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Vegetable proteoglycans and uses thereof

A plant-based protein and polysaccharide technology, which is applied in the fields of peptide/protein components, food science, cosmetic preparations, etc., can solve the problems of high manufacturing cost, and achieve the effect of good image, excellent moisturizing effect, and excellent cell proliferation promoting effect

Active Publication Date: 2022-04-12
NOF CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, since animal proteoglycans exist in cartilage in small amounts, there is a problem of high production costs.

Method used

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  • Vegetable proteoglycans and uses thereof
  • Vegetable proteoglycans and uses thereof
  • Vegetable proteoglycans and uses thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0127] [Example 1] Purification based on porous type I strong basic anion exchange resin and strong acidic cation exchange resin treatment

[0128] 50 g of gum arabic (trade name: "Arabiccol SS", Acacia Senegal species, manufactured by Sanei Pharmaceutical Trading Co., Ltd.) was dissolved in ion-exchanged water to prepare 1250 g of a 4.0% (w / w) gum arabic aqueous solution. This aqueous solution of gum arabic, 170 g (251 mL) of porous type I strongly basic anion exchange resin "DIAION PA308" (manufactured by Mitsubishi Chemical Corporation, total exchange capacity = 1.1 meq / mL), and 10 g (12 mL) of strongly acidic cation exchange Resin "DIAIONSK1BH" (manufactured by Mitsubishi Chemical Corporation, gel type, total exchange capacity = 1.9 meq / mL) was placed in a tank, and stirred with a stirrer for 3 hours (liquid temperature = 40±2° C.).

[0129] Next, the ion exchange resin is separated by filtration, and the filtrate is collected. 1M NaOH was added to the filtrate to adjust ...

Embodiment 2

[0132] [Example 2] Purification based on highly porous type I strong basic anion exchange resin and strong acidic cation exchange resin treatment

[0133]3.6 kg of gum arabic (trade name: "Arabiccol SS", Acacia Senegal species, manufactured by Sanei Pharmaceutical Trading Co., Ltd.) was dissolved in ion-exchanged water to prepare 90 kg of a 4.0% (w / w) gum arabic aqueous solution. The aqueous solution of gum arabic, 17.24 kg (25 L) of highly porous type I strongly basic anion exchange resin "DIAION HPA25L" (manufactured by Mitsubishi Chemical Corporation, total exchange capacity = 0.7 meq / mL), and 0.7 kg (0.8 L) Strongly acidic cation exchange resin "DIAION SK1BH" (manufactured by Mitsubishi Chemical Corporation, gel type, total exchange capacity = 1.9 meq / mL) was placed in a tank and stirred with a stirrer for 3 hours (liquid temperature = 20±2°C).

[0134] Next, the ion exchange resin is separated by filtration, and the filtrate is collected. 1M NaOH was added to the filtrat...

Embodiment 3

[0137] [Example 3] Purification based on the treatment of highly porous type I strongly basic anion exchange resin and strongly acidic cation exchange resin

[0138] 50 g of gum arabic (trade name: "Arabiccol SS", Acacia Senegal species, manufactured by Sanei Pharmaceutical Trading Co., Ltd.) was dissolved in ion-exchanged water to prepare 1250 g of a 4.0% (w / w) gum arabic aqueous solution. This aqueous solution of gum arabic, 102 g (150 mL) of highly porous type I strongly basic anion exchange resin "DIAION HPA25L" (manufactured by Mitsubishi Chemical Corporation, total exchange capacity = 0.7 meq / mL), and 5.0 g (6.0 mL) of Acidic cation exchange resin "DIAIONSK1BH" (manufactured by Mitsubishi Chemical Corporation, gel type, total exchange capacity = 1.9 meq / mL) was placed in a tank and stirred with a stirrer for 3 hours (liquid temperature = 40±2°C).

[0139] Next, the ion exchange resin is separated by filtration, and the filtrate is collected. 1M NaOH was added to the fil...

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Abstract

The present invention relates to a plant-based proteoglycan, which is characterized in that the plant-based proteoglycan is obtained from gum arabic obtained from the trunk or branch of a plant of the genus Acacia Sense Wildenow or Acacia Sense Delile, the weight-average molecular weight of the plant-based proteoglycan is 900,000-350,000, and the total aldehyde content of the plant-based proteoglycan is 2.0 [mu] mol equivalent / g or less. According to the present invention, it is possible to provide a vegetable proteoglycan having a physiological activity equivalent to or higher than that of an animal proteoglycan.

Description

technical field [0001] The present invention relates to plant proteoglycans. Specifically, the present invention relates to plant proteoglycans having the same or higher physiological activity as animal proteoglycans. Background technique [0002] In recent years, it has been clarified that glycoproteins have significant physiological activities. As one of the glycoproteins, animal proteoglycans are a general term for compounds composed of multiple glycosaminoglycan sugar chains and a core protein covalently bonded. Widely used as a cosmetic ingredient. As animal proteoglycans, for example, animal proteoglycans derived from salmon nasal cartilage, shark fin cartilage, and squid head cartilage are known. However, since animal proteoglycans exist in cartilage in a trace amount, there is a problem of high production costs. In addition, in the cosmetic market and food market, plant-derived ingredients have a better image than animal-derived ingredients, so animal-derived pro...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08B37/00A61K8/9789A61Q19/00A23L33/105A61K38/02
CPCA23L33/105A61K8/9789A61Q19/00C08B37/0003C08B37/0087C08L5/00A61K2236/00A61K36/48A61K8/645C08B37/0066A61K38/02C08B37/00
Inventor 原真佐夫土田卫
Owner NOF CORP
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