177 results about "Sporobacterium" patented technology

The invention discloses a microbacterium capable of producing siderophores, dissolving potassium, promoting growth and relieving saline-alkali stress of plants and application of the microbacterium. The invention relates to the field of microorganisms, and provides a dendrobium nobile microbacterium, the dendrobium nobile microbacterium is a dendrobium nobile microbacterium, the strain number of the dendrobium nobile microbacterium is 2T1, and the registration number of the dendrobium nobile microbacterium in the China General Microbiological Culture Collection Center is CGMCC No. 32856. The strain is a new strain of microbacterium and has the capabilities of secreting siderophores and dissolving potassium. Pot experiments show that compared with uninoculated control, the root length and dry weight of wheat can be improved after the strain is inoculated under saline-alkali stress. The microbacterium dendrobii 2T1 can be used as a microbial organic fertilizer, and is used for improving the soil fertility, relieving the saline-alkali stress of crops and improving the saline-alkali adaptability of the crops.

The invention discloses bifidobacterium breve and application thereof in relieving Alzheimer's disease, and belongs to the technical field of probiotics. The preparation method comprises the following steps: separating 18 bifidobacterium strains from feces of children aged 0-3 years old, analyzing and identifying the 18 bifidobacterium strains including bifidobacterium longum, bifidobacterium breve and bifidobacterium animalis, and screening out the bifidobacterium breve LE4 with potential Alzheimer's disease relieving capacity through in-vitro oxidation resistance and LPS (Lipopolysaccharide) removal capacity. The method comprises the steps of behavioral experiments (nesting experiments, open field experiments and water maze experiments), histopathologic analysis, molecular biological detection and the like. The multi-target AD intervention effects of improving the cognitive function, reducing A beta deposition and tau protein phosphorylation, relieving neuroinflammation, enhancing synaptic plasticity, repairing intestinal barriers, adjusting intestinal flora and metabolites and the like of the LE4 strain are comprehensively evaluated, and a new strategy is provided for promoting AD micro-ecological treatment.

The present application provides: a microorganism with enhanced lipoate protein ligase activity; a composition for producing histidine comprising the microorganism; and a method for producing histidine, the method comprising a step for culturing the microorganism.

The present invention provides a strain of the genus Alistipes as well as a pharmaceutical composition comprising the strain or an extract of the strain. The strain and the pharmaceutical composition disclosed by the invention can be used for remarkably relieving such symptoms as weight loss, shortened colon length, inflammatory factor release and the like of an enteritis object, and do not have toxic or side effects. Therefore, the another mycobacterium strain or the active extract of the another mycobacterium strain can be used for preparing pharmaceutical compositions and fermented foods for relieving enteritis, and has a very wide application prospect.

The present application relates to a Corynebacterium sp. microorganism in which a foreign nicotinamide nucleotide transhydrogenase protein is expressed or a polynucleotide encoding the same is introduced, whereby the microorganism exhibits improved production capability of L-amino acids or derivatives thereof.

The present application relates to: a culture medium composition for microorganisms of Corynebacterium species, in which part of ammonium sulfate is replaced with a different ammonium-containing compound; and a method for producing a basic amino acid by using the culture medium composition.

This disclosure relates to compositions and methods using genetically modified bacteria that express superoxide dismutase (SOD) and catalase enzymes to reduce oxidative stress in the skin, and can be used for various skin conditions. In some embodiments of this disclosure, the genetically modified bacteria are Gram-positive bacteria, for example, of the genus Corynebacterium.

The invention discloses a composite ecological restoration technology suitable for an open-pit coal mine waste dump. The technology comprises the following steps: (I) planting water-saving and convergence-increasing plants: sowing the water-saving and convergence-increasing plants to the open-pit coal mine waste dump to be restored in a shrub and grass seed broadcast sowing manner; (II) preparation and spraying of a prokaryotic microbial strain: culturing the separated and purified pseudoarthrobacter sp.xwn1, microbacterium sp.xwn2 and Acinetobacter sp.xwp1, carrying out enlarged culture on the cultured microbial agent, and then spraying and applying the microbial agent to the open pit coal mine waste dump after the microbial agent is applied to the open pit coal mine waste dump after the microbial agent is applied to the open pit coal mine waste dump after the microbial agent is applied to the open pit coal mine. By using the composite ecological restoration technology, the carbon sequestration capacity of plants is promoted, the organic carbon content of soil is increased, and ecological carbon sequestration restoration of the open pit coal mine waste dump is facilitated.

Provides *Parabacterium* strains, cultures, inoculants, and their applications. Specifically, provides a *Parabacterium* strain, which may be a strain with accession number GDMCC No: 62664 or 62665, or a strain with at least 96.74% identity to the strain's 16S rRNA and / or at least 87% average nucleotide identity to the strain's genome; the strain or products based on the strain have good preventive or therapeutic effects on tumors or cancers, metabolic diseases, inflammatory or autoimmune diseases, infectious diseases, and central nervous system diseases.

The present invention provides a prophylactic or therapeutic composition for graft-versus-host disease (GVHD). There is provided a prophylactic or therapeutic composition for GVHD, which comprises bacteria belonging to any genus selected from the group consisting of the following genera: Blautia, Clostridium, unclassified Clostridiales, Actinomyces, Parabacteroides, Lachnoclostridium, Bacteroides, Faecalibacterium, unclassified Lachnospiraceae, Roseburia, Ruminococcus, unclassified Firmicutes, Dorea, Phascolarctobacterium, Sutterella, Megamonas, Collinsella, Eubacterium, and Coprococcus, etc., or any combination of bacteria belonging to these genera.

The present invention relates to an antibacterial or antifungal composition and a pharmaceutical composition for preventing or treating bacterial or fungal infections, both comprising VLX600. The antibacterial composition comprising VLX600 according to one aspect of the present invention exhibits antibacterial or antifungal activity against a wide range of strains, including Mycobacterium spp., Escherichia spp., Pseudomonas spp., Staphylococcus spp., Acinetobacter spp., Candida spp., and the like. The pharmaceutical composition comprising VLX600 demonstrates excellent antibacterial, antifungal, and therapeutic efficacy against pathogens and can be effectively utilized for the prevention or treatment of bacterial or fungal infections. Furthermore, VLX600 exhibits a synergistic effect with conventional antibiotics and thus is effective in treating infections caused by antibiotic-resistant bacterial strains.

The present invention addresses the problem of providing a novel functionality of a Bifidobacterium longum subsp. Infantis M-63 (NITE BP-02623), and a method for producing the same, and more particularly, to provide a novel functionality of a Bifidobacterium longum subsp. Infantis M-63 (NITE BP-02623). A composition to be ingested by healthy neonates or infants who are born for a full month contains, as an active ingredient, one or more species selected from the group consisting of a cell of Bifidobacterium longum subsp. Infantis M-63 (NITE BP-02623), a culture of the cell, and a treated product of the cell. The composition is used for promoting colonization of bifidobacterium bacteria in intestinal flora, promoting maturation of intestinal function, inhibiting milk spilling or regulating immune function.

A composition of oral administration for use in the prevention or and treatment degenerative diseases of the eye that it comprises lysates of probiotic micro-organisms in the form of a dry powder of the genus Bacillus, Lactobacillus, Streptococcus, Saccharomyces and Bifidobacterium.

The present disclosure relates to: a protein variant; a polynucleotide encoding the protein variant; a Corynebacterium genus microorganism comprising at least one selected from the group consisting of the protein variant and the polynucleotide; and a method for producing L-isoleucine using the microorganism.

The application discloses a Limosilactobacillus reuteri strain capable of improving selenoenzyme activity and high in selenium selenocysteine, and belongs to the technical field of microorganisms.The Limosilactobacillus reuteri CCFM1303 screened by the application can efficiently enrich inorganic selenium and convert the inorganic selenium into organic selenium (selenium selenocysteine), which can be better absorbed and utilized by a body, and effectively improve selenoenzyme activity of the body.Animal experiments prove that the selenium-rich Limosilactobacillus reuteri can improve selenoenzyme activity in male mice, has higher biological activity than inorganic selenium, and meets physiological requirements of selenium supplement.The Limosilactobacillus reuteri CCFM1303 of the application can efficiently enrich inorganic selenium, produce selenium selenocysteine, and be used for preparing probiotic preparations for improving selenoenzyme activity of a body, and has great application prospects in the fields of food and medicine.

The invention belongs to the technical field of biomedicine, and particularly relates to a flora marker for predicting colorectal cancer liver metastasis and application of the flora marker. According to the present invention, the bacterial group marker is the combination of Acinetobacter, Streptococcus, Pseudomonas, Brevundimonas and Sphingomonas, and the bacterial group marker combination provides extremely high specificity (95.29%) and sensitivity (91.43%) when the early liver metastasis of colorectal cancer is predicted, such that the liver metastasis risk of the patient can be accurately assisted in the determination, and the early liver metastasis risk of the colorectal cancer can be accurately determined; the method has the advantages that reliable basis is provided for clinical decision making, the colorectal cancer liver metastasis can be predicted only by taking the abundance of the specific bacteria as an input index, the method is not limited by specific measurement means, and dependence on a detection technology is greatly reduced.

To provide a soil microbiota improving agent, a method for preparing a soil microbiota improving agent, and a method for improving soil microbiota, employing a Lysobacter bacterium unused in conventional microbial pesticides or microbial formulations as a novel microbial resource.MEANS FOR SOLVING THE PROBLEM: The foregoing problem is solved by a soil microbiota improving agent comprising a Lysobacter bacterium or a bacterial flora comprising a Lysobacter bacterium.SELECTED DRAWING: None

The invention belongs to the technical field of microorganisms, and particularly relates to a novel strain of brevibacterium and application thereof. The strain is separated from rapana venosa, is a new species of Brevibacterium, is named as Brevibacterium sp. M-17, is registered and preserved in the China Center for Type Culture Collection (CCTCC), and has the preservation number of CCTCC NO: M 20241860. The Brevibacterium sp. M-17 strain disclosed by the invention has obvious bacteriostatic activity on bacillus subtilis, escherichia coli, shewanella, enterobacter aerogenes, staphylococcus aureus and proteus vulgaris, has obvious antioxidant activity, has alpha-glucosidase inhibitory activity, can generate gelatinase, cellulase and amylase, and can be used for preparing an anti-inflammatory agent. The strain can be applied to preparation of bacteriostatic agents, antioxidants, alpha-glucosidase inhibitors, gelatinase, cellulase and amylase, can also be applied to industrial production instead of the bacteriostatic agents, the antioxidants, the gelatinase, the cellulase and the amylase in a viable bacterium form, and has good development and application prospects.

The present invention relates to the use of a bacterial strain or a combination of bacterial strains in the preparation of a probiotic for fish, said bacterial strains being selected from the following: a Chryseobacterium massiliae strain identified by accession number No. I-5479 deposited at the CNCM on January 24, 2020 and a Flavobacterium sp. strain identified by accession number No. I-5481 deposited at the CNCM on January 24, 2020. The probiotic use includes preventing or minimizing Flavobacterium columnare infection in fish. The present invention also relates to the deposited bacterial strains, or a probiotic composition or kit comprising the same, and a method for identifying a probiotic bacterial strain resistant to pathogen infection.

One embodiment of the present invention provides a promoter which is characterized by comprising a base sequence represented by sequence 6 or a base sequence represented by sequence 27, and which regulates the expression of psicose epimerase in a Corynebacterium strain. The novel promoter provided by the invention can be used for constitutive high expression of a target protein, especially an enzyme, in a corynebacterium strain. For example, when using a recombinant Corynebacterium strain transformed with an expression vector comprising a novel promoter of the present invention, psicose epimerase can be economically mass-produced or psicose can be economically mass-produced from fructose.

A cosmetic treatment method comprising application of a composition comprising at least one antioxidant and a Bifidobacterium spp. lysate. The present invention relates to a method for the cosmetic treatment of the scalp and hair comprising application of a composition comprising at least one specific antioxidant, a Bifidobacterium spp. lysate and water. Preferably, the cosmetic treatment method of the present invention is a method for caring for and / or conditioning the scalp and hair.

The invention relates to the technical field of tag peptides, and particularly discloses a tag peptide combined on the surface of corynebacterium, and the amino acid sequence of the tag peptide is shown as SEQ ID NO: 1 or SEQ ID NO: 2. The tag peptide provided by the invention enriches the types of tag peptides bound to the surfaces of current bacteria, and corynebacterium bacteria bound with the tag peptide have wider adaptability to pH and can be compatible with the optimal activity conditions of more foreign proteins; the molecular weight of the tag peptide is only 3.5 kDa, so that the interference to the structure or function of an exogenous protein can be remarkably reduced; in addition, the tag peptide can be fused at the N end or the C end of the target protein, the binding efficiency is not affected, simultaneous display of multiple proteins is supported, and a basis is provided for multi-enzyme cascade reaction and multivalent vaccine development.

The present invention relates to a Corynebacterium sp. mutant microorganism producing L-glutamic acid and a method of producing L-glutamic acid using the same, and more specifically, to a novel NADP-dependent malic enzyme variant involved in the L-glutamic acid biosynthetic pathway, a polynucleotide, and a transformant, as well as a method of producing L-glutamic acid using the same. The NADP-dependent malic enzyme variant according to the present invention is obtained by substituting one or more amino acids in the amino acid sequence constituting NADP-dependent malic enzyme to change the enzymatic activity of the NADP-dependent malic enzyme, and a recombinant microorganism comprising the NADP-dependent malic enzyme variant is capable of efficiently producing L-glutamic acid.

The invention relates to a microbial agent for removing refractory COD (Chemical Oxygen Demand) in wastewater and application of the microbial agent, and belongs to the technical field of biological purification. The invention provides a microbial agent for removing refractory COD (Chemical Oxygen Demand) in wastewater. The microbial agent is prepared from two or more of geomonas, rope warming bacteria, nitro-spirillum, thiobacillus, urea bacillus, leptospirillum, piriformospora, floating fungi, nitro-spina bacteria, thauera and hyphomicrobe. The microbial agent can remove part of refractory COD (Chemical Oxygen Demand) by utilizing the synergistic effect and co-metabolism of biocenosis, and has a great application prospect in the treatment of wastewater (such as landfill leachate and the like) containing a large amount of refractory COD.

The present invention relates to microbial based compositions comprising Methylobacterium species for improving plant growth and productivity.

The present invention relates to a Corynebacterium sp. mutant microorganism producing L-glutamic acid and a method of producing L-glutamic acid using the same, and more specifically, to a novel malate:quinone oxidoreductase variant involved in the L-glutamic acid biosynthetic pathway, a polynucleotide, and a transformant, as well as a method of producing L-glutamic acid using the same. The malate:quinone oxidoreductase variant according to the present invention is obtained by substituting one or more amino acids in the amino acid sequence constituting malate:quinone oxidoreductase to change the enzymatic activity of the malate:quinone oxidoreductase, and a recombinant microorganism comprising the malate:quinone oxidoreductase variant is capable of efficiently producing L-glutamic acid.

The present disclosure relates to a Corynebacterium sp. microorganism for producing glutamate-based amid acids, and a method for producing glutamate-based amino acids using the microorganism.

The present application relates to a Corynebacterium genus microorganism into which an exogenous soluble pyridine nucleotide transhydrogenase is introduced, and a method for producing L-tryptophan using the same.

The present invention discloses a polycyclic aromatic hydrocarbon-degrading strain regulated by quorum sensing, a screening method, and an application thereof. The polycyclic aromatic hydrocarbon-degrading strain regulated by quorum sensing is Acinetobacter sp. YY-1, with a deposit number of GDMCC No: 63126 and a deposit date of January 9, 2023. The polycyclic aromatic hydrocarbon-degrading strain provided by the present invention has an enhanced ability to degrade polycyclic aromatic hydrocarbons under quorum sensing control and has good application prospects.

The present invention relates to a novel bacterium of the genus Corynebacterium, useful for cosmetic application. A method for screening anti-aging substances is also provided.