). Before the experiments, the animals acclimated to laboratory conditions for a week.

[0081] The rats were randomly divided into 2 groups, and the experimental period was 6 months:

[0082] (1) Control group (Control): Drink pure water for 1 hour twice a day at 9:00 am and 17:00 pm, and deprive of water for the rest of the time. Rats in the two groups are free to eat and drink, and breathe normal air.

[0083] (2) Drinking low-concentration (0.2mM) hydroge...

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Abstract

The invention discloses application of hydrogen molecules in the preparation of a medicine or food for regulating intestinal flora. The carrier form of the hydrogen molecules is a hydrogen-rich liquid, and the hydrogen concentration in the hydrogen-rich liquid is not lower than 1.0 mmol / L. The invention also provides the medicine or food for regulating intestinal flora. The medicine or food is the hydrogen-rich liquid with the hydrogen concentration of not less than 1.0 mmol / L. The hydrogen-rich liquid can regulate the steady state of intestinal flora, especially can significantly increase the relative abundance of probiotics Lactobacillus and Bifidobacterium in the intestinal flora of healthy rats, optimizes the structure of the intestinal flora, also can increase the content of short-chain fatty acids such as acetic acid and propionic acid in excrement, namely intestinal content, and also can regulate the hydrogen production capacity of the intestinal flora to influence the hydrogen yield.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to the application of hydrogen molecules in preparing medicine or food for regulating intestinal flora and a medicine or food for regulating intestinal flora. Background technique [0002] Hydrogen biology is an emerging and promising therapeutic strategy that uses molecular hydrogen (H 2 ) as a new type of safe and effective therapeutic agent. For a long time, hydrogen has been considered as a physiologically inert gas. It was not until modern medicine that the medical effects of hydrogen were discovered. In 2007, Professor Ota Chengao of Japan Medical University published a paper in the internationally renowned medical journal "Natural Medicine", proving that inhaling a small amount of hydrogen (2%) under normal pressure can effectively treat ischemic stroke in rats. It has also been further confirmed in clinical trials. Since hydrogen is a gas that has long been f...

Claims

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Application Information

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IPC IPC(8): A61K33/00A61P1/00A23L2/38A23L2/54A23L33/10
CPCA61K33/00A61P1/00A23L2/38A23L2/54A23L33/10A23V2002/00A23V2200/32A23V2250/12
Inventor 谢飞马雪梅赵鹏翔刘梦昱
Owner BEIJING UNIV OF TECH
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