Copolymer solution as well as preparation method and application thereof

A technology of copolymers and enol copolymers, which can be used in drug combination, drug delivery, pharmaceutical formulations, etc., can solve problems such as the reduction of the validity period of povidone-iodine solution disinfection effect, reduce the consistency and risk of agglomeration, extend the validity period, and extend the The effect of storage time

Pending Publication Date: 2022-04-12
成都科宏达科技有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These technical problems will lead to the reduction of the effective period of disinfection effect of povidone-iodine solution

Method used

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  • Copolymer solution as well as preparation method and application thereof
  • Copolymer solution as well as preparation method and application thereof
  • Copolymer solution as well as preparation method and application thereof

Examples

Experimental program
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preparation example Construction

[0046] In the second aspect, the embodiment of the present invention provides a method for preparing the copolymer solution described in the first aspect, comprising the following steps:

[0047] (1) Under stirring conditions, add the vinylpyrrolidone-enol copolymer solution, the solvent, the iodine, and the co-solvent in sequence, mix evenly, heat up to 40-60°C, and keep warm for 2-5 hours ,spare;

[0048] (2) Use a pH regulator to adjust the pH of the mixed system prepared in the above step (1) to 3 to 6, then add the stabilizer and the dispersant, replenish water to 100 parts, and stir for 0.5 to 1 hour to obtain the final product The copolymer solution.

[0049] In the method provided in this example, the vinylpyrrolidone-enol copolymer solution is directly used for preparation, eliminating the need for post-treatment processes such as extraction and purification of the vinylpyrrolidone-enol copolymer, and the preparation of the copolymer solution directly uses all the i...

preparation example 11

[0054] The reaction molar ratio of each raw material is: N-vinylpyrrolidone: vinyl acetate: initiator AIBN: dehydrated alcohol: phosphoric acid=1:1:0.01:4:0.02.

[0055] Using absolute ethanol as a solvent, add N-vinylpyrrolidone (NVP) and vinyl acetate into a three-necked flask equipped with a mechanical stirring device, blow in nitrogen, and stir. Add the initiator AIBN when the temperature rises to 76°C, slowly add the remaining mixed solution of the two monomers and ethanol dropwise during the reaction, and add the remaining AIBN, react for 8 hours and then heat up to 80°C for 3 hours, and keep the sample And recorded as the intermediate sample No. 1. Phosphoric acid was added to the remaining reaction solution to treat it for 8 hours, and the reaction was stopped to obtain a vinylpyrrolidone-enol copolymer solution. To facilitate the description of subsequent examples, the vinylpyrrolidone-enol copolymer solution prepared in this step is referred to as stock solution No....

preparation example 12

[0057] The reaction molar ratio of each raw material is: N-vinylpyrrolidone: vinyl acetate: initiator AIBN: dehydrated alcohol: phosphoric acid=3:1:0.04:12:0.2.

[0058] The preparation process is similar to that of Preparation Example 1.1, with the difference that: the temperature of the copolymerization reaction is kept at 60°C; the temperature of the acid treatment is kept at 70°C, and the reaction time is 4h. To facilitate the description of subsequent examples, the vinylpyrrolidone-enol copolymer solution prepared in this step is designated as stock solution No. 2, and the remaining intermediate sample that has not been subjected to acid treatment is designated as intermediate sample No. 2.

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Abstract

The invention provides a copolymer solution as well as a preparation method and application thereof. The copolymer solution comprises 15%-30% of a vinyl pyrrolidone-enol copolymer solution, 10%-15% of iodine, 25%-35% of a solvent, 0.5%-3% of a cosolvent, 0.75%-1.5% of a pH regulator, 0.5%-5% of a dispersant and 0%-0.3% of a stabilizer. Wherein the vinyl pyrrolidone-enol copolymer solution is a reaction liquid system which is obtained by taking vinyl pyrrolidone and C4-20 straight-chain or branched-chain alpha-olefin acetate as reactants and carrying out acidizing treatment on the basis of completing a polymerization reaction. The vinyl pyrrolidone-enol copolymer solution is used for replacing polyvinylpyrrolidone, so that the problem of complexing stability with iodine is solved, the storage time of iodine content is prolonged, the pH value of a solution system is not continuously reduced in the storage process, and the consistency and agglomeration risk of the solution are reduced; furthermore, iodine can be completely and stably complexed with the copolymer for a long time, so that the purpose of prolonging the validity period of the disinfection effect is achieved.

Description

technical field [0001] The application relates to the field of disinfection preparations, in particular to a copolymer solution and its preparation method and application. Background technique [0002] Povidone-iodine solution has broad antibacterial activity and has a killing effect on bacteria, fungi, protozoa and viruses. As a broad-spectrum antibacterial agent, it is widely used in the prevention and treatment of local wound infections, such as first aid for minor cuts, abrasions, burns, and blisters. The mechanism of action of the povidone solution is that after the solution contacts the wound or affected area, it can depolymerize and release free iodine to play a bactericidal effect, and at the same time, it is relatively less irritating to tissues. [0003] However, there are many technical problems in the existing povidone-iodine solution. For example, the complexation stability of povidone and iodine in the povidone-iodine solution is poor, and the iodine content ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/79A61K9/08A61K47/10A61P17/00A61P17/02A61P31/02C08F218/08C08F226/10
Inventor 陈佳杨阳杨霆唐宁陈晓阳张豫红
Owner 成都科宏达科技有限公司
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