74 results about "Genus Bifidobacterium" patented technology

The invention belongs to the field of food, and particularly relates to a nutritional composition containing probiotics and breast milk oligosaccharide for improving anxiety or depression and application of the nutritional composition. The invention provides application of a nutritional composition in preparation of food beneficial to improving constipation and anxiety state and / or depression state caused by constipation. Wherein the nutritional composition comprises the following components (i) and (ii): (i) a bifidobacterium probiotic, and (ii) a sialylated breast milk oligosaccharide; the bifidobacterium probiotics at least comprise animal bifidobacterium subsp. Lactis, the sialylated breast milk oligosaccharide at least comprises 6 '-sialylated lactose, and the animal bifidobacterium subsp. Lactis comprises a Bb-12 strain. The substance combination of the bifidobacterium probiotics and the sialylated breast milk oligosaccharide can synergistically improve abnormal brain-intestine interaction, and improve constipation and anxiety and / or depression state caused by constipation.

The invention discloses bifidobacterium breve and application thereof in relieving Alzheimer's disease, and belongs to the technical field of probiotics. The preparation method comprises the following steps: separating 18 bifidobacterium strains from feces of children aged 0-3 years old, analyzing and identifying the 18 bifidobacterium strains including bifidobacterium longum, bifidobacterium breve and bifidobacterium animalis, and screening out the bifidobacterium breve LE4 with potential Alzheimer's disease relieving capacity through in-vitro oxidation resistance and LPS (Lipopolysaccharide) removal capacity. The method comprises the steps of behavioral experiments (nesting experiments, open field experiments and water maze experiments), histopathologic analysis, molecular biological detection and the like. The multi-target AD intervention effects of improving the cognitive function, reducing A beta deposition and tau protein phosphorylation, relieving neuroinflammation, enhancing synaptic plasticity, repairing intestinal barriers, adjusting intestinal flora and metabolites and the like of the LE4 strain are comprehensively evaluated, and a new strategy is provided for promoting AD micro-ecological treatment.

The invention belongs to the field of food, and particularly relates to a nutritional composition containing breast milk oligosaccharide and probiotics for improving depression and application of the nutritional composition. The invention provides application of a nutritional composition in preparation of food beneficial to improving constipation and anxiety state and / or depression state caused by constipation. Wherein the nutritional composition comprises the following components (i) and (ii): (i) a neutral fucosylated breast milk oligosaccharide, and (ii) a bifidobacterium probiotic; the neutral fucosylated breast milk oligosaccharide at least comprises 2 '-fucosylated lactose, and the bifidobacterium probiotics at least comprise bifidobacterium longum subsp. Longum. According to the present invention, the substance combination of the neutral fucosylated breast milk oligosaccharide and the bifidobacterium probiotic can improve the abnormal brain-intestine interaction, such that the constipation can be easily improved, and the anxiety and depression state caused by the constipation can be easily improved;

The invention belongs to the field of food, and particularly relates to a nutritional composition of oligosaccharide and probiotics and application of the nutritional composition. The invention provides application of a nutritional composition in preparation of food beneficial to improvement of constipation and improvement of cognitive competence decline caused by constipation. Wherein the nutritional composition comprises the following components (i) and (ii): (i) a neutral fucosylated breast milk oligosaccharide, and (ii) a bifidobacterium probiotic; wherein the neutral fucosylated breast milk oligosaccharide at least comprises 2 '-fucosylated lactose, and the bifidobacterium probiotics at least comprise bifidobacterium longum subsp. Longum. According to the present invention, with the substance combination of the neutral fucosylated breast milk oligosaccharide and the bifidobacterium probiotic, the abnormal brain-intestine interaction can be improved, such that the constipation can be easily improved, and the cognitive ability reduction caused by the constipation can be easily improved;

The invention relates to application of bifidobacterium breve BBr60 in preparation of a probiotic preparation for improving atopic dermatitis. The bifidobacterium breve BBr60 is a bifidobacterium breve BBr60 strain of which the preservation number is CGMCC (China General Microbiological Culture Collection Center) No.12915, and the bifidobacterium breve BBr60 strain of which the preservation number is CGMCC No.12915. The invention develops a new application of the bifidobacterium breve BBr60, provides a research basis for wide application of the bifidobacterium breve BBr60, also develops a brand new strategy for improving atopic dermatitis, discovers that the bifidobacterium breve BBr60 has a very remarkable effect on improving atopic dermatitis, and has a very good application prospect. Specifically, the skin lesion phenomenon and the mast cell inflammation infiltration phenomenon in the skin of an atopic dermatitis model mouse are remarkably improved; the IgE level in serum of an atopic dermatitis model mouse is remarkably reduced and improved, the levels of IFN-gamma and IL-10 are improved, and Th1 / Th2 immune balance is recovered; the intestinal flora uniformity of atopic dermatitis model mice is recovered, and the relative abundance and F / B ratio of bifidobacterium and lactobacillus in the intestinal flora of the mice are remarkably improved.

The present application relates to; a pharmaceutical composition, a food composition and a feed composition for preventing or treating fatty liver diseases; and a method for treating fatty liver diseases by using same, the pharmaceutical composition comprising a Bifidobacterium pseudolongum strain deposited under accession number KCTC 15133BP, a culture of the strain, a lysate of the strain, an extract of the strain, or a mixture thereof. The Bifidobacterium pseudolongum strain deposited under accession number KCTC 15133BP, a culture of the strain, a lysate of the strain, an extract of the strain, or a mixture thereof, according to the present invention, alleviates inflammatory cell infiltration and fibrosis in the liver, and exhibits the effects of inhibiting cholesterol synthesis and inhibiting triglyceride accumulation in the liver, and thus can be used for treating fatty liver diseases, particularly nonalcoholic fatty liver disease.

The invention provides application of a probiotic composition in preparation of a medicine for preventing and / or treating Alzheimer's disease, and belongs to the technical field of probiotic medical application. The probiotic composition disclosed by the invention is prepared from lactobacillus rhamnosus, bifidobacterium lactis and bifidobacterium bifidum. According to the probiotic composition disclosed by the invention, on the phylum level, the relative abundance of Verrucomicrobiota (verruca microflora phylum) is improved by the probiotic composition, and the relative abundance of the verrucomicrobiota (verruca microflora phylum) is improved by the probiotic composition; in the level of genus, the probiotic composition increases the relative abundance of the beneficial bacteria genus Akkermansia (Ackermania genus) and Bifidobacterium (Bifidobacterium genus), and in the level of genus Akkermania (Ackermania genus) and Bifidobacterium (Bifidobacterium genus); the behavioral cognition level can be remarkably improved, neuron injury is improved, and intestinal barrier injury is improved.

The invention belongs to the field of food, and particularly relates to a nutritional composition containing probiotics and oligosaccharides for improving cognition and application of the nutritional composition. A use of a nutritional composition in the preparation of a food product helpful to ameliorate constipation and helpful to ameliorate cognitive competence decline caused by constipation; wherein the nutritional composition comprises the following components (i) and (ii): (i) a bifidobacterium probiotic, and (ii) a sialylated breast milk oligosaccharide; the bifidobacterium probiotics at least comprise animal bifidobacterium subsp. Lactis, and the sialylated breast milk oligosaccharide at least comprises 6 '-sialylated lactose. According to the present invention, the substance combination of the bifidobacterium probiotics and the sialylated breast milk oligosaccharide can improve the abnormal brain-intestine interaction, such that the constipation can be easily improved, and the cognitive competence reduction caused by the constipation can be easily improved; in addition, the bifidobacterium probiotics and the sialylated breast milk oligosaccharide also have a synergistic interaction effect.

The invention provides thesium chinense polysaccharide as well as a preparation method and application thereof, compared with the prior art, neutral polysaccharide TP1 is efficiently extracted from thesium chinense by adopting a hot water extraction method, the neutral polysaccharide TP1 mainly comprises fructose, glucose and galactose according to a molar ratio of 44.7: 33.8: 17.9, and the molecular weight Mw of the TP1 measured by adopting a GPC-RI-MALS chromatographic method is 5377Da. The invention also researches the protective effect of thesium chinense polysaccharide on DSS-induced colitis. The TP1 reduces the loss of intestinal tight junction proteins (Claudin-1, Occludin and ZO-1), regulates the abundance of bacteria in the intestinal tract and enriches bacteria (ruminococcus, lactobacillus and bifidobacterium) capable of generating SCFAs, in addition, the TP1 increases the expression of GPR41 and GPR43 receptors in colon tissues, and the symptoms of colitis are relieved by reducing oxidative stress and inflammatory cytokine levels through the GPR41 and GPR43 receptors mediated by the SCFAs. The thesium chinense polysaccharide TP1 prepared by the invention can be used for preparing medicines for preventing and treating colitis and also can be used for preparing food.

The objective of this invention is to provide: aerobic-tolerant Bifidobacterium spp. capable of being cultured under aerobic conditions, a method for culturing the same and a method for screening it, and a composition comprising aerobic-tolerant Bifidobacterium spp. and a method for manufacturing the same. The present invention that solves this problem is a method for culturing Bifidobacterium bacteria, comprising the step of culturing Bifidobacterium bacteria having any one of the following (1) to (7) under aerobic conditions: (1) a gene consisting of a base sequence shown in sequence number 1 or 2; (2) a gene having more than 90% identity with a base sequence shown in sequence number 1 or 2; (3) a gene consisting of a base sequence in which 1 to several bases are missing, substituted, or added to a base sequence shown in sequence number 1 or 2; (4) a gene consisting of a base sequence of DNA that can hybridize under strict conditions with a DNA consisting of a complementary sequence of a base sequence shown in sequence number 1 or 2; (5) a gene consisting of a degenerate isomer of a base sequence shown in sequence number 1 or 2; (6) a gene encoding a protein consisting of an amino acid sequence shown in sequence number 3 or 4; (7) a gene encoding a protein consisting of an amino acid sequence in which 1 to several amino acids are missing, substituted, or added to an amino acid sequence shown in sequence number 3 or 4.

The present invention provides: a composition for controlling the proliferation of butyrate-producing bacteria, said composition comprising at least one substance selected from among sugar alcohols and derivatives thereof; a composition for controlling butyrate production, said composition comprising a sugar alcohol derivative; a composition for controlling the proliferation of bacteria of the genus Bifidobacterium, said composition comprising a sugar alcohol derivative; and uses of the same.

The application provides bifidobacterium longum MG-G763 for improving constipation, and belongs to the technical field of microorganisms. The bifidobacterium longum MG-G763 provided by the application can effectively relieve constipation by integrating multiple effects such as nerve regulation, immune regulation, barrier repair and flora regulation, and systematically restoring intestinal function homeostasis. The bifidobacterium longum MG-G763 can significantly improve the defecation particle number and defecation weight of constipated mice, shorten the time for defecating the first black stool, improve the small intestinal transport rate of the mice, effectively improve and relieve the defecation condition of the constipated mice, and significantly increase the amount of intestinal beneficial bacteria and reduce the amount of harmful bacteria, thereby promoting intestinal health.

The present invention relates to a method for treating conditions associated with weight loss in emaciation and cachexia with a probiotic composition and the use of a probiotic composition in the treatment of conditions associated with weight loss in emaciation and cachexia. The present invention provides a method of treating a condition associated with weight loss, the method comprising administering to a subject considered in need of such treatment a probiotic composition wherein the composition comprises at least two bacteria, each preferably selected from a different genus, the genus is preferably selected from the group consisting of Lactobacillus genus, Enterococcus genus and Bifidobacterium genus. The present invention also provides a probiotic composition for use in the treatment of a subject suffering from a condition associated with weight loss wherein the composition comprises at least two bacteria each preferably selected from a different genus, preferably selected from the group consisting of Lactobacillus genus, Enterococcus genus and Bifidobacterium genus.

The present invention addresses the problem of providing a novel functionality of a Bifidobacterium longum subsp. Infantis M-63 (NITE BP-02623), and a method for producing the same, and more particularly, to provide a novel functionality of a Bifidobacterium longum subsp. Infantis M-63 (NITE BP-02623). A composition to be ingested by healthy neonates or infants who are born for a full month contains, as an active ingredient, one or more species selected from the group consisting of a cell of Bifidobacterium longum subsp. Infantis M-63 (NITE BP-02623), a culture of the cell, and a treated product of the cell. The composition is used for promoting colonization of bifidobacterium bacteria in intestinal flora, promoting maturation of intestinal function, inhibiting milk spilling or regulating immune function.

The present invention relates to bacteria, compositions and methods for their production, and prebiotic compositions. By the present invention, novel Bifidobacterium bacteria having assimilation ability of two or more HMOs are provided. The bacteria are selected from the group consisting of Bifidobacterium longum subsp. infantis (NITE BP-03068), Bifidobacterium bifidum (NITE BP-03058), and Bifidobacterium bifidum (NITE BP-03067).

A cosmetic treatment method comprising application of a composition comprising at least one antioxidant and a Bifidobacterium spp. lysate. The present invention relates to a method for the cosmetic treatment of the scalp and hair comprising application of a composition comprising at least one specific antioxidant, a Bifidobacterium spp. lysate and water. Preferably, the cosmetic treatment method of the present invention is a method for caring for and / or conditioning the scalp and hair.

To provide a composition that increases the occupancy rate of bacterium of the genus Parabacteroides and bacterium of the genus Bifidobacterium in intestinal flora.SOLUTION: A composition for improving intestinal flora is provided, the composition containing any one material selected from trehalulose, isomaltulose, turanose, maltulose, and oligosaccharides containing any one material from these materials as a constituent sugar.SELECTED DRAWING: Figure 1

COMPOSITION AND METHOD FOR THE CARE OF KERATINOUS MATERIALS The present invention relates to a composition, preferably for the care of keratinous materials, comprising: a) at least one microorganism of the species of the genus Bifidobacterium, the microorganism being in lysate form, b) at least one extract of Salvia miltiorrhiza, and c) an extract of Sphingomonas ferment. The present invention also relates to a non-therapeutic method for the care of keratinous materials, comprising the application of said composition to the keratinous materials. Figure for the abstract: none

The invention relates to a method for enriching and screening bifidobacterium intestinal bacteria, and aims to efficiently separate bifidobacteria from complex intestinal flora. The method comprises the steps of basic anaerobic culture medium preparation, enrichment culture, enrichment culture, intestinal bacterium nucleic acid extraction, high-throughput sequencing and analysis, strain separation and culture, intestinal bacterium molecular identification and the like. Through a unique culture medium formula and culture conditions, efficient enrichment and screening of bifidobacteria can be realized under common laboratory conditions without professional anaerobic equipment. The method overcomes the problems of harsh growth conditions of bifidobacteria, low selective culture medium efficiency and the like in the prior art, and provides technical support for deep research and application of bifidobacteria.

This chronic kidney disease progression inhibitor utilizes Bifidobacterium bifidum as an active ingredient. As a result, present invention provides an agent that is more effective by using a bacterial strain that is different from hitherto-reported bacteria that belong to the genus Bifidobacterium and that have been used against chronic kidney diseases.

The invention discloses a fluorescent quantitative detection kit for bifidobacteria in intestinal microorganisms and application of the fluorescent quantitative detection kit. The invention provides a complete set of single-stranded DNA for detecting a bifidobacterium strain. The complete set of single-stranded DNA is composed of a primer pair and a single-stranded DNA probe, the primer pair is composed of an upstream primer as shown in SEQ ID No. 1 and a downstream primer as shown in SEQ ID No. 2; the nucleotide sequence of the single-stranded DNA probe is as shown in SEQ ID No. 3. The method is simple and fast in period; the probe method real-time fluorescent quantitative PCR detection is high in targeting property, and the number of bifidobacteria in a sample can be reduced to a greater extent; the primer and the probe group have high specificity, bifidobacterium can be identified in complex intestinal microorganisms, and various strains under the bifidobacterium can be effectively amplified; the qualitative and quantitative detection of bacteria genus can be simultaneously realized, and the quantification is more accurate; according to the detection result, guiding significance is provided for probiotic supplement of the detected person.

Provided are a technique capable of reducing harmful bacteria without reducing beneficial bacteria, as well as a flora improver and an antibacterial agent using the same. According to the present invention, the number of harmful bacteria can be suppressed without suppressing the number of beneficial bacteria. Therefore, according to the present invention, the flora can be effectively improved. In addition, since the antibacterial agent of the present invention does not reduce beneficial bacteria, it is expected to reduce side effects such as diarrhea caused by the decrease in beneficial bacteria. 【Solution means】 A flora improver characterized by using agarooligosaccharide as an active ingredient and using the active ingredient in any of the following usage amounts (a) to (c); (a) A usage amount that does not suppress the number of bacteria belonging to the genus Bifidobacterium, (b) A usage amount that does not suppress the number of bacteria belonging to the genus Lactobacillus, (c) A usage amount of 80 mg or more and less than 12,000 mg per day.

The invention relates to application of a fermentation product of fermented pichia pastoris 15B1 in proliferation of intestinal probiotics, and belongs to the technical field of biology. The fermentation product of the fermented pichia pastoris 15B1 disclosed by the invention has the effect of promoting the proliferation of Collinsella and Bifidobacterium in intestinal bacteria, and can be used as a new prebiotic additive.

Provided is a bacterium belonging to Bifidobacterium pseudocatenuicola, which is capable of using xylan and has excellent survivability in a culture medium containing a milk component. The bacterium belonging to the Bifidobacterium pseudocatenum has a xylanase gene on a genome, and the survivability of the bacterium in a culture medium containing milk components is higher than that of the Bifidobacterium pseudocatenum YIT 11057 (NITE BP-02930).

Cosmetic compositions for improving the barrier function of the skin The present invention relates to a cosmetic composition comprising, in a physiologically acceptable medium, at least one microorganism of the genus Bifidobacterium and / or one of its fractions and / or one of its metabolites, at least one yeast extract of the genus Saccharomyces, at least one monosaccharide, preferably mannose or rhamnose, at least one gluco-oligosaccharide (GOS), at least one fructo-oligosaccharide (FOS), at least one beta-glucan and / or its derivatives and / or its salts such as sodium carboxymethyl beta-glucan, at least glycyrrhizic acid and / or its salts such as dipotassium glycyrrhizate, and at least hyaluronic acid and / or its salts.It also relates to the use of said cosmetic composition for skin care, preferably for improving the barrier function, as well as a cosmetic treatment method for skin care, in particular for improving the barrier function, comprising the application of said composition. Figure for abstract: none.

The invention belongs to the technical field of food, and particularly relates to a nutritional composition for promoting growth of intestinal healthy flora and application of the nutritional composition. Compared with the prior art, the lactoferrin, the calcium, the iron and the zinc in the nutritional composition provided by the invention can promote the abundance of bifidobacterium and the abundance of bifidobacterium breve in the intestinal tracts of infants, the richness and the species number of flora in the intestinal tracts of the infants are remarkably increased, and the flora state closer to that of breast feeding is formed.

The invention discloses a novel Bifidobacterium strain, namely IMAU50987, and belongs to the technical field of bifidobacteria. The invention further discloses a preparation method of the novel Bifidobacteria strain, namely IMAU50987. The invention provides a novel bifidobacterium strain IMAU50987, the 16S rRNA sequence of the strain is as shown in SEQ ID NO.1, and the strain is separated from cliff black honeycomb honey in Dai nationality, Jingyan nationality, Autonomous Dai nationality, Liangghe County, Dehong, Yunnan Province. The strain is preserved in Guangdong Microbial Culture Collection Center on August 8th, 2024, the address is the 5th floor of the Experimental Building, No.100 Court, Middle Xianlie Road, Guangzhou City, Guangdong Province, and the preservation number is GDMCC No: 64993, and the strain is preserved in Japan Microbial Culture Collection Center on October 3th, 2023, the address is Institute of Physical and Chemical Research, Tsubao City, Japan Shuzhou County, and the preservation number is JCM 36315. The novel bifidobacterium strain IMAU50987 grows well on an mMRS agar culture medium, the optimum growth temperature is 35 DEG C, the optimum pH is 6, the bacterial colony is round, semitransparent and convex after being cultured for 72 hours, and the diameter is about 1 mm; two drug-resistant genes and two virulence genes are retrieved in the genome, hemolysis is avoided, and the gene is sensitive to various antibiotics.

A composition, preferably for caring for keratin materials, comprise: a) at least one microorganism of the genus Bifidobacterium species, the microorganism being in the lysate form, b) at least one Salvia miltiorrhiza extract, and c) Sphingomonas ferment extract. A non-therapeutic method for caring for the keratin materials comprises applying the composition to the keratin materials.

The invention relates to application of a fingered citron extract in preparation of a medicine for treating metabolic syndrome, and belongs to the technical field of biological medicines. According to the fingered citron extract disclosed by the invention, the diversity of flora can be improved by regulating intestinal flora, and the relative abundance of beneficial bacteria Akkermansia is specifically increased, so that the metabolic syndrome induced by high fat diet is relieved. An embodiment verifies that the scheme of the invention not only can significantly inhibit weight gain of obese mice induced by high fat diet, improve glucose metabolism disorder (including reduction of fasting blood-glucose and improvement of oral glucose tolerance), relieve liver fat accumulation and pathological damage, reduce visceral fat accumulation and improve adipocyte hypertrophy, but also can significantly inhibit the weight gain of the obese mice induced by high fat diet and improve the glucose metabolism disorder (including reduction of fasting blood-glucose and improvement of oral glucose tolerance). And obesity-related metabolic hormone disorder can be effectively reversed, for example, the serum insulin level is improved, and the leptin level is reduced.

1. An orally administered composition for use in the prevention and / or treatment of degenerative eye diseases, comprising a lysate of probiotic microorganisms in the form of a dry powder of the genera Bacillus, Lactobacillus, Streptococcus, Saccharomyces, and Bifidobacterium.