Triazole analogue compound as well as preparation method and application thereof
A technology of analogs and triazoles, which is applied in the field of preparation of triazole analogs, can solve the problems of unstable compounds, high toxicity of raw materials, cumbersome post-processing, etc., and achieve the effects of low toxicity, economical reliability, and simple operation
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Embodiment 1
[0052] Add 5.0g of compound 1, 0.5g of compound 2, 0.46g of DMAP, 0.77g of imidazole, 6ml of DME and stir to dissolve, react at 25°C for 24h, drop the reaction solution into 50ml of water, extract with 100ml of dichloromethane, and concentrate under reduced pressure to obtain dark brown Oily liquid, column chromatography (using 18*160mm glass chromatography column, 300-400 mesh silica gel, petroleum ether and ethyl acetate volume ratio of 6:1 mixed solvent as eluent) was purified for 3 times to obtain a white solid (compound 3) 3.8g, yield 82.9%, purity 98.1%.
Embodiment 2
[0054] Add 5.0g of compound 1, 0.5g of compound 2, 0.46g of DMAP, 0.77g of imidazole, 6ml of MeOH and stir to dissolve, react at 25°C for 24h, drop the reaction liquid into 25ml of water, extract with 100ml of dichloromethane, and concentrate under reduced pressure to obtain dark brown Oily liquid, column chromatography (using 18*160mm glass chromatography column, 300-400 mesh silica gel, petroleum ether and ethyl acetate volume ratio of 6:1 mixed solvent as eluent) was purified for 3 times to obtain a white solid (compound 3) 3.82g, yield 83.1%, purity 98.5%.
Embodiment 3
[0056] Add 5.0g of compound 1, 0.5g of compound 2, 0.46g of DMAP, 0.77g of triethylamine, 6ml of MeOH and stir to dissolve, react at 25°C for 24h, drop the reaction liquid into 25ml of water, extract with 100ml of dichloromethane, and concentrate under reduced pressure to obtain Dark brown oily liquid, purified by column chromatography (using 18*160mm glass chromatography column, 300-400 mesh silica gel, petroleum ether and ethyl acetate with a volume ratio of 6:1 as eluent) 3 times to obtain a white solid (Compound 3) 3.48g, yield 75.8%, purity 98.1%.
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