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Chalcone compound as well as preparation method and application thereof

A compound and hydrate technology, applied in organic chemistry, drug combination, pharmaceutical formula, etc., can solve the problems of extraction, separation and effect research of chalcones that have not yet been seen, and achieve the effect of broad medical application prospects

Pending Publication Date: 2022-04-12
CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] At present, the research on ambrette seeds is mainly focused on the quality standards and component analysis research, which involves the extraction and separation of a small amount of chemical components, and only a small amount of research on the content determination of amino acids, nucleosides and fatty acids. There is less literature on the structure
The extraction, separation and effect research of the chalcones compound of the present invention have not yet been seen

Method used

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  • Chalcone compound as well as preparation method and application thereof
  • Chalcone compound as well as preparation method and application thereof
  • Chalcone compound as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
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Embodiment 1

[0052] Embodiment 1, the present invention extracts and isolates the method for new compound from the ambrette seed

[0053] The present invention extracts and separates the method for novel compound from the ambrette seed and comprises the following steps:

[0054] Step 1: Take 10 kg of dried medicinal materials of Ambrette seeds, pulverize them, reflux extract with 8 times the amount of 85% ethanol for 3 times, each time for 2 hours, combine the filtrates and concentrate under reduced pressure to obtain an extract.

[0055] Step 2: Suspend the extract in water and extract it with equal volume of ethyl acetate for 3 times, combine the extracts to obtain the extraction part of ethyl acetate, and concentrate the extraction part of ethyl acetate under reduced pressure with a rotary evaporator to obtain the extract of the part of ethyl acetate 100g.

[0056] Step 3: Put 100g of ethyl acetate part extract through normal phase silica gel column chromatography for separation and el...

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PUM

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Abstract

The invention provides a chalcone compound as well as a preparation method and application thereof, and belongs to the technical field of chemical medicines. The chalcone compound is a compound as shown in a formula I, or a crystal form thereof, or a salt thereof, or a stereoisomer thereof, or a solvate thereof, or a hydrate thereof, or a prodrug thereof. Wherein R < 1 > to R < 8 > are independently selected from hydrogen, C1-C6 alkyl groups, hydroxyl groups and C1-C6 alkoxy groups respectively. The chalcone compound with remarkable anti-inflammatory activity is obtained by extracting, separating and purifying abelmoschus esculentus seeds. The compound and the derivative thereof can be used as synthesis primers of other compounds and raw materials for new drug development and pharmacological activity research, can be used for preparing anti-inflammatory drugs, can be used as natural products for developing new traditional Chinese medicines, and has a wide medical application prospect.

Description

technical field [0001] The invention belongs to the technical field of chemical medicines, and in particular relates to a chalcone compound and its preparation method and application. Background technique [0002] Ambrette seed is the dried seed of Abelmoschus manihot (Linn.) Medicus., a plant of the Malvaceae family. It has the effect of drying yellow water and repelling insects. Tibetan medicine is used to treat skin diseases, yellow water disease, leprosy and other diseases. Tibetan medical prescription Shiwei frankincense pills and twenty-five flavor donkey blood pills both contain ambrette seeds. "Jingzhu Materia Medica" records: Ambrette seeds are cool and rough in nature, and can treat skin diseases, yellow water diseases and leprosy. "Tara's Materia Medica" records: pungent and bitter, treats yellow water and insect diseases. "Four Medical Codes" records: yellow sunflower cures skin diseases and yellow water diseases. "Medicine Names Collection" records: cure lepr...

Claims

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Application Information

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IPC IPC(8): C07D307/79A61K31/343A61P29/00
CPCY02A50/30
Inventor 苏锦松张艺
Owner CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE