Unlock instant, AI-driven research and patent intelligence for your innovation.

Hydrogel patch and preparation method thereof

A technology of hydrogel patch and deionized water, which is applied in the direction of pharmaceutical formula, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., which can solve the problem of difficulty in ensuring the quality of patch production, different production cycles, etc. question

Pending Publication Date: 2022-04-12
钱峙涛
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] In order to solve the above problems and overcome the deficiencies of the prior art, the present invention provides a hydrogel patch and a preparation method, which can effectively solve the problem that it is difficult to ensure the production quality of the patch due to different production cycles by controlling the curing time

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Hydrogel patch and preparation method thereof
  • Hydrogel patch and preparation method thereof
  • Hydrogel patch and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] The hydrogel patch is characterized in that it includes: A component, B component and C component, the A component includes partially neutralized sodium polyacrylate and glycerin, and the B component includes aziridine and deionized Water, component C is chondroitin sulfate.

[0028] Further, the mass parts of the A component, the B component and the C component are: 13:100:0.1.

[0029] Further, the mass fraction of partially neutralized sodium polyacrylate and glycerin in the A component is: 3:10; the mass fraction of the B component aziridine and deionized water is: 0.01:100.

[0030] A preparation method of a hydrogel patch, preparing the hydrogel patch:

[0031] (1) Disperse part of the neutralized sodium polyacrylate in glycerin according to the preset ratio, and mix evenly until there are no lumps;

[0032] (2) dissolving aziridine in water according to the preset ratio;

[0033] (3) disperse component C in phase A of step (1) according to the preset proportio...

Embodiment 2

[0037] The hydrogel patch is characterized in that it includes: A component, B component and C component, the A component includes partially neutralized sodium polyacrylate and glycerin, and the B component includes aziridine and deionized Water, component C is chondroitin sulfate.

[0038] Further, the mass parts of the A component, the B component and the C component are: 50:100:10.

[0039] Further, the mass fraction of partially neutralized sodium polyacrylate and glycerin in the A component is: 10:40; the mass fraction of the B component aziridine and deionized water is: 5:100.

[0040] A preparation method of a hydrogel patch, preparing the hydrogel patch:

[0041] (1) Disperse part of the neutralized sodium polyacrylate in glycerin according to the preset ratio, and mix evenly until there are no lumps;

[0042] (2) dissolving aziridine in water according to the preset ratio;

[0043] (3) disperse component C in phase A of step (1) according to the preset proportion; ...

Embodiment 3

[0047] The hydrogel patch is characterized in that it includes: A component, B component and C component, the A component includes partially neutralized sodium polyacrylate and glycerin, and the B component includes aziridine and deionized Water, component C is chondroitin sulfate.

[0048] Further, the mass parts of the A component, the B component and the C component are: 30:100:3.

[0049] Further, the mass fraction of partially neutralized sodium polyacrylate and glycerin in the A component is: 5:25; the mass fraction of the B component aziridine and deionized water is: 0.3:100.

[0050] A preparation method of a hydrogel patch, preparing the hydrogel patch:

[0051] (1) Disperse part of the neutralized sodium polyacrylate in glycerin according to the preset ratio, and mix evenly until there are no lumps;

[0052] (2) dissolving aziridine in water according to the preset ratio;

[0053] (3) disperse component C in phase A of step (1) according to the preset proportion; ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a hydrogel patch and a preparation method, and belongs to the technical field of gel patches, the hydrogel patch comprises a component A, a component B and a component C. The component A comprises partially neutralized sodium polyacrylate and glycerin, the component B comprises aziridine and deionized water, and the component C is a bioactive substance; the coating temperature is controlled to be 40-60 DEG C, coating is carried out, the coating temperature is 48 DEG C, and the coating speed is 6 m / min. The method has the beneficial effects that aziridine has the characteristic of curing threshold temperature for the hydrogel patch, that is, as long as the curing threshold temperature of aziridine is not reached, the time is prolonged and the temperature is increased to a certain extent, the hydrogel added with the cross-linking agent aziridine is very difficult to quickly cure; the characteristic is creatively applied to the preparation of the hydrogel patch, the production requirement can be just met, and due to the existence of the curing threshold temperature of aziridine, the rapid curing of the hydrogel can be realized by selectively activating the curing threshold temperature at a proper process time node.

Description

Technical field: [0001] The invention belongs to the technical field of gel patches, and more specifically relates to a hydrogel patch and a preparation method thereof. Background technique: [0002] Gel plasters (gel plasters), formerly known as cataplasms (referred to as cataplasms), refer to extracts, decoction pieces or (and) chemical drugs mixed with a suitable hydrophilic matrix, and then coated on the backing material Made plasters. Commonly used substrates are sodium polyacrylate, sodium carboxymethylcellulose, gelatin, glycerin and micronized silica gel. [0003] The main features include: ①Good biocompatibility with the skin, the hydrophilic polymer matrix has air permeability, sweat resistance, non-sensitization and non-irritating; ②Large drug loading, especially suitable for traditional Chinese medicine extracts; ③ Good drug release performance, strong affinity with the skin, can improve the hydration of the stratum corneum, and facilitate the transdermal absor...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K9/70A61K31/737A61K47/10A61K47/22A61K47/32
CPCY02A50/30
Inventor 钱峙涛
Owner 钱峙涛