The invention discloses a
bifidobacterium bifidum capable of reducing colon
pathological injury and relieving
constipation, and belongs to the field of microorganisms. The
bifidobacterium bifidum CCFM1165 provided by the invention can effectively improve the first black stool time, the intestinal tract propulsion rate, the stool
water content and the
pathological damage of colon tissues of a
constipation mouse. The strain provided by the invention can influence the content of excitement type and inhibition type gastrointestinal active peptides, and mainly increases the content of two short-chain fatty acids, so that the
constipation symptom is relieved. Meanwhile, the
bifidobacterium bifidum can effectively increase the abundance of bifidobacteria in excrement and can also relieve
pathological damage of
colon tissue, so that the effect of comprehensively relieving constipation diseases is achieved. In addition, compared with GDMCC NO.60939, the content of MTL in serum is better increased,
secretion of 5-HT in
colon tissue is promoted, and the propelling effect on
small intestine peristalsis is more remarkable, so the GDMCC NO.60939 can be applied to
disease control in a more targeted mode.