Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Medicine prepared from neferine, capsaicin and 6-gingerol and used for inhibiting benign prostatic hyperplasia and application

A technology of liensinine and benign prostatic hyperplasia, which is applied in the field of biomedicine, can solve the problems of less therapeutic drugs and less research, and achieve the effect of improving local microcirculation

Pending Publication Date: 2022-02-15
YICHUN UNIVERSITY
View PDF6 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is less research in this area, and fewer therapeutic drugs have been developed

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Medicine prepared from neferine, capsaicin and 6-gingerol and used for inhibiting benign prostatic hyperplasia and application
  • Medicine prepared from neferine, capsaicin and 6-gingerol and used for inhibiting benign prostatic hyperplasia and application
  • Medicine prepared from neferine, capsaicin and 6-gingerol and used for inhibiting benign prostatic hyperplasia and application

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0026] Experimental Example 1 Anti-Prostate Cell Proliferation

[0027] The purpose of this experiment example is to verify that capsaicin 10 μM, 100 μM, 10 μM, 100 μM of liensinine, 10 μM, 100 μM of 6-gingerol have anti-proliferative effects on prostate cells through cell experiments. All drugs were dissolved in dimethyl sulfoxide solution and added to the culture medium, the concentration of dimethyl sulfoxide solution was lower than 0.1%, v / v. Human prostate epithelial cell line LNCaP and human normal prostate stromal cells WPMY-1 were cultured in a 96-well plate with appropriate cell culture medium at 37°C in 5% CO 2 Incubate for about 48 hours under the same conditions, and add drugs after the cells attach and grow on the culture plate. LNCaP cells were incubated in RPMI-1640 medium, and WPMY-1 cells were incubated in DMEM medium.

[0028] The drug addition experiments were divided into 9 groups: (1) control group, containing only the medium and corresponding cells, wit...

experiment example 2

[0035] Experimental Example 2 Proliferation of Prostate Cells Induced by Antiandrogen

[0036] The purpose of this experiment example is to verify that capsaicin 10 μM, 100 μM, 10 μM, 100 μM of liensinine, 10 μM, 100 μM of 6-gingerol have anti-proliferative effects on prostate cells through cell experiments. All the drugs were dissolved in dimethyl sulfoxide solution and added to the culture medium, the concentration of dimethyl sulfoxide solution was lower than 0.1%, v / v. Human prostate epithelial cell line LNCaP and human normal prostate stromal cells WPMY-1 were cultured in a 96-well plate with appropriate cell culture medium at 37°C in 5% CO 2 Incubate for about 48 hours under the same conditions, and add drugs after the cells attach and grow on the culture plate. LNCaP cells were incubated in RPMI-1640 medium, and WPMY-1 cells were incubated in DMEM medium. It should be noted that when the above drugs are added, the stock solution is first prepared at a concentration eq...

experiment example 3

[0044] Experimental example 3 Antiandrogen induces expression of 5α-reductase and PSA protein in prostate epithelial cells

[0045] In the process of benign prostatic hyperplasia, 5α-reductase converts testosterone into more active dihydrotestosterone, and if the expression of 5α-reductase is effectively reduced, it can inhibit the proliferation of prostate cells. According to the experimental method of Example 1, capsaicin (10 μM, 100 μM), liensinine (10 μM, 100 μM), 6-gingerol (10 μM, 100 μM), and liensinine (100 μM) were combined with 6-gingerol ( 100 μM) and capsaicin (100 μM) acted on LNCaP cells, extracted cell protein 24 hours later, detected the expression of 5α-reductase and PSA protein in the cells, and evaluated the effect of the compound on inhibiting androgen-induced prostate cell proliferation by regulating the expression of the two proteins.

[0046] figure 1 It is the protein level expression diagram of 5α-reductase and PSA protein after prostate epithelial ce...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention belongs to the technical field of biological medicines, and particularly relates to a medicine prepared from neensinine, capsaicin and 6-gingerol and used for inhibiting benign prostatic hyperplasia and application. The medicine for inhibiting benign prostatic hyperplasia comprises one or a combination of more of capsaicin, neferine and 6-gingerol. The capsaicin can inhibit the growth of prostate epithelial cells, various cancer cells show an anti-hyperplasia effect, the neferine can be used as a 5[alpha]-reductase to inhibit and further resist prostatic hyperplasia / hypertrophy, and the 6-gingerol is one of active ingredients extracted from the ginger, and has the pharmacological effects of resisting oxidation, reducing blood fat, diminishing inflammation and resisting hyperplasia. The medicine is used for treating prostatic diseases through pharmacology of eliminating benign prostatic hyperplasia, resisting inflammation and improving local microcirculation, and can also be used for preparing medicines, health-care foods or food additives.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and in particular relates to a medicine for inhibiting benign prostatic hyperplasia prepared by methyl liensinine, capsaicin and 6-gingerol and its application. Background technique [0002] Benign prostatic hyperplasia is a common male urinary tract disease characterized by hyperplasia of the prostate gland and smooth muscle. It can lead to compression of the urethra in patients, resulting in symptoms of urinary retention and urinary tract infection. Predilection occurs in middle-aged men over the age of 50, and its incidence rate increases year by year with the increase of the elderly population. The cause of benign prostatic hyperplasia is related to androgen imbalance, and androgen causes benign prostatic hyperplasia through androgen receptors and interference signaling pathways. [0003] Clinically, surgery and drugs are used to treat symptoms caused by benign prostatic hyperplasia. T...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K31/4725A23L33/10A23L33/105A61P13/08A61K31/12A61K31/165
CPCA61K31/165A61K31/4725A61K31/12A61P13/08A23L33/10A23L33/105A23V2002/00A61K2300/00A23V2200/30A23V2250/21
Inventor 刘棋铭邵子辰吴正平
Owner YICHUN UNIVERSITY
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com