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Blood gas analyzer micro-fluidic chip and matching device and use method thereof

A microfluidic chip and blood gas analyzer technology, applied in the field of medical blood gas biochemical detection equipment, can solve the problems of shortening sample processing time, no microfluidic chip, etc., and achieve good performance and stability

Active Publication Date: 2022-04-15
海南德名声科技有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

A microfluidic chip integrates the basic operating units involved in the fields of biology and chemistry on a small chip; this chip is generally composed of various reservoirs and interconnected microchannel networks, which can greatly shorten sample processing. Time, and through precise control of liquid flow, the maximum utilization efficiency of reagent consumables is realized; at present, in the development trend of blood gas analyzers, microfluidic chips have been widely used in sampling, reagent addition, reaction, separation, detection, etc. New trends in function; for example: the Chinese invention patent application number 201910917654.3 discloses a microfluidic chip and a blood cell detection device. The microfluidic chip is provided with at least a pair of microelectrodes in the sample microchannel, which can When the sample to be tested passes through the microfluidic channel of the sample, a signal change is generated to detect the sample to be tested; however, there are no research reports on the structure and performance parameters of the microfluidic chip.

Method used

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  • Blood gas analyzer micro-fluidic chip and matching device and use method thereof
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  • Blood gas analyzer micro-fluidic chip and matching device and use method thereof

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Experimental program
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Embodiment 1

[0026] The specific implementation manner of the present invention will be described in detail below in conjunction with the accompanying drawings.

[0027] The present invention provides a blood gas analyzer microfluidic chip and its supporting device, including a sampling needle 1, an operating handle 2, a microfluidic chip assembly 3, a peristaltic pump runner 4, a pump tube 5, and an infusion interface 6; wherein , the sampling needle 1 is installed on the internal pipeline of the operating handle 2, and the internal pipeline of the operating handle 2 is connected to the infusion interface at the left end of the microfluidic chip assembly 3 through a connecting tube, and the infusion interface at the right end of the microfluidic chip assembly 3 is connected through the connecting tube and the connecting seat It is connected with the pump tube 5, and the pump tube 5 is closely attached to and wrapped around the peristaltic pump runner 4, and finally the pump tube 5 is conne...

Embodiment 2

[0032] The present invention also provides a method for using the microfluidic chip of a blood gas analyzer and its supporting device, specifically as follows:

[0033] S1: The ambient temperature of the blood gas analyzer microfluidic chip and its supporting devices is kept at room temperature, and the measurement area 3 of the microfluidic chip assembly is heated to 37°C only during calibration and sample measurement;

[0034] S2: Prepare to receive patient samples, start the peristaltic pump runner 4 of the analyzer to rotate counterclockwise, and remove the air in the sampling needle 1;

[0035] S3: Then, the peristaltic pump runner 4 is controlled to rotate clockwise, and the blood sample is transported to the microfluidic chip assembly 3 through the sampling needle 1 for sampling and measurement, and then discharged through the pump tube 5 and the infusion port 6 respectively;

[0036] S4: Take away the sample, wipe the sampling needle 1 clean, perform sample measurement...

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Abstract

The invention belongs to the technical field of medical blood gas biochemical detection equipment, and relates to a blood gas analyzer micro-fluidic chip and a matching device thereof, the blood gas analyzer micro-fluidic chip comprises a sampling needle, an operation handle, a micro-fluidic chip assembly, a peristaltic pump rotating wheel, a pump pipe and a transfusion interface, and a liquid path system for sample transmission, measurement, calibration and flushing of an analyzer can be formed; wherein the micro-fluidic chip assembly consists of a micro-fluidic module shell, a micro-fluidic module liquid circuit board, a micro-fluidic sensor board, a micro-fluidic circuit board and an output signal interface component of the micro-fluidic circuit board; the maximum outer contour lengths and widths of the rear three components are the same, and the three components are respectively and tightly mounted in the micro-fluidic module shell in sequence; electronic signals transmitted from each sensor on the microfluidic sensor plate are transmitted to special analog electronic equipment in the analyzer through an output signal connector; the device can be applied to a blood gas analyzer, so that the device is smaller and lighter, and sample and reagent introduction and transmission and detection steps are minimized and simplified.

Description

technical field [0001] The invention relates to the technical field of medical blood gas biochemical detection equipment, in particular to a microfluidic chip of a blood gas analyzer and its matching device and usage method. Background technique [0002] The blood gas analyzer mainly detects the partial pressure of oxygen (PO) in human arterial blood. 2 ), partial pressure of carbon dioxide (PCO 2 ), hematocrit (Hct), pH (pH), chloride ion (Cl - ), sodium ions (Na + ), potassium ions (K + ), calcium ions (Ca 2+ ), commonly used in intensive care units and emergency laboratories. A microfluidic chip integrates the basic operating units involved in the fields of biology and chemistry on a small chip; this chip is generally composed of various reservoirs and interconnected microchannel networks, which can greatly shorten sample processing. Time, and through precise control of liquid flow, the maximum utilization efficiency of reagent consumables is realized; at present, i...

Claims

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Application Information

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IPC IPC(8): G01N27/327G01N27/26G01N27/06G01N27/00B01L3/00
Inventor 孙明伟肖锦峰孙晓辰张玉亮邓振龙张少文
Owner 海南德名声科技有限责任公司
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