Composition for degrading opioid peptide

A technology of opioid peptides and compositions, applied in the field of opioid peptide decomposing agents or opioid peptide decomposing compositions, to achieve the effect of less side effects

Pending Publication Date: 2020-10-16
MORINAGA MILK IND CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, up to now, there has not been any report that bacteria of the genus Bifidobacterium, cultures of the aforementioned bacteria, and cell-treated substances of the aforementioned bacteria have an action of decomposing opioid peptides

Method used

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  • Composition for degrading opioid peptide
  • Composition for degrading opioid peptide
  • Composition for degrading opioid peptide

Examples

Experimental program
Comparison scheme
Effect test

manufacture example 1

[0206] One or more of the 17 kinds of Bifidobacteria bacteria used in Test Example 1 were added or added to 3 mL of the same MRS liquid medium, and anaerobic culture was carried out at 37 ° C for 16 hours, and the culture solution Concentrate and freeze-dry to obtain the end of one or more bacteria. The powder of one or more fungi is mixed with excipients and the like to form a tablet. The intake of bacteria in total is 1×10 6 ~1×10 12 The tablet was ingested daily for 3 months in the form of cfu / kg body weight / day.

[0207] The opioid peptide decomposition effect can be expected by ingestion of this tablet.

manufacture example 2

[0209] One or more of the 17 kinds of Bifidobacterium bacteria used in Test Example 1 were added or added to 3 mL of the same MRS liquid medium, and anaerobic culture was carried out at 37 ° C for 16 hours, and the culture solution was concentrated. Freeze-drying is carried out to obtain the end of one or more bacteria. Fermented milk was obtained by adding the one or more types of powdered bacteria to fermented milk raw materials. The intake of bacteria in total is 1×10 6 ~1×10 12 The fermented milk was ingested every day for at least 3 months in the form of cfu / kg body weight / day.

[0210] The opioid peptide decomposition effect can be expected by ingestion of this fermented milk.

manufacture example 3

[0212] The manufacturing method of the formula milk powder which added 1 or more types of bacteria selected from the 17 types of Bifidobacterium genus bacteria used in Test Example 1 is shown below.

[0213] Desalted milk whey protein powder (manufactured by Mirai Co., Ltd.) 10 kg, milk casein powder (manufactured by Fonterra Co., Ltd.) 6 kg, lactose (manufactured by Mirai Co., Ltd.) 48 kg, mineral mixture (manufactured by Tomita Pharmaceutical Co., Ltd.) 920 g, vitamin mixture (manufactured by Tanabe Pharmaceutical Co., Ltd.) Dissolve 32 g of lactulose (manufactured by Morinaga Dairy Co., Ltd.), 500 g of raffinose (manufactured by Nippon Beet Sugar Manufacturing Co., Ltd.), and 900 g of galactooligosaccharide liquid sugar (manufactured by Yakult Pharmaceutical Industry Co., Ltd.) In 300 kg of warm water, it was heated and dissolved at 90° C. for 10 minutes, and 28 kg of prepared fat (manufactured by Sun Oil Co., Ltd.) was added and homogenized. Then, sterilizing, concentratin...

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PUM

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Abstract

The present invention addresses the problem of providing an agent for degrading an opioid peptide or a composition for degrading an opioid peptide which requires no restriction on diet, shows no sideeffects even if used regularly and, therefore, can be continuously used free from anxiety. To solve this problem, provided are an agent for degrading an opioid peptide, a composition for degrading anopioid peptide, a medicinal composition for degrading an opioid peptide and a food or beverage composition for degrading an opioid peptide, each comprising, as an active ingredient, a bacterium belonging to the genus Bifidobacterium, a culture of the bacterium and / or treated cells of the bacterium.

Description

technical field [0001] The present invention relates to an opioid peptide decomposing agent, a composition for decomposing opioid peptides, a pharmaceutical composition for decomposing opioid peptides, and a food and drink composition for decomposing opioid peptides. Background technique [0002] Among the peptides, there are opioid peptides that bind to opioid receptors and exhibit various physiological activities. As opioid peptides, opioid peptides derived from foods are also known to exist in large quantities. For example, in the human digestive tract, a milk-derived opioid peptide called β-casomorphin is produced from casein, which is a milk protein. The aforementioned opioid peptides are known to have various adverse effects on living bodies when they are not decomposed in the digestive tract. For example, it is known that food-derived opioid peptides act on intestinal cells to inhibit the absorption of cysteine ​​and lower the antioxidant capacity (Non-Patent Documen...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/745A23L33/135A61P25/00A61P43/00C12N1/00C12N1/20
CPCA23L33/135A61K35/745A61P25/00A61P43/00C12N1/00C12N1/20A23L33/40A23V2002/00A23V2400/513A23V2400/515A23V2400/517A23V2400/519A23V2400/525A23V2400/533A23V2400/535
Inventor 樱井琢磨桥仓那波清水金忠山田明男
Owner MORINAGA MILK IND CO LTD
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