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Method and system for treating obesity-related diseases by oral active AdipoRon

An active, type 2 diabetes technology, applied in metabolic diseases, pharmaceutical formulations, drug delivery, etc., can solve the problem of high cost of β-cell gene knockout mice, and achieve good popularization and feasibility.

Pending Publication Date: 2022-02-22
WENZHOU MEDICAL UNIV
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Problems solved by technology

[0008] The present invention overcomes the high cost problem of β-cell gene knockout mice by constructing a type II diabetes mouse model, and measures the expression of GLUT4 mRNA in C2C12 cells; comprehensively detects the influence of oral active AdipoRon on the PI3K / Akt signaling pathway

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  • Method and system for treating obesity-related diseases by oral active AdipoRon

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Experimental program
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Embodiment Construction

[0009] 1. Preparation and grouping of type II diabetes mouse model

[0010] 40 12-week-old male C57BL / 6 mice (purchased from Shanghai Experimental Animal Center, Chinese Academy of Sciences), 40 SPF male C57 / BL6 mice (adaptive feeding for 1 week, randomly divided into 10 normal control NC groups) With 30 of the experimental group, the NC group was given conventional feed, and the experimental group was fed with high-sugar and high-fat diet (66.5%+20% brown sugar+10% lard+2.5% cholesterol+1% bile salt of conventional feed). After 5 weeks , fasting for 12 hours, intraperitoneally injecting 1% streptozotocin 40mg / kg to induce diabetes model, fasting for 4 hours after 72 hours, taking blood from the tail to measure FPG. Blood glucose concentration> 11mmol / L, and polydipsia, polyphagia, polyphagia The urinary symptoms suggested that the diabetic mouse model was successfully induced. Treatment once a day: the mice in the DM+L group were fed with AdipoRon at a dose of 1.25 mg / kg; the...

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Abstract

The research is different from other previous researches, and the action mechanism of the AdipoRon for treating the type 2 diabetes mellitus is discussed by applying a biological method. Liver cells are taken as experimental subjects, an experimental group for blocking a P13 / Akt signal channel is constructed, then AdipoRon is given, expression of saccharide genes related to the liver cells is analyzed, and the cellular mechanism of the AdipoRon for treating type 2 diabetes mellitus is discussed. At present, the research is not reported at home and abroad. The current method for treating the type 2 diabetes mellitus almost needs reasonable diet and exercise, and generates adverse effects such as hypoglycemia and weight gain, and the excessive caloric intake can be safely reduced by orally taking the AdipoRon, and the consequence caused by the lifestyle of sedentariness can be relieved, so that the AdipoRon provides a novel treatment method. By using the method, lots of expenditures for purchasing db / db mice and double-gene knockout mice can be saved.

Description

technical field [0001] The field of oral active AdipoRon for the treatment of obesity-related diseases (such as type 2 diabetes), especially relates to the feasibility of verifying AdipoRon (an adiponectin receptor activity activator) for the treatment of type 2 diabetes. Background technique [0002] Studies have shown that diabetes has become an endocrine and metabolic disease that seriously threatens human health. Type II diabetes accounts for more than 95% of diabetic patients. The risk of malignant tumors such as colorectal cancer, liver cancer, and breast cancer in patients with type II diabetes is significantly higher than that of the general population. Insulin resistance is a common cause of diseases such as type II diabetes and cardiovascular disease in obese and susceptible individuals. [0003] At present, the drugs for the treatment of type II diabetes are mainly oral hypoglycemic drugs, but they are often accompanied by some serious adverse reactions, such as...

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Application Information

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IPC IPC(8): A61K9/00A61K45/00A61P3/10A61P3/04
CPCA61K9/0053A61K45/00A61P3/10A61P3/04
Inventor 肖敏
Owner WENZHOU MEDICAL UNIV
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