Magnetic nanoparticle temperature measurement method based on electron paramagnetic resonance integral spectrum full width at half maximum
A technology of electron paramagnetic resonance and magnetic nanoparticles, which is applied in the direction of thermometers using electric/magnetic elements that are directly sensitive to heat, using electromagnetic means, thermometers, etc., to achieve high-precision temperature measurement, improve temperature measurement resolution, and broaden the temperature range. The effect of the application scene
Active Publication Date: 2022-03-01
HUAZHONG UNIV OF SCI & TECH
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[0005]
Since the human body is "magnetically transparent", the excellent magnetic-temperature properties of magnetic nanoparticles provide a possible solution for visual temperature imaging inside the living body, but high-resolution temperature imaging still faces great challenges.
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[0051] 1. Simulation model and test description:
[0052] In order to study the feasibility of the temperature measurement method of magnetic nanoparticles based on electron paramagnetic resonance, this example simulates the electron paramagnetic resonance signal of magnetic nanoparticles. The simulation parameters are: particle size D=15nm, main magnetic field scanning range is 76-576mT, microwave frequency v=9.141GHz, and simulation temperature is 30°C. gain
[0053] 2. Simulation test results:
[0054] figure 2 It reflects the electron paramagnetic resonance spectrum and integral spectrum of magnetic nanoparticles with a particle size of 15nm. It can be seen from the figure that there is only one resonance peak.
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Abstract
The invention belongs to the technical field of nanometer material testing, and particularly relates to a magnetic nanoparticle temperature measurement method based on electron paramagnetic resonance integral spectrum full-width-at-half-maximum, which comprises the following steps: measuring a paramagnetic resonance wave spectrum of a magnetic nanoparticle liquid sample, carrying out integration to obtain an integral spectrum, then extracting full-width-at-half-maximum information, and carrying out temperature measurement according to the change of the full-width-at-half-maximum. A temperature measurement model representing the relation between the full width at half maximum and the temperature is obtained through an experiment, and then the temperature is obtained through calculation according to full width at half maximum information of a sample to be measured. The magnetic nanoparticles have superparamagnetism, and the resonance spectrum of the magnetic nanoparticles can be easily obtained by using electron paramagnetic resonance equipment. Research finds that under the condition that particle size distribution of particles is fixed, spectrum full-width-at-half-maximum change after integration is only related to temperature, concentration change does not influence the spectrum full-width-at-half-maximum change, influence caused by system noise can be partially reduced through integration operation, temperature measurement is more accurate, and therefore the method can be well suitable for life medicine and has good application prospects. And in-vivo non-intrusive temperature measurement is carried out.
Description
technical field [0001] The invention belongs to the technical field of nanomaterial testing, and more specifically relates to a method for measuring temperature of magnetic nanoparticles based on the full width at half maximum of electron paramagnetic resonance integral spectrum. Background technique [0002] Temperature is an important indicator of life activities. In the field of life sciences, imaging the temperature distribution of living cells is an important challenge for scientists. Sensing "thermal events" at the cellular level helps to grasp the energy changes in the process of cell metabolism, which is of great significance for drug targeting and tumor hyperthermia. However, due to the "closed nature" of living organisms, how to sense and measure these "thermal events" non-invasively and accurately has become a frontier topic and a key challenge in life medicine. [0003] In recent years, the magnetic temperature measurement method has been considered as one of t...
Claims
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Login to View More IPC IPC(8): G01K7/36
CPCG01K7/36
Inventor 刘文中王帅
Owner HUAZHONG UNIV OF SCI & TECH
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